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Collaboration Agreement - Additional Information (Detail) (USD $) | 0 Months Ended | 3 Months Ended | 9 Months Ended |  | 9 Months Ended | 1 Months Ended | 9 Months Ended | 1 Months Ended | 9 Months Ended | 1 Months Ended
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Jul. 02, 2014 | Sep. 30, 2014 | Sep. 30, 2013 | Sep. 30, 2014 | Sep. 30, 2013 | Dec. 31, 2013 | Sep. 30, 2014 Isis Pharmaceuticals Inc. and University of British Columbia [Member] | Dec. 31, 2009 Collaboration arrangement [Member] Teva Pharmaceutical Industries Ltd. [Member] | Sep. 30, 2014 Collaboration arrangement [Member] Teva Pharmaceutical Industries Ltd. [Member] | Sep. 30, 2014 Collaboration arrangement [Member] Teva Pharmaceutical Industries Ltd. [Member] Minimum [Member] | Sep. 30, 2014 Collaboration arrangement [Member] Teva Pharmaceutical Industries Ltd. [Member] Maximum [Member] | Dec. 31, 2009 Collaboration arrangement [Member] Isis Pharmaceuticals Inc. [Member] | Sep. 30, 2014 Collaboration arrangement [Member] Isis Pharmaceuticals Inc. [Member] | Dec. 31, 2009 Collaboration arrangement [Member] Isis Pharmaceuticals Inc. and University of British Columbia [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration agreement aggregate amount |  |  |  |  |  |  |  | $ 50,000,000 |  |  |  |  |  |
Maximum amount receivable |  |  |  |  |  |  |  | 370,000,000 |  |  |  |  |  |
Equity investment | 24,000,000 |  |  |  |  |  |  |  | 10,000,000 |  |  |  |  |
Royalties at percentage rates ranging |  |  |  |  |  |  |  |  | Mid-teens to mid-twenties on net sales |  |  |  |  |
Share premium |  |  |  |  |  |  |  |  | 20.00% |  |  |  |  |
Common shares, purchase price |  |  |  |  |  |  |  |  | $ 37.38 |  |  |  |  |
Common shares purchased |  |  |  |  |  |  |  |  | 267,531 |  |  |  |  |
Average premium period |  |  |  |  |  |  |  |  | 30 days |  |  |  |  |
Research and development |  | 9,586,000 | 18,004,000 | 36,372,000 | 42,122,000 |  |  |  |  |  |  | 10,000,000 |  | 300,000
Percentage of milestone payments required to be paid to third party |  |  |  |  |  |  |  |  | 31.00% |  |  |  |  |
Percentage of net sales required to be paid as royalty to third party |  |  |  |  |  |  |  |  |  | 4.88% | 8.00% |  |  |
Direct and indirect costs incurred |  |  |  |  |  |  |  |  | 30,000,000 |  |  |  |  |
Required period of notice for termination of collaboration agreement |  |  |  |  |  |  |  |  |  | 3 months | 6 months |  |  |
Expiration of royalties |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |
Period of authorization change |  |  |  |  |  |  |  |  | 90 days |  |  |  |  |
Receivable for unbilled expense reimbursements |  | 4,827,000 |  | 4,827,000 |  | 8,657,000 |  |  |  |  |  |  |  |
Milestone payment due |  |  |  |  |  |  | 20,000,000 |  |  |  |  |  | 20,000,000 |
Period of milestone payment |  |  |  |  |  |  | 21 days |  |  |  |  |  | 21 days |
Reserve for contingency of non payment of non-royalty milestone amount |  |  |  |  |  |  | 20,000,000 |  |  |  |  |  | 20,000,000 |
Milestone payment made |  |  |  |  |  |  | 10,000,000 |  |  |  |  |  | 10,000,000 |
Balance amount of milestone payment |  |  |  |  |  |  | 10,000,000 |  |  |  |  |  | 10,000,000 |
Balance in advanced reimbursement of development activities |  |  |  |  |  |  | $ 30,000,000 |  |  |  |  |  |  |

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