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Stock-Based Compensation - Stock-Based Compensation Expense (Detail) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total stock-based compensation	$ (920,112)	$ 1,351,574	$ 932,314	$ 2,660,468
Effect on basic and diluted net loss per share	$ 0.08	$ (0.17)	$ (0.09)	$ (0.39)
Research and Development Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total stock-based compensation	$ (551,156)	$ 698,039	$ (237,780)	$ 1,281,708
General and Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total stock-based compensation	$ (368,956)	$ 653,535	$ 1,170,094	$ 1,378,760