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Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended | 31 Months Ended
--- | --- | ---
Mar. 31, 2020 | Mar. 31, 2019 | Mar. 31, 2020
Operating Activities: |  |  |
Net loss | $ (3,320) | $ (5,904) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization [note 3] | 61 | 65 |
Stock-based compensation [note 6 [c] and note 6 [d]] | 302 | 290 |
Changes in operating assets and liabilities: |  |  |
Amounts receivable | 8 |  |
Prepaid expenses and other assets | (190) | 88 |
Accounts payable | (675) | 550 |
Accrued liabilities other | (130) | (199) |
Accrued clinical liabilities | 184 | 887 |
Accrued compensation | (697) | (680) |
Lease obligation [note 7] | (4) | 14 |
Net cash used in operating activities | (4,461) | (4,889) |
Financing Activities: |  |  |
Net cash used in financing activities | (47) |  |
Investing Activities: |  |  |
Purchase of property and equipment | (2) | (54) |
Purchase of investments |  | (20) |
Proceeds from maturities of investments |  | 2,764 |
Net cash provided by (used in) investing activities | (2) | 2,690 |
Effect of exchange rate changes on cash | 2 | 4 |
Net increase (decrease) in cash, cash equivalents and restricted cash | (4,508) | (2,195) |
Cash, cash equivalents and restricted cash at beginning of the period | 16,714 | 9,565 |
Cash, cash equivalents and restricted cash at end of the period | 12,206 | $ 7,370 | $ 12,206
LPC [Member] |  |  |
Financing Activities: |  |  |
Costs relating to registered direct offering and purchase agreement |  |  | $ (500)
LPC [Member] | Purchase Agreement [Member] |  |  |
Financing Activities: |  |  |
Costs relating to registered direct offering and purchase agreement | (13) |  |
December 2019 Registered Direct Offering [Member] |  |  |
Financing Activities: |  |  |
Costs relating to registered direct offering and purchase agreement | $ (34) |  |

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