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Income Taxes - Additional Information (Detail) - USD ($) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Income Tax Disclosure [Line Items] |  |  |  |
Income tax expense (benefit) | $ 0 | $ 0 | $ 0 |
Unamortized research and experimental expenditures acceleration period | one or two years |  |  |
Percentage of research and experimental expense | 100.00% |  |  |
Cash payments or refunds for income taxes | $ 0 |  |  |
Unrecognized tax benefits | $ 13,855,000 | $ 14,015,000 | $ 13,529,000 | $ 12,528,000
Massachusetts [Member] |  |  |  |
Income Tax Disclosure [Line Items] |  |  |  |
Net operating loss carry forwards, expiration year, start | 2035 |  |  |
Future Tax Years [Member] | Maximum [Member] |  |  |  |
Income Tax Disclosure [Line Items] |  |  |  |
Taxable income on NOL | 80.00% |  |  |
Federal [Member] |  |  |  |
Income Tax Disclosure [Line Items] |  |  |  |
Net operating loss carryforwards | $ 616,412,000 |  |  |
Research and development performance period | 5 years |  |  |
Federal [Member] | Before 2018 [Member] |  |  |  |
Income Tax Disclosure [Line Items] |  |  |  |
Net operating loss carryforwards | $ 98,756,000 |  |  |
Net operating loss carry forwards, expiration year, start | 2035 |  |  |
Federal [Member] | After 2017 [Member] |  |  |  |
Income Tax Disclosure [Line Items] |  |  |  |
Net operating loss carryforwards | $ 517,656,000 |  |  |
Federal [Member] | Research and Development Tax Credit [Member] |  |  |  |
Income Tax Disclosure [Line Items] |  |  |  |
Tax credit carryforwards | $ 55,341,000 |  |  |
Tax credit carryforwards, expiration year, start | 2031 |  |  |
Federal [Member] | Orphan Drug Credit Carryforwards [Member] |  |  |  |
Income Tax Disclosure [Line Items] |  |  |  |
Tax credit carryforwards | $ 25,876,000 |  |  |
Foreign [Member] |  |  |  |
Income Tax Disclosure [Line Items] |  |  |  |
Research and development performance period | 15 years |  |  |
State [Member] |  |  |  |
Income Tax Disclosure [Line Items] |  |  |  |
Net operating loss carryforwards | $ 597,758,000 |  |  |
State [Member] | Research and Development Tax Credit [Member] |  |  |  |
Income Tax Disclosure [Line Items] |  |  |  |
Tax credit carryforwards | $ 14,767,000 |  |  |
Tax credit carryforwards, expiration year, start | 2028 |  |  |

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