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Consolidated Statement of Stockholders' Equity (USD $)
Total
Common Stock [Member]
Additional Paid-in Capital [Member]
Accumulated Deficit [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Beginning Balance at Dec. 31, 2010 $ 15,480,629 $ 127,313 $ 326,505,080 $ (311,271,486) $ 119,722
Beginning Balance, Shares at Dec. 31, 2010   12,731,287      
Net loss (21,328,538)     (21,328,536)  
Unrealized gain on foreign currency translation 40,032       40,032
Change in unrealized loss on securities available-for-sale (119,041)       (119,041)
Issuance of common stock and warrants, net of issuance cost of $1,522,083, $900,992 and $2,051,699 in 2011,2012 and 2013 respectively 13,792,340 95,251 13,697,089    
Issuance of common stock and warrants, net of issuance cost of $1,522,083, $900,992 and $2,051,699 in 2011, 2012 and 2013 respectively, shares   9,525,116      
Common stock issued pursuant to employee benefit plan 164,896 352 164,544    
Common stock issued pursuant to employee benefit plan, shares   35,164      
Compensation expense from grant of options and restricted stock units (fair value) 3,096,043 326 3,095,717    
Compensation expense from grant of options and restricted stock units (fair value), shares   32,631      
Exercise of employee and director stock options 2,386 17 2,369    
Exercise of employee and director stock options, shares 1,692 1,692      
Exercise and net settlement of restricted stock units (403,625) 1,021 (404,646)    
Exercise and net settlement of restricted stock units, shares   102,065      
Ending Balance at Dec. 31, 2011 10,725,124 224,280 343,060,153 (332,600,022) 40,713
Ending Balance, Shares at Dec. 31, 2011   22,427,955      
Net loss (28,491,153)     (28,491,153)  
Unrealized gain on foreign currency translation 151,125       151,125
Change in unrealized loss on securities available-for-sale 1,339       1,339
Issuance of common stock and warrants, net of issuance cost of $1,522,083, $900,992 and $2,051,699 in 2011,2012 and 2013 respectively 28,725,507 145,460 28,580,047    
Issuance of common stock and warrants, net of issuance cost of $1,522,083, $900,992 and $2,051,699 in 2011, 2012 and 2013 respectively, shares   14,546,042      
Common stock issued for external services 175,235 1,021 174,214    
Common stock issued for external services, shares   102,058      
Common stock issued pursuant to employee benefit plan 97,017 1,299 95,718    
Common stock issued pursuant to employee benefit plan, shares   129,893      
Compensation expense from grant of options and restricted stock units (fair value) 2,655,884 1,825 2,654,059    
Compensation expense from grant of options and restricted stock units (fair value), shares   182,502      
Exercise of employee and director stock options 3,629 36 3,593    
Exercise of employee and director stock options, shares 3,629 3,629      
Exercise and net settlement of restricted stock units (59,090) 1,142 (60,232)    
Exercise and net settlement of restricted stock units, shares   114,226      
Ending Balance at Dec. 31, 2012 13,984,617 375,063 374,507,552 (361,091,175) 193,177
Ending Balance, Shares at Dec. 31, 2012   37,506,305      
Net loss (26,439,159)     (26,439,159)  
Unrealized gain on foreign currency translation 57,568       57,568
Change in unrealized loss on securities available-for-sale 1,356       1,356
Issuance of common stock and warrants, net of issuance cost of $1,522,083, $900,992 and $2,051,699 in 2011,2012 and 2013 respectively 24,879,573 169,385 24,710,188    
Issuance of common stock and warrants, net of issuance cost of $1,522,083, $900,992 and $2,051,699 in 2011, 2012 and 2013 respectively, shares   16,938,575      
Common stock issued for external services 154,111 1,049 153,062    
Common stock issued for external services, shares   104,911      
Common stock issued pursuant to employee benefit plan 132,071 829 131,242    
Common stock issued pursuant to employee benefit plan, shares   82,863      
Compensation expense from grant of options and restricted stock units (fair value) 2,322,489   2,322,489    
Compensation expense from grant of options and restricted stock units (fair value), shares           
Exercise of employee and director stock options 3,452 35 3,417    
Exercise of employee and director stock options, shares 3,452 3,452      
Exercise and net settlement of restricted stock units (342,366) 3,627 (345,993)    
Exercise and net settlement of restricted stock units, shares   362,657      
Common stock issued as consideration in the acquisition of a patent portfolio 200,000 1,395 198,605    
Common stock issued as consideration in the acquisition of a patent portfolio, shares   139,548      
Ending Balance at Dec. 31, 2013 $ 14,953,712 $ 551,383 $ 401,680,562 $ (387,530,334) $ 252,101
Ending Balance, Shares at Dec. 31, 2013   55,138,311