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Income Taxes - Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) | Dec. 31, 2015 | Dec. 31, 2014
--- | --- | ---
Deferred tax assets: |  |
Capitalized research and development costs | $ 75,409,000 | $ 66,212,000
Net operating losses | 59,319,000 | 57,261,000
Research and development credits | 10,581,000 | 9,798,000
Stock-based compensation | 1,925,000 | 1,124,000
Capital loss carryover | 264,000 | 254,000
Fixed assets | (107,000) | 393,000
Other | 4,707,000 | 3,930,000
Gross deferred tax assets | 152,098,000 | 138,972,000
Valuation allowance | (152,098,000) | (138,972,000)
Total deferred tax assets | $ 0 | $ 0

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