<SEC-DOCUMENT>0001104659-24-088546.txt : 20240812
<SEC-HEADER>0001104659-24-088546.hdr.sgml : 20240812
<ACCEPTANCE-DATETIME>20240812214917
ACCESSION NUMBER:		0001104659-24-088546
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20240812
FILED AS OF DATE:		20240812
DATE AS OF CHANGE:		20240812

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Zabrowski Dan
		CENTRAL INDEX KEY:			0001940818
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-42139
		FILM NUMBER:		241198558

	MAIL ADDRESS:	
		STREET 1:		C/O APEXIGEN INC
		STREET 2:		75 SHOREWAY ROAD, SUITE C
		CITY:			SAN CARLOS
		STATE:			CA
		ZIP:			94070

	FORMER NAME:	
		FORMER CONFORMED NAME:	Zabrowksi Dan
		DATE OF NAME CHANGE:	20220802

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ACTUATE THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001652935
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				473044785
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1751 RIVER RUN
		STREET 2:		SUITE 400
		CITY:			FORT WORTH
		STATE:			TX
		ZIP:			76107
		BUSINESS PHONE:		847-986-4190

	MAIL ADDRESS:	
		STREET 1:		1751 RIVER RUN
		STREET 2:		SUITE 400
		CITY:			FORT WORTH
		STATE:			TX
		ZIP:			76107

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Apotheca Therapeutics, Inc.
		DATE OF NAME CHANGE:	20150911
</SEC-HEADER>
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<TYPE>3
<SEQUENCE>1
<FILENAME>tm2420079-5_3seq1.xml
<DESCRIPTION>OWNERSHIP DOCUMENT
<TEXT>
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<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2024-08-12</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001652935</issuerCik>
        <issuerName>ACTUATE THERAPEUTICS, INC.</issuerName>
        <issuerTradingSymbol>ACTU</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001940818</rptOwnerCik>
            <rptOwnerName>Zabrowski Dan</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ACTUATE THERAPEUTICS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1751 RIVER RUN, SUITE 400</rptOwnerStreet2>
            <rptOwnerCity>FORT WORTH</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>76107</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>76348</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Catharine A. Zabrowski Irrevocable Trust</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Non-Qualified Stock Options</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>2.14</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2033-08-30</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>15942</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Catharine A. Zabrowski Irrevocable Trust</value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Represents shares held by the Catharine A. Zabrowski Irrevocable Trust, of which Catherine A. Zabrowski, the wife of the reporting person, is the trustee and has sole voting and investment power over such shares and options. The reporting person may be deemed to have or share such investment and/or voting power due to the trustee's status as his spouse. The reporting person disclaims beneficial ownership of such shares other than to the extent he may have a pecuniary interest therein.</footnote>
        <footnote id="F2">15,942 stock options, which are held by the Catharine A. Zabrowski Irrevocable Trust, that are exercisable for shares of common stock of the issuer were fully vested as of April 30, 2024.</footnote>
    </footnotes>

    <remarks>Exhibit List Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Paul Lytle, Attorney-in-Fact</signatureName>
        <signatureDate>2024-08-12</signatureDate>
    </ownerSignature>
</ownershipDocument>
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<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>tm2420079d5_ex24.htm
<DESCRIPTION>EXHIBIT 24
<TEXT>
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<HEAD>
     <TITLE></TITLE>
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<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="text-align: right; margin: 0"><FONT STYLE="font-size: 10pt"><B>Exhibit 24</B></FONT></P>

<P STYLE="margin: 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt"><B>POWER OF ATTORNEY</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="font-size: 10pt">Know all by these
present, that the undersigned does hereby constitute and appoint Paul Lytle, Janis Penman, Janet Spreen, Brittany Stevenson and Michael
Gunther, and each of them, as the undersigned&rsquo;s true and lawful attorneys-in-fact and agents to do any and all things, and execute
any or all instruments which, after the advice of counsel, said attorneys and agents may deem necessary and advisable to enable the undersigned
to comply with the Securities Exchange Act of 1934, as amended, and any rules, regulations and requirements of the Securities and Exchange
Commission (&ldquo;SEC&rdquo;), including specifically, but without limitation thereof, power of attorney to sign the undersigned&rsquo;s
name to a Form&nbsp;ID, Form&nbsp;144, Form&nbsp;3, Form&nbsp;4, Form&nbsp;5, Schedule 13D or Schedule 13G and any amendments thereto,
to be filed with the SEC; and the undersigned does hereby ratify and confirm all that any of said attorneys and agents shall do or cause
to be done by virtue hereof. The undersigned may revoke the authority granted herein upon delivering a signed written notice to the foregoing
attorneys-in-fact.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Executed on this 13th day of June, 2024.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 50%"><FONT STYLE="font-size: 10pt">/s/
    Dan Zabrowski</FONT></TD>
    <TD STYLE="width: 50%"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">Name: Dan Zabrowski</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD></TR>
  </TABLE>


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