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Consolidated Statements of Operations (USD $)
 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Revenue:      
Revenue from licensing agreements, grants and other $ 205,302 $ 511,558 $ 557,880
Revenue from product sales 997,968 856,397 662,790
Total revenue 1,203,270 1,367,955 1,220,670
Cost of product sales 316,628 263,188 214,811
Gross profit 886,642 1,104,767 1,005,859
Operating expenses:      
Research and development 20,533,713 15,846,829 19,937,764
Selling, general and administrative 8,896,537 7,447,235 8,202,375
Wind-down expenses 61,837 356,379 287,122
Impairment of intangible asset     654,961
Total operating expenses 29,492,087 23,650,443 29,082,222
Operating loss (28,605,445) (22,545,676) (28,076,363)
Other income (expense):      
Realized gain on sale of marketable securities     83,750
Change in fair value of warrant liability 3,253,253 (5,944,571) 6,612,092
Interest income 11,318 15,594 13,942
Interest expense (1,166,782) (50,193) (71,363)
Other income 68,497 33,693 109,404
Total other income (expense), net 2,166,286 (5,945,477) 6,747,825
Net loss $ (26,439,159) $ (28,491,153) $ (21,328,538)
Basic and diluted net loss per share $ (0.61) $ (0.99) $ (1.50)
Shares used to compute basic and diluted loss per share 43,422,001 28,824,417 14,187,885