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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
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Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
Pay vs Performance Disclosure |  |  |
Pay vs Performance Disclosure, Table | P ay Versus Performance In accordance with the SEC’s disclosure requirements regarding pay versus performance, this section presents the SEC-defined “Compensation Actually Paid,” or CAP. Also required by the SEC, this section compares CAP to various measures used to gauge our performance. CAP is a supplemental measure to be viewed alongside performance measures as an addition to the philosophy and strategy of compensation-setting discussed elsewhere in this proxy statement, not in replacement. Pay Versus Performance Table The following table sets forth information concerning the compensation of our NEOs for each of the fiscal years ended December 31, 2023, 2024 and 2025, and our financial performance for each such fiscal year:
Year | Summary Compensation Table Total for Eric D. Shaff ($) |  | Compensation Actually Paid to Eric D. Shaff ($)(1)(2) |  | Summary Compensation Table Total for Thomas J. DesRosier ($) |  | Compensation Actually Paid to Thomas J. DesRosier ($)(1)(2) |  | Summary Compensation Table Total for Marella Thorell ($) |  | Compensation Actually Paid to Marella Thorell ($)(1)(2) |  | Average Summary Compensation Table Total for Non-PEO NEOs ($) |  | Average Compensation Actually Paid to Non-PEO NEOs ($)(1)(2) |  | Value of Initial Fixed $100 Investment Based on Total Shareholder Return ($) |  | Net Income ($) |
2025 | $ | 1,775,549 |  | $ | 1,445,792 |  | $ | 1,136,023 |  | $ | 1,026,058 |  | $ | 1,113,396 |  | $ | 962,202 |  | $ | 1,017,905 |  | $ | 900,283 |  | $ | 13 |  | $ | 5,696,000 |
2024 | $ | 2,682,007 |  | $ | 1,906,325 |  | $ | 0 |  | $ | 0 |  | $ | 0 |  | $ | 0 |  | $ | 1,259,430 |  | $ | 988,400 |  | $ | 15 |  | $ | 136,000 |
2023 | $ | 3,158,336 |  | $ | (517,565 | ) | $ | 0 |  | $ | 0 |  | $ | 0 |  | $ | 0 |  | $ | 1,695,799 |  | $ | 260,831 |  | $ | 25 |  | $ | (113,724,000 | )
(1) Amounts represent compensation actually paid to our PEO and the average compensation actually paid to our remaining NEOs for the relevant fiscal year, as determined under SEC rules (and described below), which includes the individuals indicated in the table below for each fiscal year:
Year | PEO | Non-PEO NEOs
2025 | Eric Shaff, Thomas DesRosier and Marella Thorell | Matthew Henn, Ph.D. and Teresa L. Young, Ph.D.
2024 | Eric Shaff | Lisa von Moltke, M.D., and Thomas DesRosier.
2023 | Eric Shaff | Teresa L. Young, Ph.D. and Lisa von Moltke, M.D
Compensation actually paid to our NEOs represents the “Total” compensation reported in the Summary Compensation Table for the applicable fiscal year, as adjusted as follows:
Adjustments | 2025 |
| Eric D. Shaff |  | Thomas J. DesRosier |  | Marella Thorell |  | Average Non-PEO NEOs |
Deduction for Amounts Reported under the “Stock Awards” and “Option Awards” Columns in the Summary Compensation Table for Applicable FY |  | (1,338,870 | ) |  | (446,290 | ) |  | (446,290 | ) |  | (521,972 | )
Increase Based on ASC 718 Fair Value of Awards Granted during Applicable FY that Remain Unvested as of Applicable FY End, Determined as of Applicable FY End |  | 1,164,160 |  |  | 388,053 |  |  | 388,053 |  |  | 388,053 |
Increase Based on ASC 718 Fair Value of Awards Granted during Applicable FY that Vested during Applicable FY, Determined as of Vesting Date |  | 0 |  |  |  |  |  |  | 66,607 |
Increase/deduction for Awards Granted during Prior FY that were Outstanding and Unvested as of Applicable FY End, Determined Based on Change in ASC 718 Fair Value from Prior FY End to Applicable FY End |  | (108,809 | ) |  | (37,316 | ) |  | (53,912 | ) |  | (36,095 | )
Increase/deduction for Awards Granted during Prior FY that Vested During Applicable FY, Determined Based on Change in ASC 718 Fair Value from Prior FY End to Vesting Date |  | (46,238 | ) |  | (14,412 | ) |  | (39,045 | ) |  | (14,215 | )
Deduction of ASC 718 Fair Value of Awards Granted during Prior FY that were Forfeited during Applicable FY, Determined as of Prior FY End |  | 0 |  |  |  |  |  |  | 0 |
Increase Based on Dividends or Other Earnings Paid during Applicable FY prior to Vesting Date |  | 0 |  |  |  |  |  |  | 0 |
Increase Based on Incremental Fair Value of Options/SARs Modified during Applicable FY |  | 0 |  |  |  |  |  |  | 0 |
Deduction for Change in the Actuarial Present Values Reported under the “Change in Pension Value and Nonqualified Deferred Compensation Earnings” Column of the Summary Compensation Table for Applicable FY |  | 0 |  |  |  |  |  |  | 0 |
Increase for Service Cost and, if Applicable, Prior Service Cost for Pension Plans |  | 0 |  |  |  |  |  |  | 0 |
TOTAL ADJUSTMENTS |  | (329,757 | ) |  | (109,965 | ) |  | (151,194 | ) |  | (117,622 | )
(2) Fair value or change in fair value, as applicable, of equity awards in the “Compensation Actually Paid” columns was determined by reference to (i) for solely service-vesting RSU awards, the closing price per share on the applicable year-end date(s) or, in the case of vesting dates, the closing price per share on the applicable vesting date(s); (ii) for performance-based RSU awards, the same valuation methodology as RSU awards above except that the year-end values are multiplied by the probability of achievement of the applicable performance objective as of the applicable date; and (iii) for stock options, a Black Scholes value as of the applicable year-end or vesting date(s), determined based on the same methodology as used to determine grant date fair value but using the closing stock price on the applicable revaluation date as the current market price and with an expected life set equal to the original expected life determined at grant, reduced by the amount of time elapsed from the grant date to the revaluation date, and adjusted based on relevant factors, including taking into account the stock price on the applicable revaluation date relative to the option’s strike price determined at grant, and in all cases based on volatility and risk free rates determined as of the revaluation date based on the expected life period and based on an expected dividend rate of 0%. For additional information on the assumptions used to calculate the valuation of the awards, see the Notes to Consolidated Financial Statements in our Annual Report on Form 10-K for the fiscal year ended December 31, 2025 and prior fiscal years. |  |
Named Executive Officers, Footnote | (1) Amounts represent compensation actually paid to our PEO and the average compensation actually paid to our remaining NEOs for the relevant fiscal year, as determined under SEC rules (and described below), which includes the individuals indicated in the table below for each fiscal year:
Year | PEO | Non-PEO NEOs
2025 | Eric Shaff, Thomas DesRosier and Marella Thorell | Matthew Henn, Ph.D. and Teresa L. Young, Ph.D.
2024 | Eric Shaff | Lisa von Moltke, M.D., and Thomas DesRosier.
2023 | Eric Shaff | Teresa L. Young, Ph.D. and Lisa von Moltke, M.D
Adjustment To PEO Compensation, Footnote | Compensation actually paid to our NEOs represents the “Total” compensation reported in the Summary Compensation Table for the applicable fiscal year, as adjusted as follows:
Adjustments | 2025 |
| Eric D. Shaff |  | Thomas J. DesRosier |  | Marella Thorell |  | Average Non-PEO NEOs |
Deduction for Amounts Reported under the “Stock Awards” and “Option Awards” Columns in the Summary Compensation Table for Applicable FY |  | (1,338,870 | ) |  | (446,290 | ) |  | (446,290 | ) |  | (521,972 | )
Increase Based on ASC 718 Fair Value of Awards Granted during Applicable FY that Remain Unvested as of Applicable FY End, Determined as of Applicable FY End |  | 1,164,160 |  |  | 388,053 |  |  | 388,053 |  |  | 388,053 |
Increase Based on ASC 718 Fair Value of Awards Granted during Applicable FY that Vested during Applicable FY, Determined as of Vesting Date |  | 0 |  |  |  |  |  |  | 66,607 |
Increase/deduction for Awards Granted during Prior FY that were Outstanding and Unvested as of Applicable FY End, Determined Based on Change in ASC 718 Fair Value from Prior FY End to Applicable FY End |  | (108,809 | ) |  | (37,316 | ) |  | (53,912 | ) |  | (36,095 | )
Increase/deduction for Awards Granted during Prior FY that Vested During Applicable FY, Determined Based on Change in ASC 718 Fair Value from Prior FY End to Vesting Date |  | (46,238 | ) |  | (14,412 | ) |  | (39,045 | ) |  | (14,215 | )
Deduction of ASC 718 Fair Value of Awards Granted during Prior FY that were Forfeited during Applicable FY, Determined as of Prior FY End |  | 0 |  |  |  |  |  |  | 0 |
Increase Based on Dividends or Other Earnings Paid during Applicable FY prior to Vesting Date |  | 0 |  |  |  |  |  |  | 0 |
Increase Based on Incremental Fair Value of Options/SARs Modified during Applicable FY |  | 0 |  |  |  |  |  |  | 0 |
Deduction for Change in the Actuarial Present Values Reported under the “Change in Pension Value and Nonqualified Deferred Compensation Earnings” Column of the Summary Compensation Table for Applicable FY |  | 0 |  |  |  |  |  |  | 0 |
Increase for Service Cost and, if Applicable, Prior Service Cost for Pension Plans |  | 0 |  |  |  |  |  |  | 0 |
TOTAL ADJUSTMENTS |  | (329,757 | ) |  | (109,965 | ) |  | (151,194 | ) |  | (117,622 | )
Non-PEO NEO Average Total Compensation Amount | $ 1,017,905 | $ 1,259,430 | $ 1,695,799
Non-PEO NEO Average Compensation Actually Paid Amount | $ 900,283 | 988,400 | 260,831
Compensation Actually Paid vs. Total Shareholder Return | Relationship Between Financial Performance Measures The graphs below compare the compensation actually paid to our PEO and the average of the compensation actually paid to our remaining NEOs, with (i) our cumulative TSR, and (ii) our net income, in each case, for the fiscal years ended December 31, 2023, 2024 and 2025. TSR amounts reported in the graph assume an initial fixed investment of $100. |  |
Compensation Actually Paid vs. Net Income | Relationship Between Financial Performance Measures The graphs below compare the compensation actually paid to our PEO and the average of the compensation actually paid to our remaining NEOs, with (i) our cumulative TSR, and (ii) our net income, in each case, for the fiscal years ended December 31, 2023, 2024 and 2025. TSR amounts reported in the graph assume an initial fixed investment of $100. |  |
Total Shareholder Return Amount | $ 13 | 15 | 25
Net Income (Loss) | 5,696,000 | $ 136,000 | $ (113,724,000)
PEO Name |  | Eric Shaff | Eric Shaff
Eric D. Shaff [member] |  |  |
Pay vs Performance Disclosure |  |  |
PEO Total Compensation Amount | 1,775,549 | $ 2,682,007 | $ 3,158,336
PEO Actually Paid Compensation Amount | $ 1,445,792 | 1,906,325 | (517,565)
PEO Name | Eric Shaff |  |
Thomas J. DesRosier [Member] |  |  |
Pay vs Performance Disclosure |  |  |
PEO Total Compensation Amount | $ 1,136,023 | 0 | 0
PEO Actually Paid Compensation Amount | $ 1,026,058 | 0 | 0
PEO Name | Thomas DesRosier |  |
Marella Thorell [Member] |  |  |
Pay vs Performance Disclosure |  |  |
PEO Total Compensation Amount | $ 1,113,396 | 0 | 0
PEO Actually Paid Compensation Amount | $ 962,202 | $ 0 | $ 0
PEO Name | Marella Thorell |  |
PEO | Eric D. Shaff [member] |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | $ (329,757) |  |
PEO | Eric D. Shaff [member] | Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
PEO | Eric D. Shaff [member] | Aggregate Pension Adjustments Service Cost |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
PEO | Eric D. Shaff [member] | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (1,338,870) |  |
PEO | Eric D. Shaff [member] | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 1,164,160 |  |
PEO | Eric D. Shaff [member] | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (108,809) |  |
PEO | Eric D. Shaff [member] | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
PEO | Eric D. Shaff [member] | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (46,238) |  |
PEO | Eric D. Shaff [member] | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
PEO | Eric D. Shaff [member] | Deduction of ASC 718 Fair Value of Awards Granted During Prior FY that were Forfeited [Member] |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
PEO | Eric D. Shaff [member] | Increase Based on Incremental Fair Value of Options/SARs Modified During Applicable FY [Member] |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
PEO | Thomas J. DesRosier [Member] |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (109,965) |  |
PEO | Thomas J. DesRosier [Member] | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (446,290) |  |
PEO | Thomas J. DesRosier [Member] | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 388,053 |  |
PEO | Thomas J. DesRosier [Member] | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (37,316) |  |
PEO | Thomas J. DesRosier [Member] | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (14,412) |  |
PEO | Marella Thorell [Member] |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (151,194) |  |
PEO | Marella Thorell [Member] | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (446,290) |  |
PEO | Marella Thorell [Member] | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 388,053 |  |
PEO | Marella Thorell [Member] | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (53,912) |  |
PEO | Marella Thorell [Member] | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (39,045) |  |
Non-PEO NEO |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (117,622) |  |
Non-PEO NEO | Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
Non-PEO NEO | Aggregate Pension Adjustments Service Cost |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (521,972) |  |
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 388,053 |  |
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (36,095) |  |
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 66,607 |  |
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (14,215) |  |
Non-PEO NEO | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
Non-PEO NEO | Deduction of ASC 718 Fair Value of Awards Granted During Prior FY that were Forfeited [Member] |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
Non-PEO NEO | Increase Based on Incremental Fair Value of Options/SARs Modified During Applicable FY [Member] |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | $ 0 |  |

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