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Commitments and Contingencies - Additional Information (Detail) | 0 Months Ended | 3 Months Ended | 9 Months Ended |  |  |  | 9 Months Ended | 1 Months Ended | 9 Months Ended
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jul. 02, 2014 USD ($) | Sep. 30, 2014 USD ($) | Sep. 30, 2013 USD ($) | Sep. 30, 2014 USD ($) | Sep. 30, 2013 USD ($) | Sep. 30, 2014 Excess lease facility [Member] USD ($) | Dec. 31, 2013 Excess lease facility [Member] USD ($) | Sep. 30, 2014 Other Long Term Assets [Member] USD ($) | Sep. 30, 2014 Isis Pharmaceuticals Inc. and University of British Columbia [Member] USD ($) | Sep. 30, 2014 Isis Pharmaceuticals Inc. and University of British Columbia [Member] Collaboration arrangement [Member] CAD | Sep. 30, 2014 Isis Pharmaceuticals Inc. [Member] Collaboration arrangement [Member] USD ($) | Dec. 31, 2009 Teva Pharmaceutical Industries Ltd. [Member] Collaboration arrangement [Member] USD ($) | Sep. 30, 2014 Teva Pharmaceutical Industries Ltd. [Member] Collaboration arrangement [Member] USD ($)
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration agreement aggregate amount |  |  |  |  |  |  |  |  |  |  |  | $ 50,000,000 |
Maximum amount receivable |  |  |  |  |  |  |  |  |  |  |  | 370,000,000 |
Equity investment | 24,000,000 |  |  |  |  |  |  |  |  |  |  |  | 10,000,000
Direct and indirect costs incurred |  |  |  |  |  |  |  |  |  |  |  |  | 30,000,000
Milestone payments |  |  |  |  |  |  |  |  |  | 1,600,000 | 7,750,000 |  |
Amount receivable by Isis from TEVA as a milestone payment |  |  |  |  |  |  |  |  |  |  | 30.00% |  |
Percentage of un-spent portion to be paid |  |  |  |  |  |  |  |  |  |  | 30.00% |  |
Obligation to pay patent costs and annual license maintenance fees |  |  |  |  |  |  |  |  |  | 8,000 |  |  |
Milestone payment |  |  |  |  |  |  |  |  |  | 100,000 | 800,000 |  |
Expiry period of agreement of patented license |  |  |  |  |  |  |  |  |  |  | 20 years |  |
Range of each product line |  |  |  |  |  |  |  |  |  |  | 10 years |  |
Milestone payment due |  |  |  |  |  |  |  |  | 20,000,000 |  | 20,000,000 |  |
Period of milestone payment |  |  |  |  |  |  |  |  | 21 days |  | 21 days |  |
Reserve for contingency of non payment of non-royalty milestone amount |  |  |  |  |  |  |  |  | 20,000,000 |  | 20,000,000 |  |
Milestone payment made |  |  |  |  |  |  |  |  | 10,000,000 |  | 10,000,000 |  |
Balance amount of milestone payment |  |  |  |  |  |  |  |  | 10,000,000 |  | 10,000,000 |  |
Expiration of operating lease agreement |  |  |  | 2015-09 |  |  |  |  |  |  |  |  |
Expiration of non-cancellable operating lease agreement |  |  |  | 2017 |  |  |  |  |  |  |  |  |
Cash security deposit |  |  |  |  |  |  |  | 500,000 |  |  |  |  |
Standby letter of credit |  | 300,000 |  | 300,000 |  |  |  |  |  |  |  |  |
Lease liability |  |  |  |  |  | 3,324,000 | 3,906,000 |  |  |  |  |  |
Consolidated rent and facilities expense |  | 700,000 | 700,000 | 2,100,000 | 2,100,000 |  |  |  |  |  |  |  |
Indemnification obligations |  | 0 |  | 0 |  |  |  |  |  |  |  |  |
Expenses related to indemnification issues |  | $ 0 |  | $ 0 |  |  |  |  |  |  |  |  |

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