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Stock-Based Compensation - Stock-Based Compensation Expense (Detail) - USD ($) | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2016 | Jun. 30, 2015 | Jun. 30, 2016 | Jun. 30, 2015
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Total stock-based compensation | $ (920,112) | $ 1,351,574 | $ 932,314 | $ 2,660,468
Effect on basic and diluted net loss per share | $ 0.08 | $ (0.17) | $ (0.09) | $ (0.39)
Research and Development Expense [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Total stock-based compensation | $ (551,156) | $ 698,039 | $ (237,780) | $ 1,281,708
General and Administrative Expense [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Total stock-based compensation | $ (368,956) | $ 653,535 | $ 1,170,094 | $ 1,378,760

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