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Consolidated Statements of Operations (USD $) | 12 Months Ended
--- | ---
Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Revenue: |  |  |
Revenue from licensing agreements, grants and other | $ 205,302 | $ 511,558 | $ 557,880
Revenue from product sales | 997,968 | 856,397 | 662,790
Total revenue | 1,203,270 | 1,367,955 | 1,220,670
Cost of product sales | 316,628 | 263,188 | 214,811
Gross profit | 886,642 | 1,104,767 | 1,005,859
Operating expenses: |  |  |
Research and development | 20,533,713 | 15,846,829 | 19,937,764
Selling, general and administrative | 8,896,537 | 7,447,235 | 8,202,375
Wind-down expenses | 61,837 | 356,379 | 287,122
Impairment of intangible asset |  |  | 654,961
Total operating expenses | 29,492,087 | 23,650,443 | 29,082,222
Operating loss | (28,605,445) | (22,545,676) | (28,076,363)
Other income (expense): |  |  |
Realized gain on sale of marketable securities |  |  | 83,750
Change in fair value of warrant liability | 3,253,253 | (5,944,571) | 6,612,092
Interest income | 11,318 | 15,594 | 13,942
Interest expense | (1,166,782) | (50,193) | (71,363)
Other income | 68,497 | 33,693 | 109,404
Total other income (expense), net | 2,166,286 | (5,945,477) | 6,747,825
Net loss | $ (26,439,159) | $ (28,491,153) | $ (21,328,538)
Basic and diluted net loss per share | $ (0.61) | $ (0.99) | $ (1.50)
Shares used to compute basic and diluted loss per share | 43,422,001 | 28,824,417 | 14,187,885

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