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Stock-Based Compensation - Stock-Based Compensation Expense (Detail) - USD ($) | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2016 | Sep. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Total stock-based compensation | $ (189,140) | $ 1,426,242 | $ 743,174 | $ 4,086,710
Effect on basic and diluted net loss per share | $ 0.01 | $ (0.16) | $ (0.06) | $ (0.54)
Research and Development Expense [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Total stock-based compensation |  | $ 781,791 | $ (237,780) | $ 2,063,499
General and Administrative Expense [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Total stock-based compensation | $ (189,140) | $ 644,451 | $ 980,954 | $ 2,023,211

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