Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2013

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Our stock-based compensation expense for the last three fiscal years was as follows:


	2013		2012		2011
Research and development expense	$	1,219,308	$	1,280,298	$	1,680,431
General and administrative expense		1,389,362		1,597,836		1,580,506

Total stock-based compensation expense and effect on net loss	$	2,608,670	$	2,878,134	$	3,260,937

Schedule of Fair Value Option Award, Assumptions

The weighted-average assumptions used for the last three fiscal years are as follows:


	2013			2012			2011
Expected term (years)(1)		5.1			6.4			7.4
Risk-free interest rate(2)		1.2	%		1.4	%		2.7	%
Expected volatility(3)		89.3	%		78.4	%		79.7	%
Expected dividend yield(4)		0	%		0	%		0	%

(1)

The expected term represents the period during which our stock-based awards are expected to be outstanding. We estimated this amount based on historical experience of similar awards, giving consideration to the contractual terms of the awards, vesting requirements, and expectation of future employee behavior, including post-vesting terminations.

(2)	The risk-free interest rate is based on U.S. Treasury debt securities with maturities close to the expected term of the option as of the date of grant.

(3)	Expected volatility is based on historical volatility over the most recent historical period equal to the length of the expected term of the option as of the date of grant.

(4)	We have neither declared nor paid dividends on any share of common stock and we do not expect to do so in the foreseeable future.

Stock Option Activity

A summary of our stock option activity and related information for the last three fiscal years is as follows:


	Outstanding Options
	Number of Shares			Weighted- Average Exercise Price		Weighted-Average Remaining Contractual Term		Aggregate Intrinsic Value(1)
Balance at December 31, 2010		1,098,241		$	20.20		6.1	$	398,219
Granted		3,750		$	7.30
Exercised		(1,692	)	$	1.41			$	11,293
Cancelled (forfeited and expired)		(224,801	)	$	20.22

Balance at December 31, 2011		875,498		$	20.13		5.5	$	—
Granted		—
Exercised		(3,629	)	$	1.00			$	4,319
Cancelled (forfeited and expired)		(424,510	)	$	20.86

Balance at December 31, 2012		447,359		$	19.59		5.1	$	2,175
Granted		—
Exercised		(3,452	)	$	1.00			$	2,214
Cancelled (forfeited and expired)		(15,649	)	$	13.06

Balance at December 31, 2013		428,258		$	19.97		4.3	$	—

Exercisable at December 31, 2013		409,792		$	20.42		4.2	$	—

Vested and expected to vest(2)		426,027		$	20.02		4.3	$	—

(1)

Aggregate intrinsic value represents the value of the closing price per share of our common stock on the last trading day of the fiscal period in excess of the exercise price multiplied by the number of options outstanding or exercisable, except for the “Exercised” line, which uses the closing price on the date exercised.

(2)	Number of shares includes options vested and those expected to vest net of estimated forfeitures.

Summary of Changes in Unvested Options

The following is a summary of changes in unvested options:


Unvested Options	Number of Options			Weighted Average Grant Date Fair Value
Unvested options at December 31, 2012		64,503		$	8.67
Granted		—			—
Vested		(45,564	)	$	8.91
Cancelled		(473	)	$	7.82

Unvested options at December 31, 2013		18,466		$	8.11

Weighted Average Exercise Price and Remaining Term Information about Significant Option Groups Outstanding

The following table presents weighted average exercise price and remaining term information about significant option groups outstanding at December 31, 2013:


Options Outstanding at December 31, 2013
Range of Exercise Prices	Number Outstanding		Weighted Average Remaining Term (Yrs.)		Weighted Average Exercise Price		Aggregate Intrinsic Value at December 31, 2013
Less than $10.00		4,050		7.3	$	7.42	$	—
$10.00 - $19.99		250,949		5.3	$	12.65		—
$20.00 - $29.99		117,459		3.1	$	23.22		—
$30.00 - $39.99		19,800		1.9	$	36.46		—
$40.00 - $49.99		5,500		1.7	$	46.51		—
$50.00 - $59.99		30,500		1.7	$	53.94		—

		428,258		4.3	$	19.97	$	—


Vested Options Outstanding at December 31, 2013
Range of Exercise Prices	Number Outstanding		Weighted Average Exercise Price
Less than $10.00		2,677	$	7.45
$10.00 - $19.99		233,856	$	12.81
$20.00 - $29.99		117,459	$	23.22
$30.00 - $39.99		19,800	$	36.46
$40.00 - $49.99		5,500	$	46.51
$50.00 - $59.99		30,500	$	53.94

		409,792	$	20.42

Summary of Restricted Stock Unit Activity

A summary of our restricted stock unit activity for the year ended December 31, 2013 is as follows:


	Number of RSUs			Weighted Average Grant Date Fair Value
Outstanding at January 1, 2013		1,534,200		$	2.10
Granted(1)		2,421,965		$	1.80
Vested and exercised		(565,883	)	$	3.37
Cancelled		(64,000	)	$	1.61

Outstanding at December 31, 2013		3,326,282		$	1.68

(1)

11,765 of these restricted stock units vested on the date of grant. 55,000 of these restricted stock units vest and convert into shares of our common stock after one year from the date of grant. 2,355,200 of these restricted stock units vest and convert into shares of our common stock over a four year period from the date of grant: one-fourth of the award will vest on each grant date anniversary following the grant.

Summary of Changes in Outstanding SARs

The following is a summary of the changes in our outstanding SARs for the last three fiscal years:


	2013				2012					2011
	Number		Weighted Average Exercise Price		Number			Weighted Average Exercise Price		Number			Weighted Average Exercise Price
Outstanding at January 1,		110,593	$	20.00		115,187		$	20.00		135,409		$	20.00
Granted		—		—		—			—		—			—
Exercised		—		—		—			—		—			—
Forfeited		—				(4,594	)				(20,222	)

Outstanding at December 31,		110,593	$	20.00		110,593		$	20.00		115,187		$	20.00

Exercisable at December 31,		110,593	$	20.00		110,593		$	20.00		115,187		$	20.00