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Summary of Significant Accounting Policies - Additional Information (Detail) (USD $)
 1 Months Ended 12 Months Ended 12 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended 1 Months Ended 1 Months Ended
Oct. 31, 2013
Dec. 31, 2013
Segment
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2013
Outstanding warrants [Member]
Oct. 31, 2013
Common Stock [Member]
Dec. 31, 2013
Marketable debt securities, current [Member]
Minimum [Member]
Dec. 31, 2013
Marketable securities, non-current [Member]
Maximum [Member]
Dec. 31, 2013
Indefinite-lived intangible acquired [Member]
Dec. 31, 2013
December 2011 Financing [Member]
Common Stock [Member]
Dec. 31, 2012
December 2011 Financing [Member]
Common Stock [Member]
Dec. 31, 2011
December 2011 Financing [Member]
Series A Warrants [Member]
Dec. 31, 2012
December 2011 Financing [Member]
Series A Warrants [Member]
Dec. 31, 2013
December 2011 Financing [Member]
Series A Warrants [Member]
Dec. 31, 2011
December 2011 Financing [Member]
Series A Warrants [Member]
Common Stock [Member]
Dec. 31, 2011
December 2011 Financing [Member]
Series B Warrants [Member]
Dec. 31, 2012
December 2011 Financing [Member]
Series B Warrants [Member]
Dec. 31, 2013
November 2008 Financing [Member]
Dec. 31, 2013
November 2008 Financing [Member]
Outstanding warrants [Member]
Nov. 30, 2008
November 2008 Financing [Member]
Common Stock [Member]
Nov. 30, 2008
November 2008 Financing [Member]
Outstanding warrants [Member]
Dec. 31, 2013
November 2009 Financing [Member]
Dec. 31, 2013
November 2009 Financing [Member]
Outstanding warrants [Member]
Nov. 30, 2009
November 2009 Financing [Member]
Common Stock [Member]
Nov. 30, 2009
November 2009 Financing [Member]
Outstanding warrants [Member]
Class of Warrant or Right [Line Items]                                                  
Number of segments   1                                              
Accumulated deficit   $ (387,530,334) $ (361,091,175)                                            
Maturity period for money market and highly liquid investments   90 days                                              
Investments with maturities             365 days or less Greater than 365 days                                  
Goodwill   2,139,294 1,983,426                                            
Impairment of goodwill   0                                              
Intangible assets with finite useful lives   1,836,000                                              
Intangible asset impaired and wrote off carrying value of the asset       654,961                                          
Value of patent   0                                              
Fair value of certain lab equipment   0 28,000 0                                          
Warrant component           0.5       1       1           0.75       0.40  
Number of securities callable by warrants                       8,000,000       8,000,000       1,034,483       400,000  
Exercise price of warrants 1.80                           1.40 1.25   23.00   23.00   15.00   15.00  
Term of warrant                       5 years       90 days         5 years       5 years
Common stock per unit     $ 1                                            
Warrants issued per unit     $ 1                                            
Number of warrants exercised                                 2,700,000                
Number of shares issued upon Series B warrants exercise 12,845,500                 384,534 2,700,000                            
Number of warrants issued upon Series B warrants exercise                         2,700,000                        
Number of warrants expired                                 5,300,000                
Fair value of derivative liability         5,541,809                                          
Net deferred tax liability   $ 293,000 $ 364,000           $ 118,000