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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2025
Income Tax Disclosure [Abstract] |
Schedule of Reconciliation of U.S Federal Statutory Income Tax Rate to Company's Effective Income Tax Rate | A reconciliation of the U.S. federal statutory income tax rate to the Company’s effective income tax rate after the adoption of ASU 2023-09 is as follows:
|  | Year Ended December 31, 2025
|  | Amount |  |  | % |  |
Federal statutory income tax rate |  | $ | 1,202 |  |  |  | 21.0 | % |
State and local income taxes, net of federal income tax effect(1) |  |  | — |  |  |  | — | % |
Tax credits |  |  |  |  |  |  |
Research and development tax credits |  |  | 334 |  |  |  | 5.8 | % |
Changes in valuation allowance |  |  | (3,445 | ) |  |  | (60.2 | )% |
Nontaxable or nondeductible items |  |  |  |  |  |  |
Meals and entertainment |  |  | 14 |  |  |  | 0.3 | % |
Stock-based compensation |  |  | 3,094 |  |  |  | 54.1 | % |
Adjustment to gain on sale of VOWST business |  |  | (1,133 | ) |  |  | (19.8 | )% |
Changes in unrecognized tax benefits |  |  | (67 | ) |  |  | (1.2 | )% |
Other adjustments |  |  | 1 |  |  |  | 0.0 | % |
Effective income tax rate |  | $ | — |  |  |  | — | % |
[1] State and local taxes in Massachusetts comprise the majority of this category. A reconciliation of the U.S. federal statutory income tax rate to the Company’s effective income tax rate for years prior to the adoption of ASU 2023-09 is as follows:
| Year Ended December 31, |  |
|  | 2024 |  |  | 2023 |  |
Federal statutory income tax rate |  |  | (21.0 | )% |  |  | (21.0 | )% |
Research and development tax credits |  |  | (1.8 | ) |  |  | (2.5 | ) |
State taxes, net of federal benefit |  |  | (3.6 | ) |  |  | (7.2 | ) |
Stock-based compensation |  |  | 1.0 |  |  |  | 0.8 |  |
Uncertain tax position reserves |  |  | 0.4 |  |  |  | 0.5 |  |
Other |  |  | (0.4 | ) |  |  | (0.1 | ) |
Change in deferred tax asset valuation allowance |  |  | 25.4 |  |  |  | 29.5 |  |
Effective income tax rate |  |  | — | % |  |  | — | % |
Schedule of Net Deferred Tax Assets | Net deferred tax assets as of December 31, 2025 and 2024 consisted of the following:
|  | December 31, |
|  | 2025 |  |  | 2024 |
Deferred tax assets: |  |  |  |  |  |
Net operating loss carryforwards |  | $ | 167,203 |  |  | $ | 156,157 |
Research and development tax credit carryforwards |  |  | 54,149 |  |  |  | 54,648 |
Section 174 capitalized research and development expenses |  |  | 39,759 |  |  |  | 53,600 |
Stock-based compensation expense |  |  | 28,594 |  |  |  | 28,819 |
Lease liability |  |  | 22,689 |  |  |  | 23,917 |
Contingent consideration |  |  | 13,437 |  |  |  | — |
Accrued expenses |  |  | 1,788 |  |  |  | 7,032 |
Section 163(j) limitation |  |  | 1,843 |  |  |  | 5,599 |
Depreciation and amortization |  |  | 1,223 |  |  |  | 953 |
Other |  |  | 98 |  |  |  | 132 |
Total deferred tax assets |  | $ | 330,783 |  |  | $ | 330,857 |
Deferred tax liabilities: |  |  |  |  |  |
Depreciation and amortization |  |  | — |  |  |  | — |
Right of use assets |  |  | (19,822 | ) |  |  | (21,115 | )
Total deferred tax liabilities |  |  | (19,822 | ) |  |  | (21,115 | )
Valuation allowance |  | $ | (310,961 | ) |  | $ | (309,742 | )
Net deferred tax assets |  | $ | — |  |  | $ | — |
Summary of Changes In Valuation Allowance for Deferred Tax Assets | Changes in the valuation allowance for deferred tax assets during the years ended December 31, 2025, 2024 and 2023 related primarily to the increases or decreases in NOLs, research and development tax credit carryforwards, capitalized research and development expenses pursuant to IRC Section 174, and non-deductible stock-based compensation expenses. A rollforward of the valuation allowance is as follows:
|  | Year Ended December 31, |
|  | 2025 |  |  | 2024 |  |  | 2023 |
Valuation allowance at beginning of year |  | $ | (309,742 | ) |  | $ | (312,809 | ) |  | $ | (277,370 | )
Decreases recorded as benefit to income tax provision |  |  |  |  |  | 3,067 |  |  |  | — |
Increases recorded to income tax provision |  |  | (1,219 | ) |  |  | — |  |  |  | (35,439 | )
Valuation allowance as of end of year |  | $ | (310,961 | ) |  | $ | (309,742 | ) |  | $ | (312,809 | )
Schedule of Change In Unrecognized Tax Benefits Roll Forward | The changes in the Company's unrecognized tax benefits for the years ended December 31, 2025, 2024, and 2023 were as follows:
|  | Year Ended December 31, |
|  | 2025 |  |  | 2024 |  |  | 2023 |
Balance at beginning of year |  | $ | 14,015 |  |  | $ | 13,529 |  |  | $ | 12,528 |
Increase in unrecognized tax benefits as a result of tax positions taken during the year |  |  | 129 |  |  |  | 486 |  |  |  | 1,001 |
(Decrease) in unrecognized tax benefits as a result of tax positions taken during the year |  |  | (289 | ) |  |  | — |  |  |  | — |
Reduction to unrecognized tax benefits |  |  | — |  |  |  | — |  |  |  | — |
Balance at end of year |  | $ | 13,855 |  |  | $ | 14,015 |  |  | $ | 13,529 |

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