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Stock-Based Compensation (Tables) | 9 Months Ended
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Sep. 30, 2016
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] |
Stock-Based Compensation Expense | Our stock-based compensation expense for the three and nine months ended September 30 was as follows:
|  | Three months ended |  |  | Nine months ended |
| September 30, |  |  | September 30, |
|  | 2016 |  |  | 2015 |  |  | 2016 |  |  | 2015 |
Research and development expense |  | $ | — |  |  | $ | 781,791 |  |  | $ | (237,780 | ) |  | $ | 2,063,499 |
General and administrative expense |  |  | (189,140 | ) |  |  | 644,451 |  |  |  | 980,954 |  |  |  | 2,023,211 |
Total stock-based compensation |  | $ | (189,140 | ) |  | $ | 1,426,242 |  |  | $ | 743,174 |  |  | $ | 4,086,710 |
Effect on basic and diluted net loss per share |  | $ | 0.01 |  |  | $ | (0.16 | ) |  | $ | (0.06 | ) |  | $ | (0.54 | )
Stock Option Activity | A summary of our stock option activity for the three months ended September 30, 2016 is as follows:
|  | Number of options |  |  | Weighted-average exercise price ($) per share |
Outstanding options at June 30, 2016 |  |  | 27,831 |  |  |  | 135.64 |
Granted |  |  | — |  |  |  | — |
Exercised |  |  | — |  |  |  | — |
Cancelled |  |  | (7,740 | ) |  |  | 87.60 |
Outstanding options at September 30, 2016 |  |  | 20,091 |  |  |  | 154.15 |
Summary of Changes in Unvested Options | A summary of changes in unvested options for the three months ended September 30, 2016 is as follows:
|  | Number of options |  |  | Weighted-average exercise price ($) per share |  |  | Weighted-average grant date fair value ($) per option |
Unvested options at June 30, 2016 |  |  | 1,250 |  |  |  | 8.52 |  |  |  | 5.53 |
Granted |  |  | — |  |  |  | — |  |  |  | — |
Vested |  |  | — |  |  |  | — |  |  |  | — |
Cancelled |  |  | — |  |  |  | — |  |  |  | — |
Unvested options at September 30, 2016 |  |  | 1,250 |  |  |  | 8.52 |  |  |  | 5.53 |
Summary of Changes in Restricted Stock Units | A summary of changes in our restricted stock units for the three months ended September 30, 2016 is as follows:
|  | Number of RSUs |  |  | Weighted Average Grant Date Fair Value ($) |
Outstanding at June 30, 2016 |  |  | 333,930 |  |  |  | 10.18 |
Granted |  |  | — |  |  |  | — |
Vested and exercised |  |  | (194,620 | ) |  |  | 10.05 |
Cancelled |  |  | (5,834 | ) |  |  | 22.08 |
Outstanding at September 30, 2016 |  |  | 133,476 |  |  |  | 9.87 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure of the changes in outstanding nonvested shares. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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