<SEC-DOCUMENT>0001209191-18-046838.txt : 20180815
<SEC-HEADER>0001209191-18-046838.hdr.sgml : 20180815
<ACCEPTANCE-DATETIME>20180815165555
ACCESSION NUMBER:		0001209191-18-046838
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20180813
FILED AS OF DATE:		20180815
DATE AS OF CHANGE:		20180815

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			JACOBS CINDY
		CENTRAL INDEX KEY:			0001229762

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	033-80623
		FILM NUMBER:		181021541

	MAIL ADDRESS:	
		STREET 1:		1522 217TH PLACE SE
		STREET 2:		SUITE 100
		CITY:			BOTHELL
		STATE:			WA
		ZIP:			98021

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ACHIEVE LIFE SCIENCES, INC.
		CENTRAL INDEX KEY:			0000949858
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				954343413
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		520 PIKE STREET
		STREET 2:		SUITE 2250
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98101
		BUSINESS PHONE:		425-686-1500

	MAIL ADDRESS:	
		STREET 1:		520 PIKE STREET
		STREET 2:		SUITE 2250
		CITY:			SEATTLE
		STATE:			WA
		ZIP:			98101

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ONCOGENEX PHARMACEUTICALS, INC.
		DATE OF NAME CHANGE:	20080821

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SONUS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19950825
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2018-08-13</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000949858</issuerCik>
        <issuerName>ACHIEVE LIFE SCIENCES, INC.</issuerName>
        <issuerTradingSymbol>ACHV</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001229762</rptOwnerCik>
            <rptOwnerName>JACOBS CINDY</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>520 PIKE STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 2250</rptOwnerStreet2>
            <rptOwnerCity>SEATTLE</rptOwnerCity>
            <rptOwnerState>WA</rptOwnerState>
            <rptOwnerZipCode>98101</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>EVP, CMO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
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                <value>Common Stock</value>
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            </transactionDate>
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            <transactionTimeliness>
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            <transactionAmounts>
                <transactionShares>
                    <value>1486</value>
                    <footnoteId id="F1"/>
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                <transactionPricePerShare>
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                <transactionAcquiredDisposedCode>
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            <transactionAmounts>
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                    <footnoteId id="F3"/>
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                <transactionPricePerShare>
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                    <footnoteId id="F4"/>
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    </nonDerivativeTable>

    <derivativeTable>
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            <deemedExecutionDate></deemedExecutionDate>
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            <transactionAmounts>
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                    <footnoteId id="F6"/>
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                <transactionPricePerShare>
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                <transactionAcquiredDisposedCode>
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        <derivativeTransaction>
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            <transactionDate>
                <value>2018-08-13</value>
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            <deemedExecutionDate></deemedExecutionDate>
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                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
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                    <value>45</value>
                    <footnoteId id="F9"/>
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                <transactionPricePerShare>
                    <value>0.00</value>
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                <transactionAcquiredDisposedCode>
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                </transactionAcquiredDisposedCode>
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            <exerciseDate>
                <footnoteId id="F10"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F8"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>45</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
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                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>43</value>
                    <footnoteId id="F11"/>
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                <transactionPricePerShare>
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                <transactionAcquiredDisposedCode>
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            </expirationDate>
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            </underlyingSecurity>
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        <derivativeTransaction>
            <securityTitle>
                <value>Restricted Stock Unit (RSU)</value>
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            <transactionDate>
                <value>2018-08-13</value>
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            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>1370</value>
                    <footnoteId id="F13"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
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            <exerciseDate>
                <footnoteId id="F14"/>
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            <expirationDate>
                <value>2021-08-01</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1370</value>
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            </underlyingSecurity>
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                <sharesOwnedFollowingTransaction>
                    <value>4110</value>
                </sharesOwnedFollowingTransaction>
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            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
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        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Represents shares of common stock acquired upon settlement of the restricted stock units (&quot;RSUs&quot;) listed in Table II.</footnote>
        <footnote id="F2">On May 23 2018, the Issuer effected a 1-for-10 split of its common stock (the &quot;Stock Split&quot;) resulting in a decrease of the reporting person's ownership by 7,179 shares of common stock.</footnote>
        <footnote id="F3">Represents shares of common stock that have been sold by the Issuer to satisfy its income tax withholding and remittance obligations in connection with the net settlement of the RSUs and does not represent a sale by the reporting person.</footnote>
        <footnote id="F4">The reported price in Column 4 is a weighted average price.  These shares were sold in multiple transactions at prices ranging from $2.77 to $2.815 per share, inclusive.  The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.</footnote>
        <footnote id="F5">Each RSU represents a contingent right to receive one share of the issuer's common stock at settlement.</footnote>
        <footnote id="F6">This RSU was previously reported as covering 284 shares, which number was adjusted to reflect the Stock Split.</footnote>
        <footnote id="F7">Pursuant to the terms of the RSU, 25% of the total shares underlying the RSU vest annually on the later of (i) each anniversary of January 1, 2014 and (ii) the first day thereafter during which the issuer's trading window is open.</footnote>
        <footnote id="F8">The RSUs expire 30 days from the date they vest.</footnote>
        <footnote id="F9">This RSU was previously reported as covering 454 shares, which number was adjusted to reflect the Stock Split.</footnote>
        <footnote id="F10">Pursuant to the terms of the RSU, 25% of the total shares underlying the RSU vest annually on the later of (i) each anniversary of June 12, 2014 and (ii) the first day thereafter during which the issuer's trading window is open.</footnote>
        <footnote id="F11">This RSU was previously reported as covering 852 shares, which number was adjusted to reflect the Stock Split.</footnote>
        <footnote id="F12">Pursuant to the terms of the RSU, 25% of the total shares underlying the RSU vest annually on the later of (i) each anniversary of January 1, 2015 and (ii) the first day thereafter during which the issuer's trading window is open.</footnote>
        <footnote id="F13">This RSU was previously reported as covering 54,800 shares, which number was adjusted to reflect the Stock Split.</footnote>
        <footnote id="F14">Pursuant to the terms of the RSU, 25% of the total shares underlying the RSU vest annually on the later of (i) each anniversary of August 1, 2017 and (ii) the first day thereafter during which the issuer's trading window is open.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Sandra Thomson as attorney-in-fact for Cindy Jacobs</signatureName>
        <signatureDate>2018-08-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
