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Income Taxes - Summary of Changes In Valuation Allowance for Deferred Tax Assets (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
Valuation Allowance [Abstract] |  |  |
Valuation allowance at beginning of year | $ (309,742) | $ (312,809) | $ (277,370)
Decreases recorded as benefit to income tax provision |  | 3,067 |
Increases recorded to income tax provision | (1,219) |  | (35,439)
Valuation allowance as of end of year | $ (310,961) | $ (309,742) | $ (312,809)

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- Definition Decrease in valuation allowance deferred tax asset amount. + References No definition available. + Details
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Namespace Prefix: | mcrb_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

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- Definition Increase in valuation allowance deferred tax asset. + References No definition available. + Details
Name: | mcrb_IncreaseInValuationAllowanceDeferredTaxAsset
Namespace Prefix: | mcrb_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

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- Definition Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-2 + Details
Name: | us-gaap_DeferredTaxAssetsValuationAllowance
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

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- References No definition available. + Details
Name: | us-gaap_ValuationAllowanceAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration