Cash and Cash Equivalents, and Investments and Fair Value Measurements - Schedule of Available For Sale Securities (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	$ 1,596,002
Fair Value	1,579,162
Cash and cash equivalents:
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	267,731	$ 854,078
Unrealized Gain	0	0
Unrealized Loss	0	0
Fair Value	267,731	854,078
Short-term investments:
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	922,358	692,320
Unrealized Gain	9	40
Unrealized Loss	(6,936)	(579)
Fair Value	915,431	691,781
Long-term investments:
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	445,326	749,377
Unrealized Gain	0	0
Unrealized Loss	(9,913)	(3,384)
Fair Value	435,413	745,993
Commercial paper \| Short-term investments: \| Level 2
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	86,583	124,211
Unrealized Gain	0	2
Unrealized Loss	(443)	(33)
Fair Value	86,140	124,180
Corporate debt securities \| Short-term investments: \| Level 2
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	765,556	552,609
Unrealized Gain	9	36
Unrealized Loss	(6,045)	(546)
Fair Value	759,520	552,099
Corporate debt securities \| Long-term investments: \| Level 2
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	346,032	724,517
Unrealized Gain	0	0
Unrealized Loss	(7,939)	(3,277)
Fair Value	338,093	721,240
U.S. treasury securities \| Short-term investments: \| Level 1
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	54,718
Unrealized Gain	0
Unrealized Loss	(436)
Fair Value	54,282
U.S. treasury securities \| Long-term investments: \| Level 1
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	99,294	24,860
Unrealized Gain	0	0
Unrealized Loss	(1,974)	(107)
Fair Value	97,320	24,753
Agency bonds \| Short-term investments: \| Level 2
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	15,501	15,500
Unrealized Gain	0	2
Unrealized Loss	(12)	0
Fair Value	15,489	15,502
Cash \| Cash and cash equivalents:
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	39,413	30,324
Unrealized Gain	0	0
Unrealized Loss	0	0
Fair Value	39,413	30,324
Money market funds \| Cash and cash equivalents: \| Level 1
Debt Securities, Available-for-sale [Line Items]
Adjusted Cost	228,318	823,754
Unrealized Gain	0	0
Unrealized Loss	0	0
Fair Value	$ 228,318	$ 823,754

Amount, before tax, of unrealized gain in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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