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Stock-Based Compensation - Stock-Based Compensation Expense (Detail) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total stock-based compensation	$ (189,140)	$ 1,426,242	$ 743,174	$ 4,086,710
Effect on basic and diluted net loss per share	$ 0.01	$ (0.16)	$ (0.06)	$ (0.54)
Research and Development Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total stock-based compensation		$ 781,791	$ (237,780)	$ 2,063,499
General and Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total stock-based compensation	$ (189,140)	$ 644,451	$ 980,954	$ 2,023,211