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Income Taxes - Schedule of Reconciliation of U.S Federal Statutory Income Tax Rate to Company's Effective Income Tax Rate (Detail) - USD ($) | 12 Months Ended
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Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
Income Tax Disclosure [Abstract] |  |  |  |  |
Federal statutory income tax rate |  | $ 1,202,000 |  |  |
Federal statutory income tax rate percent |  | (21.00%) |  | (21.00%) | (21.00%)
Research and development tax credits |  | $ 334,000 |  |  |
Research and development tax credits percent |  | 5.80% |  | (1.80%) | (2.50%)
State and local income taxes, net of federal income tax effect | [1] | $ 0 |  |  |
State and local income taxes, net of federal income tax effect percent |  | 0.00% | [1] | (3.60%) | (7.20%)
Nontaxable or nondeductible items |  |  |  |  |
Meals and entertainment |  | $ 14,000 |  |  |
Meals and entertainment percent |  | 0.30% |  |  |
Stock-based compensation |  | $ 3,094,000 |  |  |
Stock-based compensation percent |  | 54.10% |  | 1.00% | 0.80%
Adjustment to gain on sale of VOWST business |  | $ (1,133,000) |  |  |
Adjustment to gain on sale of VOWST business percent |  | (19.80%) |  |  |
Uncertain tax position reserves percent |  |  |  | 0.40% | 0.50%
Changes in unrecognized tax benefits |  | $ (67,000) |  |  |
Changes in unrecognized tax benefits percent |  | (1.20%) |  |  |
Other adjustments |  | $ 1,000 |  |  |
Other adjustments percent |  | 0.00% |  | (0.40%) | (0.10%)
Change in deferred tax asset valuation allowance |  | $ (3,445,000) |  |  |
Change in deferred tax asset valuation allowance percent |  | (60.20%) |  | 25.40% | 29.50%
Effective income tax rate |  | $ 0 |  | $ 0 | $ 0
Effective income tax rate percent |  | 0.00% |  | 0.00% | 0.00%
[1] | State and local taxes in Massachusetts comprise the majority of this category.

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- Definition Amount of difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying statutory federal (national) tax rate to pretax income (loss) from continuing operation attributable to other reconciling item. Excludes state and local income tax expense (benefit), federal tax expense (benefit), statutory income tax expense (benefit) outside of country of domicile, tax credit, nondeductible expense, deduction, income tax settlement, income tax contingency, and cross-border tax law. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12 -Subparagraph (b)(3) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12 + Details
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