<DOCUMENT>
<TYPE>EX-24.3_456147
<SEQUENCE>2
<FILENAME>poa.txt
<DESCRIPTION>POA DOCUMENT
<TEXT>
POWER OF ATTORNEY
Know all by these presents, that the undersigned hereby
constitutes and appoints Sandra Thomson, the undersigned's true
and lawful attorney in-fact to:

(1) execute for and on behalf of the undersigned, in the
undersigned's capacity as an officer and/or director of
OncoGenex Pharmaceuticals, Inc. (the "Company"), Forms 3, 4
and 5 (including amendments thereto) in accordance with
Section 16(a) of the Securities Exchange Act of 1934, as
amended (the "Exchange Act"), and the rules and
regulations thereunder and a Form ID, Uniform Application
for Access Codes to File on Edgar (collectively, "Forms");

(2) do and perform any and all acts for and on behalf of
the undersigned which may be necessary or desirable to
complete, execute and timely file any and all such Forms
with the United States Securities and Exchange Commission
and any stock exchange or similar authority; and

(3) take any other action of any type whatsoever in
connection with the foregoing which, in the opinion of such
attorney-in-fact, may be of benefit to, in the best
interest of, or legally required by, the undersigned, it
being understood that the documents executed by such
attorney-in-fact on behalf of the undersigned pursuant to
this Power of Attorney shall be in such form and shall
contain such terms and conditions as such attorney-in-
fact may approve in such attorney-in-fact's discretion.

The undersigned hereby grants to such attorney-in-fact full
power and authority to do and perform any and every act and
thing whatsoever requisite, necessary or proper to be done in
the exercise of any of the rights and powers herein granted,
as fully to all intents and purposes as the undersigned might
or could do if personally present, with full power of
substitution or revocation, hereby ratifying and confirming
all that such attorney-in-fact, or such attorney-in-fact's
substitute or substitutes, shall lawfully do or cause to be done
by virtue of this power of attorney and the rights and powers
herein granted.  The undersigned acknowledges that such
attorney-in-fact, in serving in such capacity at the request
of the undersigned, is not assuming, nor is the Company
assuming, any of the undersigned's responsibilities to comply
with Section 16 of the Exchange Act.

The undersigned agrees that each such attorney-in-fact herein
may rely entirely on information furnished orally or in writing
by the undersigned to such attorney-in-fact.  The undersigned
also agrees to indemnify and hold harmless the Company and such
attorney-in-fact against any losses, claims, damages or
liabilities (or actions in these respects) that arise out of or
are based upon any untrue statements or omission of necessary
facts in the information provided by the undersigned to such
attorney-in fact for purposes of executing, acknowledging,
delivering or filing such Forms and agrees to reimburse the
Company and such attorney-in-fact for any legal or other
expenses reasonably incurred in connection with investigating
or defending against any such loss, claim, damage, liability or
action.
This Power of Attorney supersedes any power of attorney
previously executed by the undersigned regarding the
purposes outlined in the first paragraph hereof ("Prior
Powers of Attorney"), and the authority of the attorney-
in-fact named in any Prior Powers of Attorney is hereby
revoked.
This Power of Attorney shall remain in full force and
effect until the undersigned is no longer required to file
any such Forms with respect to the undersigned's holdings
of and transactions in securities issued by the Company,
unless earlier (a) revoked by the undersigned in a signed
writing delivered to such attorney-in-fact or (b)
superseded by a new power of attorney regarding the
purposes outlined in the first paragraph hereof dated as of
a later date.
IN WITNESS WHEREOF, the undersigned has caused this Power of
Attorney to be executed as of January 30, 2013.


Susan D. Wyrick


</TEXT>
</DOCUMENT>
