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Stock-Based Compensation (Tables) | 3 Months Ended
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Mar. 31, 2014
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] |
Stock-Based Compensation Expense | Our stock-based compensation expense for the three months ended March 31 was as follows:
|  | Three months ended March 31, |
|  | 2014 |  |  | 2013 |
Research and development expense |  | $ | 186,293 |  |  | $ | 343,711 |
Selling, general and administrative expense |  |  | 334,813 |  |  |  | 342,871 |
Total stock-based compensation |  | $ | 521,106 |  |  | $ | 686,582 |
Effect on basic and diluted net loss per share |  | $ | (0.01 | ) |  | $ | (0.02 | )
Stock Option Activity | A summary of our stock option activity for the three months ended March 31, 2014 is as follows:
|  | Number of options |  |  | Weighted-average exercise price ($) per share |
Outstanding options at December 31, 2013 |  |  | 428,258 |  |  |  | 19.97 |
Granted |  |  | — |  |  |  | — |
Exercised |  |  | — |  |  |  | — |
Cancelled |  |  | (46,407 | ) |  |  | 35.81 |
Outstanding options at March 31, 2014 |  |  | 381,851 |  |  |  | 18.05 |
Summary of Changes in Unvested Options | A summary of changes in unvested options for the three months ended March 31, 2014 is as follows:
|  | Number of options |  |  | Weighted-average exercise price ($) per share |  |  | Weighted-average grant date fair value ($) per option |
Unvested options at December 31, 2013 |  |  | 18,466 |  |  |  | 10.17 |  |  |  | 8.11 |
Granted |  |  | — |  |  |  | — |  |  |  | — |
Vested |  |  | (9,283 | ) |  |  | 10.45 |  |  |  | 8.33 |
Cancelled |  |  | (1,591 | ) |  |  | 8.13 |  |  |  | 6.12 |
Unvested options at March 31, 2014 |  |  | 7,592 |  |  |  | 10.27 |  |  |  | 8.26 |
Summary of Changes in Unvested Restricted Stock Units | A summary of changes in our restricted stock units for the three months ended March 31, 2014 is as follows:
|  | Number of RSUs |  |  | Weighted Average Grant Date Fair Value ($) |
Outstanding at December 31, 2013 |  |  | 3,326,282 |  |  |  | 1.68 |
Granted(1) |  |  | 594,874 |  |  |  | 1.34 |
Vested and exercised |  |  | (376,216 | ) |  |  | 1.10 |
Cancelled |  |  | (400,000 | ) |  |  | 1.84 |
Outstanding at March 31, 2014 |  |  | 3,144,940 |  |  |  | 1.66 |
(1) | 218,874 of these restricted stock units vest and convert into shares of our common stock after one year from the date of grant. 376,000 of these restricted stock units will vest and convert into shares of our common stock over a four year period from the date of grant; one-fourth of the award will vest on each grant date anniversary following the grant.

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the changes in outstanding nonvested restricted stock units. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the changes in outstanding nonvested shares. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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