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Income Taxes - Schedule of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
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Deferred tax assets: |  |  |  |
Net operating loss carryforwards | $ 167,203 | $ 156,157 |  |
Research and development tax credit carryforwards | 54,149 | 54,648 |  |
Section 174 capitalized research and development expenses | 39,759 | 53,600 |  |
Stock-based compensation expense | 28,594 | 28,819 |  |
Lease liability | 22,689 | 23,917 |  |
Contingent consideration | 13,437 | 0 |  |
Accrued expenses | 1,788 | 7,032 |  |
Section 163(j) limitation | 1,843 | 5,599 |  |
Depreciation and amortization | 1,223 | 953 |  |
Other | 98 | 132 |  |
Total deferred tax assets | 330,783 | 330,857 |  |
Deferred tax liabilities: |  |  |  |
Depreciation and amortization | 0 | 0 |  |
Right of use assets | (19,822) | (21,115) |  |
Total deferred tax liabilities | (19,822) | (21,115) |  |
Valuation allowance | (310,961) | (309,742) | $ (312,809) | $ (277,370)
Net deferred tax assets | $ 0 | $ 0 |  |

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