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Consolidated Statements of Operations - USD ($)
 12 Months Ended
Dec. 31, 2015
Nov. 30, 2014
Dec. 31, 2013
Revenue:      
Revenue from licensing agreements, grants and other $ 116,887 $ 1,012,391 $ 172,297
Operating expenses:      
Research and development 27,110,909 21,503,085 19,368,888
General and administrative 9,334,174 10,419,620 8,834,271
Wind-down expenses 392,230   61,837
Total operating expenses 36,837,313 31,922,705 28,264,996
Operating loss (36,720,426) (30,910,314) (28,092,699)
Other income (expense):      
Change in fair value of warrant liability 913,587 2,422,451 3,253,253
Impairment of goodwill   (1,910,062)  
Impairment of other intangible assets (239,241) (530,100)  
Interest income 7,544 8,532 11,318
Interest expense (506,319) (1,295,404) (1,166,782)
Other income (expense), net 129,829 (45,766) 8,218
Total other income (expense), net 305,400 (1,350,349) 2,106,007
Net loss from continuing operations (36,415,026) (32,260,663) (25,986,692)
Discontinued operations:      
Loss from discontinued operations   (369,357) (452,467)
Net loss on disposal of assets   (111,254)  
Net loss from discontinued operations   (480,611) (452,467)
Net loss $ (36,415,026) $ (32,741,274) $ (26,439,159)
Basic and diluted net loss per share:      
Basic and diluted net loss per share from continuing operations $ (0.38) $ (0.52) $ (0.60)
Basic and diluted net loss per share from discontinued operations   (0.01) (0.01)
Basic and diluted net loss per share $ (0.38) $ (0.53) $ (0.61)
Shares used to compute basic and diluted loss per share 95,807,377 61,612,957 43,422,001