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Common Stock (Tables) | 12 Months Ended
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Dec. 31, 2020
Equity [Abstract] |
Summary of Fair Value of Option Awards | The estimated fair value of stock options granted in the respective periods was determined using the Black-Scholes option pricing model using the following weighted average assumptions:
|  | 2020 |  |  | 2019 |  |
Risk-free interest rates |  |  | 0.94 | % |  |  | 2.52 | % |
Expected dividend yield |  |  | 0 | % |  |  | 0 | % |
Expected life |  | 6.00 years |  |  | 5.97 years |  |
Expected volatility |  |  | 108.78 | % |  |  | 94.25 | % |
Forfeiture rate |  |  | 0 | % |  |  | 0 | % |
Summary of Share-Based Compensation Expense | The results for the periods set forth below included stock-based compensation expense in the following expense categories of the consolidated statements of loss (in thousands):
|  | Year ended |
|  | December 31, |
|  | 2020 |  |  | 2019 |
Research and development |  | $ | 403 |  |  | $ | 364 |
General and administrative |  |  | 883 |  |  |  | 837 |
Total stock-based compensation |  | $ | 1,286 |  |  | $ | 1,201 |
Summary of Stock Options Activity | Stock option transactions and the number of stock options outstanding are summarized below:
|  | Number of |  |  | Weighted |
|  | Optioned |  |  | Average |
|  | Common |  |  | Exercise |
|  | Shares |  |  | Price |
Balance, January 1, 2020 |  |  | 50,498 |  |  | $ | 190.46 |
Granted |  |  | 178,380 |  |  |  | 10.66 |
Expired |  |  | (30 | ) |  |  | 34,874.40 |
Forfeited |  |  | (1,406 | ) |  |  | 227.61 |
Balance, December 31, 2020 |  |  | 227,442 |  |  | $ | 44.64 |
Summary of Stock Options Outstanding Regarding Number of Common Shares Issuable upon Exercise of Outstanding Options | (1) Number of common shares issuable upon exercise of outstanding options:
|  |  |  |  |  |  |  |  |  | Weighted- |
|  |  |  |  |  |  |  |  |  | Average |
|  |  |  |  |  |  |  |  |  | Remaining |
|  |  |  |  |  | Weighted- |  |  | Contractual |
|  |  |  |  |  | Average |  |  | Life |
Exercise Prices |  | Number of Options |  |  | Exercise Price |  |  | (in years) |
$8.60 -$9.48 |  |  | 5,500 |  |  | $ | 8.60 |  |  |  | 9.36 |
$9.49 - $10.78 |  |  | 98,000 |  |  |  | 10.36 |  |  |  | 9.88 |
$10.79 - $19.80 |  |  | 74,880 |  |  |  | 11.20 |  |  |  | 9.08 |
$19.81 - $39.80 |  |  | 14,766 |  |  |  | 28.40 |  |  |  | 8.08 |
$39.81 - $59.30 |  |  | 18,747 |  |  |  | 51.20 |  |  |  | 7.72 |
$59.31 - $67.50 |  |  | 8,087 |  |  |  | 67.40 |  |  |  | 7.57 |
$67.51 - $329.20 |  |  | 2,162 |  |  |  | 77.96 |  |  |  | 8.35 |
$329.21 - $1,389.00 |  |  | 5,069 |  |  |  | 578.00 |  |  |  | 6.58 |
$1,389.01 - $6,424.00 |  |  | 109 |  |  |  | 3,845.36 |  |  |  | 4.53 |
$6,424.01 - $39,204.00 |  |  | 122 |  |  |  | 23,032.56 |  |  |  | 2.58 |
|  |  | 227,442 |  |  | $ | 44.64 |  |  |  | 9.13 |
Summary of Stock Options Outstanding Regarding Number of Common Shares Issuable upon Exercise of Vested Options | (2) Number common shares issuable upon exercise of vested options:
|  |  |  |  |  |  |  |  |  | Weighted- |
|  |  |  |  |  |  |  |  |  | Average |
|  |  |  |  |  |  |  |  |  | Remaining |
|  |  |  |  |  | Weighted- |  |  | Contractual |
|  |  |  |  |  | Average |  |  | Life |
Exercise Prices |  | Number of Options |  |  | Exercise Price |  |  | (in years) |
$8.60 -$9.48 |  |  | — |  |  | $ | — |  |  |  | — |
$9.49 - $10.78 |  |  | — |  |  |  | — |  |  |  | — |
$10.79 - $19.80 |  |  | — |  |  |  | — |  |  |  | — |
$19.81 - $39.80 |  |  | 8,459 |  |  |  | 28.40 |  |  |  | 8.08 |
$39.81 - $59.30 |  |  | 11,951 |  |  |  | 51.20 |  |  |  | 7.72 |
$59.31 - $67.50 |  |  | 4,930 |  |  |  | 67.40 |  |  |  | 7.57 |
$67.51 - $329.20 |  |  | 1,926 |  |  |  | 79.23 |  |  |  | 8.36 |
$329.21 - $1,389.00 |  |  | 4,317 |  |  |  | 578.00 |  |  |  | 6.58 |
$1,389.01 - $6,424.00 |  |  | 109 |  |  |  | 3,845.36 |  |  |  | 4.53 |
$6,424.01 - $39,204.00 |  |  | 122 |  |  |  | 23,032.56 |  |  |  | 2.58 |
|  |  | 31,814 |  |  | $ | 221.96 |  |  |  | 7.65 |
Summary of Restricted Stock Unit Award Activity | The following table summarizes our restricted stock unit award activity during the year ended December 31, 2020:
|  |  |  |  |  | Weighted |
|  | Number |  |  | Average |
|  | of |  |  | Grant Date |
|  | Shares |  |  | Fair Value |
Balance, January 1, 2020 |  |  | 500 |  |  | $ | 579.85 |
Released |  |  | (236 | ) |  |  | 579.96 |
Forfeited or expired |  |  | (33 | ) |  |  | 578.00 |
Balance, December 31, 2020 |  |  | 231 |  |  | $ | 580.00 |
Summary of Outstanding Warrants | The following is a summary of outstanding warrants to purchase common stock at December 31, 2020:
|  | Total |  |  |  |  |  |  |
|  | Outstanding |  |  | Exercise |  |  |
|  | and |  |  | price per |  |  |
|  | Exercisable |  |  | Share |  |  | Expiration Date
(1) Warrants issued in September 2017 financing |  |  | 411 |  |  | $ | 699.2000 |  |  | March 2023
(2) Warrants issued in June 2018 financing |  |  | 114,100 |  |  | $ | 80.0000 |  |  | June 2023
(3) Warrants issued in October 2018 financing |  |  | 31,215 |  |  | $ | 62.8900 |  |  | October 2023
(4) Warrants issued in May 2019 financing |  |  | 60,000 |  |  | $ | 90.0000 |  |  | May 2025
(5) Warrants issued in December 2019 financing |  |  | 660,050 |  |  | $ | 6.6000 |  |  | December 2024
(6) Warrants issued in April 2020 financing |  |  | 182,461 |  |  | $ | 7.2400 |  |  | April 2025
(7) Warrants issued in April 2020 financing |  |  | 28,125 |  |  | $ | 7.3200 |  |  | April 2025
(8) Warrants issued in April 2020 financing |  |  | 25,270 |  |  | $ | 7.5900 |  |  | April 2025
(9) Pre-Funded Warrants issued in August 2020 financing |  |  | 142,857 |  |  | $ | 0.0010 |  |  | *
(10) Warrants issued in December 2020 financing |  |  | 50,000 |  |  | $ | 8.7500 |  |  | December 2025
Computation of Basic and Diluted Net Loss Attributable to Common Shareholders Per Share | The following table presents the computation of basic and diluted net loss attributable to common stockholders per share (in thousands, except per share and share amounts):
|  | Years ended December 31, |
|  | 2020 |  |  | 2019 |  |  | 2018 |
Numerator |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  | $ | (14,730 | ) |  | $ | (16,395 | ) |  | $ | (12,687 | )
Denominator |  |  |  |  |  |  |  |  |  |  |  |
Weighted average number of common shares outstanding |  |  | 2,718,909 |  |  |  | 412,320 |  |  |  | 175,511 |
Basic and diluted net loss per common share |  | $ | (5.42 | ) |  | $ | (39.76 | ) |  | $ | (72.29 | )

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