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Income Taxes - Components of Deferred Tax Assets and Liabilities (Detail) (USD $) | Dec. 31, 2013 | Dec. 31, 2012
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Deferred tax assets: |  |
Capitalized research and development costs | $ 59,426,000 | $ 53,824,000
Net operating losses | 56,906,000 | 53,687,000
Research and development credits | 8,931,000 | 7,777,000
Accrued wind down cost |  | 292,000
Stock-based compensation | 1,063,000 | 853,000
Capital loss carryover | 541,000 | 544,000
Fixed assets | 452,000 | 430,000
Other | 1,289,000 | 1,002,000
Gross deferred tax assets | 128,608,000 | 118,409,000
Valuation allowance | (128,315,000) | (118,045,000)
Total deferred tax assets | 293,000 | 364,000
Deferred tax liability: |  |
Intangible assets | (293,000) | (364,000)
Total deferred tax liability | (293,000) | (364,000)
Net deferred tax assets | $ 0 |

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