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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2015
Income Tax Disclosure [Abstract] |
Loss before Income Tax Attributable to Geographic Location | Loss before income taxes is attributed to the following geographic locations for the years ended December 31,
|  | 2015 |  |  | 2014 |
United States |  | $ | 36,065,000 |  |  | $ | 30,215,000 |
Foreign |  |  | 350,000 |  |  |  | 2,526,000 |
Total loss before income taxes |  | $ | 36,415,000 |  |  | $ | 32,741,000 |
Components of Deferred Tax Assets and Liabilities | Significant components of our deferred tax assets and liabilities at December 31 are as follows:
|  | 2015 |  |  | 2014 |
Deferred tax assets: |  |  |  |  |  |  |  |
Capitalized research and development costs |  | $ | 75,409,000 |  |  | $ | 66,212,000 |
Net operating losses |  |  | 59,319,000 |  |  |  | 57,261,000 |
Research and development credits |  |  | 10,581,000 |  |  |  | 9,798,000 |
Stock-based compensation |  |  | 1,925,000 |  |  |  | 1,124,000 |
Capital loss carryover |  |  | 264,000 |  |  |  | 254,000 |
Fixed assets |  |  | (107,000 | ) |  |  | 393,000 |
Other |  |  | 4,707,000 |  |  |  | 3,930,000 |
|  |  | 152,098,000 |  |  |  | 138,972,000 |
Valuation allowance |  |  | (152,098,000 | ) |  |  | (138,972,000 | )
Total deferred tax assets |  | $ | — |  |  | $ | — |
Reconciliation of Federal Income Tax Rate | The effective tax rate as a percentage of income before income taxes differs from the statutory federal income tax rate (when applied to income before income taxes) for the years ended December 31 as follows:
|  | 2015 |  |  | 2014 |  |  | 2013 |
Statutory federal income tax (benefit) rate |  |  | (34 | )% |  |  | (34 | )% |  |  | (34 | )%
State income tax (benefit) rate |  |  | (0.6 | ) |  |  | — |  |  |  | — |
Increase resulting from: |  |  |  |  |  |  |  |  |  |  |  |
Expenses not deductible for taxes |  |  | 0.1 |  |  |  | 0.8 |  |  |  | 0.5 |
Increase in valuation allowance |  |  | 36.0 |  |  |  | 32.6 |  |  |  | 38.8 |
Change in state deferred tax rate |  |  | (2.2 | ) |  |  | 0.0 |  |  |  | 1.1 |
Change in foreign deferred tax rate |  |  | 0.3 |  |  |  | 2.8 |  |  |  | 0.9 |
Expiration of tax attributes |  |  | 1.2 |  |  |  | 1.7 |  |  |  | 0.5 |
Prior year true up |  |  | 2.5 |  |  |  | 1.1 |  |  |  | (0.7 | )
Tax credits |  |  | (2.5 | ) |  |  | (2.4 | ) |  |  | (3.0 | )
Warrant valuation |  |  | (0.9 | ) |  |  | (2.5 | ) |  |  | (4.1 | )
Effective tax (benefit) rate |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %

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