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v3.25.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
Cash flows from operating activities: |  |  |  |
Net Income (Loss) |  | $ 5,696 | $ 136 | $ (113,724)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |
Stock-based compensation expense |  | 10,840 | 20,971 | 34,101
Depreciation and amortization expense |  | 4,133 | 5,468 | 6,243
Non-cash operating lease cost |  | 8,420 | 9,230 | 8,871
Net (accretion) amortization of (discounts) premiums on investments |  | 0 | 0 | (236)
Gain on sale of VOWST Business, net of transaction costs |  | 0 | (146,707) | 0
Amortization of debt issuance costs |  | 0 | 1,413 | 1,139
Loss associated with extinguishment of debt |  | 0 | 23,351 | 1,625
(Gain)/loss on disposal of fixed assets |  | (192) | 317 | 0
Impairment of long-lived assets |  | 0 | 3,267 | 0
Change in fair value of warrant liabilities |  | 0 | (546) | (1,554)
Collaboration (profit) loss sharing - related party (1) | [1] | 0 | 0 | 5,158
Changes in operating assets and liabilities: |  |  |  |
Accounts receivable due from SPN - related party |  | 1,708 | (2,068) | 0
Prepaid expenses and other current and non-current assets |  | 2,720 | 987 | (29,124)
Accounts receivable |  | (157) | 0 | 0
Collaboration receivable - related party |  | 0 | 8,674 | (8,674)
Inventories |  | 0 | (33,795) | (29,647)
Deferred income - related party |  | 0 | (4,124) | 7,730
Deferred revenue - related party |  | 0 | 0 | (1,325)
Accounts payable |  | (2,397) | (2,940) | (11,578)
Accrued liabilities due to SPN - related party |  | (14,472) | (15,708) | 0
Operating lease liabilities |  | (8,674) | (6,339) | (2,197)
Accrued expenses and other current and long-term liabilities |  | (6,508) | (10,196) | 15,838
Net cash provided by (used in) operating activities |  | 1,117 | (148,609) | (117,354)
Cash flows from investing activities: |  |  |  |
Purchases of property and equipment |  | (252) | (380) | (7,975)
Proceeds from sales of property and equipment |  | 210 | 0 | 0
Purchases of investments |  | 0 | 0 | (4,426)
Sales and maturities of investments |  | 0 | 0 | 22,983
Sales of restricted investments |  | 0 | 1,401 | 0
Proceeds from sale of VOWST Business |  | 0 | 141,272 | 0
Net cash (used in) provided by investing activities |  | (42) | 142,293 | 10,582
Cash flows from financing activities: |  |  |  |
Proceeds from at the market equity offering, net of issuance costs |  | 13,167 | 23,530 | 18,159
Proceeds from exercise of stock options |  | 501 | 0 | 877
Proceeds from Securities Purchase Agreement - related party |  | 0 | 13,516 | 0
Issuance of common stock under ESPP |  | 230 | 487 | 2,151
Proceeds from issuance of debt, net of issuance costs |  | 0 | 0 | 103,378
Repayment of notes payable |  | 0 | (127,905) | (52,860)
Net cash provided by (used in) financing activities |  | 13,898 | (90,372) | 71,705
Net increase (decrease) in cash, cash equivalents and restricted cash |  | 14,973 | (96,688) | (35,067)
Effect of exchange rate changes on cash, cash equivalents and restricted cash |  | 0 | (1) | 2
Cash, cash equivalents and restricted cash at beginning of year |  | 39,461 | 136,150 | 171,215
Cash, cash equivalents and restricted cash at end of year |  | 54,434 | 39,461 | 136,150
Supplemental disclosure of cash flow information: |  |  |  |
Cash paid for interest |  | 0 | 10,858 | 12,547
Supplemental disclosure of non-cash investing and financing activities: |  |  |  |
Property and equipment purchases included in accounts payable and accrued expenses |  | 0 | 0 | 16
Lease liability arising from obtaining right-of-use assets |  | 0 | 0 | 3,046
Prepaid rent reclassified to right-of-use assets |  | 0 | 0 | 4,634
Recognition of warrant liabilities |  | 0 | 0 | 2,100
Warrants issued related to prior credit facility with Oaktree and recorded as debt discount |  | $ 0 | $ 0 | $ 2,785
[1] | Includes non-cash collaboration profits and losses related to pre-launch activities; subsequent to the approval of VOWST in April 2023, collaboration (profit) loss sharing - related party is included within changes in operating assets and liabilities.

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