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Consolidated Statements of Cash Flows (USD $) | 12 Months Ended
--- | ---
Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Cash flows from operating activities: |  |  |  |  |
Net loss | $ (26,439,159) |  | $ (28,491,153) |  | $ (21,328,538)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |
Depreciation and amortization | 1,058,725 |  | 991,721 |  | 1,207,911
Amortization of debt discount and issuance costs | 288,951 |  |  |  |
Stock-based compensation for employees and external services | 2,608,670 |  | 2,878,134 |  | 3,260,937
Loss (gain) on disposal of fixed assets | (38,854) |  | 20,883 |  | 32,145
Write-down of fixed assets |  |  | 27,500 |  |
Impairment of intangible asset |  |  |  |  | 654,961
Gain on sale of marketable securities |  |  |  |  | (83,750)
Change in fair value of warrant liability | (3,253,253) |  | 5,944,571 |  | (6,612,092)
Changes in operating assets and liabilities: |  |  |  |  |
Other receivables | (298,734) |  | 39,825 |  | (78,503)
Trade receivables | 3,606 |  | (50,451) |  | 67,974
Prepaid and other current assets | 801,611 |  | 22,232 |  | 495,662
Other assets | 493,584 |  | 89,790 |  | 76,187
Accounts payable and accrued expenses | 2,143,917 |  | (409,333) |  | 130,766
Accrued wind-down expenses | (1,102,762) |  | (1,032,024) |  | (1,165,585)
Deferred revenue | (24,270) |  | 13,389 |  | (18,903)
Deferred rent | 435,967 |  | 85,572 |  | 1,302,543
Net cash used in operating activities | (23,322,001) |  | (19,869,344) |  | (22,058,283)
Cash flows from investing activities: |  |  |  |  |
Purchases of marketable debt securities | (687,798) |  | (16,380,748) |  | (10,188,285)
Sales or maturities of marketable debt securities | 14,430,000 |  | 5,762,000 |  | 6,905,000
Proceeds from sales of marketable equity securities |  |  |  |  | 158,206
Purchases of property, plant and equipment | (4,680,796) |  | (73,083) |  | (296,933)
Proceeds from sale of property, plant and equipment | 38,500 |  |  |  |
Acquisition of other assets | (64,000) |  |  |  |
Net cash provided by (used) in investing activities | 9,035,906 |  | (10,691,831) |  | (3,422,012)
Cash flows from financing activities: |  |  |  |  |
Proceeds from issuance of common stock, net | 23,491,597 |  | 19,747,550 |  | 19,774,820
Proceeds from the exercise of warrants | 530,097 |  | 6,256,438 |  |
Proceeds from the exercise of stock options | 3,452 |  | 3,629 |  | 2,386
Proceeds from loan payable, net of issuance costs | 13,558,358 |  |  |  |
Payments related to net share issuance of stock based awards | (342,366) |  | (59,090) |  | (403,625)
Repayments of capital lease obligations | (12,396) |  | (20,167) |  | (67,847)
Repayments of debt obligations | (826,465) |  | (191,250) |  | (176,250)
Net cash provided by financing activities | 36,402,277 |  | 25,737,110 |  | 19,129,484
Increase (decrease) in cash and cash equivalents | 22,116,182 |  | (4,824,065) |  | (6,350,811)
Cash and cash equivalents at beginning of year | 8,471,275 |  | 13,311,261 |  | 19,707,821
Effects of foreign currency rate changes on cash | (2,033) |  | (15,921) |  | (45,749)
Cash and cash equivalents at end of the year | 30,585,424 |  | 8,471,275 |  | 13,311,261
Supplemental disclosure of cash flow information: |  |  |  |  |
Interest paid | 427,040 |  | 50,193 |  | 71,363
Supplemental schedule of non-cash investing and financing activities: |  |  |  |  |
Stock issued for an option agreement |  |  | 50,000 | [1] |
Equipment acquired under a capital lease | 43,600 | [2] | 21,721 | [2] |
Equity Financing Agreement [Member] |  |  |  |  |
Supplemental schedule of non-cash investing and financing activities: |  |  |  |  |
Fair value of shares issued as consideration | 600,006 | [3] |  |  |
Acquired Patent Portfolio [Member] |  |  |  |  |
Supplemental schedule of non-cash investing and financing activities: |  |  |  |  |
Fair value of shares issued as consideration | $ 200,000 | [4] |  |  |
[1] | In September 2012, we issued 24,753 shares of restricted common stock under the terms of an agreement with a developer of biological materials in return for certain product rights including an exclusive right of first offer to commercialize the developer's products as may be developed on or before April 18, 2017.
[2] | Represents the present value of future minimum capital lease payments for equipment leased.
[3] | In June 2013, we entered into an agreement with an institutional investor, under which we have the right to sell up to $30.0 million of common stock to the institutional investor. In consideration for entering into the agreement, we issued 329,131 shares of our common stock to the institutional investor. We will not receive any cash proceeds from the issuance of these 329,131 shares. All shares sold or to be sold under this agreement are offered under our shelf registration statement previously filed with, and declared effective by, the SEC. In October 2013, we terminated the agreement without any cost or penalty.
[4] | In October, 2013, we acquired from NeuroSpheres a patent portfolio we licensed on an exclusive worldwide basis, including the six patents that are the subject of our patent infringement litigation against Neuralstem. As consideration for the patents, we issued 139,548 shares of unregistered common stock with a fair value of $200,000 to NeuroSpheres. In connection with the patent acquisition, all preexisting agreements were terminated. The acquisition relieves us from further milestone and royalty payments to NeuroSpheres.

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- Definition Amount of cash inflow (outflow) from operating activities, including discontinued operations. Operating activity cash flows include transactions, adjustments, and changes in value not defined as investing or financing activities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 24 -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3521-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 25 -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3536-108585 + Details
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- Definition The portion of profit or loss for the period, net of income taxes, which is attributable to the parent. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 04 -Paragraph 20 -Article 9 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Other Comprehensive Income -URI http://asc.fasb.org/extlink&oid=6519514 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Net Income -URI http://asc.fasb.org/extlink&oid=6518256 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257 Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 225 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-04.19) -URI http://asc.fasb.org/extlink&oid=6879464&loc=d3e573970-122913 Reference 7: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.18) -URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688 Reference 8: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 225 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-04.22) -URI http://asc.fasb.org/extlink&oid=6879464&loc=d3e573970-122913 Reference 9: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=28358780&loc=d3e565-108580 Reference 10: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 19 -Article 5 + Details
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- Definition The cash outflow for cost incurred directly with the issuance of an equity security. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3291-108585 + Details
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- Definition Cash outflow for purchase of trading, available-for-sale securities and held-to-maturity securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=6871852&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3213-108585 + Details
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- Definition The cash outflow for acquisition of or capital improvements on other tangible or intangible assets not otherwise defined in the taxonomy. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3255-108585 + Details
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- Definition The cash inflow from a borrowing supported by a written promise to pay an obligation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3255-108585 + Details
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