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Stock and Stock-Based Awards (Tables) | 12 Months Ended
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Dec. 31, 2025
Subsidiary, Sale of Stock [Line Items] |
Summary of Stock Option Activity | The following table summarizes the Company’s stock option activity for the year ended December 31, 2025:
|  | Number of Shares |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term |  |  | Aggregate Intrinsic Value |
|  |  |  |  |  |  |  | (in years) |  |  |  |
Outstanding as of December 31, 2024 |  |  | 886,123 |  |  | $ | 114.47 |  |  |  | 6.59 |  |  | $ | 87 |
Granted |  |  | 546,805 |  |  | $ | 15.14 |  |  |  |  |  |  |
Exercised |  |  | (23,900 | ) |  | $ | 20.96 |  |  |  |  |  |  |
Forfeited |  |  | (284,820 | ) |  | $ | 114.77 |  |  |  |  |  |  |
Outstanding as of December 31, 2025 |  |  | 1,124,208 |  |  | $ | 68.07 |  |  |  | 7.17 |  |  | $ | 228 |
Vested and expected to vest as of December 31, 2025 |  |  | 1,124,208 |  |  | $ | 68.07 |  |  |  | 7.17 |  |  | $ | 228 |
Options exercisable as of December 31, 2025 |  |  | 502,733 |  |  | $ | 129.06 |  |  |  | 5.15 |  |  | $ | 31 |
Summary of Restricted and Performance Stock Unit Activity | The table below summarizes the Company’s RSU and PSU activity for the year ended December 31, 2025:
|  | Number of Shares |  |  | Weighted Average Grant Date Fair Value |
Unvested restricted stock units as of December 31, 2024 |  |  | 81,459 |  |  | $ | 55.36 |
Granted |  |  | 79,846 |  |  | $ | 18.29 |
Forfeited |  |  | (12,300 | ) |  | $ | 62.76 |
Vested |  |  | (124,855 | ) |  | $ | 30.54 |
Unvested restricted stock units as of December 31, 2025 |  |  | 24,150 |  |  | $ | 57.31 |
Summary of Stock Based Compensation Expense | The Company recorded stock-based compensation expense related to stock options and restricted stock units in the following expense categories of its consolidated statements of operations and comprehensive income (loss):
|  | Year Ended December 31, |
|  | 2025 |  |  | 2024 |  |  | 2023 |
Research and development expenses |  | $ | 5,080 |  |  | $ | 10,996 |  |  | $ | 19,341 |
General and administrative expenses |  |  | 5,760 |  |  |  | 9,975 |  |  |  | 14,760 |
|  | $ | 10,840 |  |  | $ | 20,971 |  |  | $ | 34,101 |
Employees Stock Option [Member] |
Subsidiary, Sale of Stock [Line Items] |
Summary of Estimated Fair Value of Employee Stock Options | The assumptions that the Company used to determine the fair value of the stock options granted to employees and directors were as follows, presented on a weighted average basis:
|  | Year Ended December 31, |
|  | 2025 |  |  | 2024 |  |  | 2023 |
Risk-free interest rate |  |  | 4.26 | % |  |  | 2.70 | % |  |  | 3.64 | %
Expected term (in years) |  |  | 6.0 |  |  |  | 6.0 |  |  |  | 6.0 |
Expected volatility |  |  | 121.0 | % |  |  | 76.2 | % |  |  | 107.2 | %
Expected dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Employee Stock [Member] |
Subsidiary, Sale of Stock [Line Items] |
Summary of Estimated Fair Value of Employee Stock Options | The assumptions that the Company used to determine the fair value of rights to acquire common stock under the ESPP were as follows, presented on a weighted average basis:
|  | Year Ended December 31, |
|  | 2025 |  |  | 2024 |  |  | 2023 |
Risk-free interest rate |  |  | 4.34 | % |  |  | 5.16 | % |  |  | 5.01 | %
Expected term (in years) |  |  | 0.5 |  |  |  | 0.5 |  |  |  | 0.5 |
Expected volatility |  |  | 115.8 | % |  |  | 118.3 | % |  |  | 79.1 | %
Expected dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %

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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Disclosure of the number and weighted-average grant date fair value for restricted stock and restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock and restricted stock units that were granted, vested, or forfeited during the year. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(2) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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