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License Agreements - Additional Information (Detail) |  |  | 1 Months Ended | 18 Months Ended | 108 Months Ended
--- | --- | --- | --- | --- | ---
Jan. 22, 2018 USD ($) | May 14, 2015 | Jul. 31, 2016 USD ($) | Dec. 31, 2017 USD ($) g | Dec. 31, 2017 USD ($)
Sopharma [Member] |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Payments under license agreement |  |  |  |  | $ 10
License agreement expiry date |  | May 26, 2029 |  |  |
University of Bristol [Member] |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Payments under license agreement |  |  |  | $ 50,000 |
Maximum amount payable under license agreement, tied to milestones |  |  | $ 3,200,000 |  |
License agreement expiry |  |  | 2036-07 |  |
Volume of cytisine provided as an initial contribution | g |  |  |  | 100 |
University of Bristol [Member] | Amendment to the University of Bristol License Agreement [Member] | Subsequent Event [Member] |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Payments under license agreement | $ 37,500 |  |  |  |
Maximum amount payable under license agreement, tied to milestones | $ 1,700,000 |  |  |  |
University of Bristol [Member] | Minimum [Member] | License Agreement [Member] |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Patent expiry date |  |  | Feb. 05, 2036 |  |

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