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Summary of Significant Accounting Policies - Additional Information (Detail) (USD $) | 1 Months Ended | 12 Months Ended |  |  | 12 Months Ended |  | 12 Months Ended | 1 Months Ended | 12 Months Ended |  |  | 1 Months Ended | 12 Months Ended |  |  | 1 Months Ended |  |  | 1 Months Ended
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Oct. 31, 2013 | Dec. 31, 2013 Segment | Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2013 Outstanding warrants [Member] | Oct. 31, 2013 Common Stock [Member] | Dec. 31, 2013 Marketable debt securities, current [Member] Minimum [Member] | Dec. 31, 2013 Marketable securities, non-current [Member] Maximum [Member] | Dec. 31, 2013 Indefinite-lived intangible acquired [Member] | Dec. 31, 2013 December 2011 Financing [Member] Common Stock [Member] | Dec. 31, 2012 December 2011 Financing [Member] Common Stock [Member] | Dec. 31, 2011 December 2011 Financing [Member] Series A Warrants [Member] | Dec. 31, 2012 December 2011 Financing [Member] Series A Warrants [Member] | Dec. 31, 2013 December 2011 Financing [Member] Series A Warrants [Member] | Dec. 31, 2011 December 2011 Financing [Member] Series A Warrants [Member] Common Stock [Member] | Dec. 31, 2011 December 2011 Financing [Member] Series B Warrants [Member] | Dec. 31, 2012 December 2011 Financing [Member] Series B Warrants [Member] | Dec. 31, 2013 November 2008 Financing [Member] | Dec. 31, 2013 November 2008 Financing [Member] Outstanding warrants [Member] | Nov. 30, 2008 November 2008 Financing [Member] Common Stock [Member] | Nov. 30, 2008 November 2008 Financing [Member] Outstanding warrants [Member] | Dec. 31, 2013 November 2009 Financing [Member] | Dec. 31, 2013 November 2009 Financing [Member] Outstanding warrants [Member] | Nov. 30, 2009 November 2009 Financing [Member] Common Stock [Member] | Nov. 30, 2009 November 2009 Financing [Member] Outstanding warrants [Member]
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of segments |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accumulated deficit |  | $ (387,530,334) | $ (361,091,175) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maturity period for money market and highly liquid investments |  | 90 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Investments with maturities |  |  |  |  |  |  | 365 days or less | Greater than 365 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Goodwill |  | 2,139,294 | 1,983,426 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Impairment of goodwill |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Intangible assets with finite useful lives |  | 1,836,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Intangible asset impaired and wrote off carrying value of the asset |  |  |  | 654,961 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Value of patent |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of certain lab equipment |  | 0 | 28,000 | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant component |  |  |  |  |  | 0.5 |  |  |  | 1 |  |  |  | 1 |  |  |  |  |  | 0.75 |  |  |  | 0.40 |
Number of securities callable by warrants |  |  |  |  |  |  |  |  |  |  |  | 8,000,000 |  |  |  | 8,000,000 |  |  |  | 1,034,483 |  |  |  | 400,000 |
Exercise price of warrants | 1.80 |  |  |  |  |  |  |  |  |  |  |  |  |  | 1.40 | 1.25 |  | 23.00 |  | 23.00 |  | 15.00 |  | 15.00 |
Term of warrant |  |  |  |  |  |  |  |  |  |  |  | 5 years |  |  |  | 90 days |  |  |  |  | 5 years |  |  |  | 5 years
Common stock per unit |  |  | $ 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants issued per unit |  |  | $ 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants exercised |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,700,000 |  |  |  |  |  |  |  |
Number of shares issued upon Series B warrants exercise | 12,845,500 |  |  |  |  |  |  |  |  | 384,534 | 2,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants issued upon Series B warrants exercise |  |  |  |  |  |  |  |  |  |  |  |  | 2,700,000 |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants expired |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,300,000 |  |  |  |  |  |  |  |
Fair value of derivative liability |  |  |  |  | 5,541,809 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net deferred tax liability |  | $ 293,000 | $ 364,000 |  |  |  |  |  | $ 118,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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