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Consolidated Statements of Stockholder's Equity - USD ($) $ in Thousands | Total | December 2019 Public Offering [Member] | April 2020 Private Placement [Member] | July 2020 Registered Direct Offering [Member] | August 2020 Public Offering [Member] | December 2020 Public Offering [Member] | May 2021 Public Offering [Member] | June 2018 Financing Costs [Member] | Lincoln Park Capital Fund L L C | Cumulative Adjustment on Adoption of Lease Standard [Member] | Common stock [Member] | Common stock [Member] Series A Convertible Preferred Stock [Member] | Common stock [Member] Series B Convertible Preferred Stock [Member] | Common stock [Member] December 2019 Public Offering [Member] | Common stock [Member] April 2020 Private Placement [Member] | Common stock [Member] July 2020 Registered Direct Offering [Member] | Common stock [Member] August 2020 Public Offering [Member] | Common stock [Member] December 2020 Public Offering [Member] | Common stock [Member] May 2021 Public Offering [Member] | Common stock [Member] Lincoln Park Capital Fund L L C | Preferred Stock [Member] | Preferred Stock [Member] Series A Convertible Preferred Stock [Member] | Preferred Stock [Member] Series B Convertible Preferred Stock [Member] | Preferred Stock [Member] December 2019 Public Offering [Member] | Additional paid-in capital [Member] | Additional paid-in capital [Member] Series A Convertible Preferred Stock [Member] | Additional paid-in capital [Member] Series B Convertible Preferred Stock [Member] | Additional paid-in capital [Member] December 2019 Public Offering [Member] | Additional paid-in capital [Member] April 2020 Private Placement [Member] | Additional paid-in capital [Member] July 2020 Registered Direct Offering [Member] | Additional paid-in capital [Member] August 2020 Public Offering [Member] | Additional paid-in capital [Member] December 2020 Public Offering [Member] | Additional paid-in capital [Member] May 2021 Public Offering [Member] | Additional paid-in capital [Member] June 2018 Financing Costs [Member] | Additional paid-in capital [Member] Lincoln Park Capital Fund L L C | Accumulated other comprehensive income (loss) [Member] | Accumulated deficit [Member] | Accumulated deficit [Member] Cumulative Adjustment on Adoption of Lease Standard [Member]
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Beginning Balance at Dec. 31, 2017 | $ 15,802 |  |  |  |  |  |  |  |  |  | $ 18 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 41,161 |  |  |  |  |  |  |  |  |  |  | $ 4 | $ (25,381) |
Beginning Balance, Shares at Dec. 31, 2017 |  |  |  |  |  |  |  |  |  |  | 336,055 |  |  |  |  |  |  |  |  |  | 579 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 1,201 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,201 |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted stock unit settlements, Shares |  |  |  |  |  |  |  |  |  |  | 254 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance at Dec. 31, 2018 |  |  |  |  |  |  |  |  |  | $ (3) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (3)
Adjustments to final October 2018 financing costs | 4 |  |  |  |  |  |  | $ 116 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4 |  |  |  |  |  |  |  |  | $ 116 |  |  |  |
Accounting Standards Update [Extensible List] |  |  |  |  |  |  |  |  |  | ASU 2016-02 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued |  | $ 12,334 |  |  |  |  |  |  | $ 792 |  |  |  |  | $ 13 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 12,321 |  |  |  |  |  |  | $ 792 |  |  |
Shares issued, Shares |  |  |  |  |  |  |  |  |  |  |  |  |  | 628,876 |  |  |  |  |  | 18,700 |  |  |  | 6,256 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued on exercise of warrants | 4,199 |  |  |  |  |  |  |  |  |  | $ 1 |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,198 |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued on exercise of warrants, Shares |  |  |  |  |  |  |  |  |  |  | 55,390 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued on conversion of preferred shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 9 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (9) |  |  |  |  |  |  |  |  |  |  |
Shares issued on conversion of preferred shares, Shares |  |  |  |  |  |  |  |  |  |  |  | 7,237 | 427,746 |  |  |  |  |  |  |  |  | (579) | (5,135) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of inducement warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,925 |  |  |  |  |  |  |  |  |  |  |  | (3,925) |
Net loss | (16,395) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (16,395) |
Ending Balance at Dec. 31, 2019 | 18,050 |  |  |  |  |  |  |  |  |  | $ 41 |  |  |  |  |  |  |  |  |  |  |  |  |  | 63,709 |  |  |  |  |  |  |  |  |  |  | 4 | (45,704) |
Ending Balance, Shares at Dec. 31, 2019 |  |  |  |  |  |  |  |  |  |  | 1,474,258 |  |  |  |  |  |  |  |  |  | 1,121 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | $ 1,286 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,286 |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted stock unit settlements, Shares | 236 |  |  |  |  |  |  |  |  |  | 128 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Adjustment of fractional shares on reverse stock split, Shares |  |  |  |  |  |  |  |  |  |  | (9) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued |  |  | $ 1,579 | $ 5,307 | $ 6,822 | $ 15,789 |  |  |  |  |  |  |  |  | $ 6 | $ 15 | $ 1 | $ 2 |  |  |  |  |  |  |  |  |  |  | $ 1,573 | $ 5,292 | $ 6,821 | $ 15,787 |  |  |  |  |  |
Shares issued, Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 280,782 | 731,707 | 569,043 | 2,472,500 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued on exercise of warrants | $ 3,231 |  |  |  |  |  |  |  |  |  | $ 7 |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,224 |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued on exercise of warrants, Shares |  |  |  |  |  |  |  |  |  |  | 489,947 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued on conversion of preferred shares |  |  |  |  |  |  |  |  |  |  |  | $ 2 | $ 2 |  |  |  |  |  |  |  |  |  |  |  |  | $ (2) | $ (2) |  |  |  |  |  |  |  |  |  |  |
Shares issued on conversion of preferred shares, Shares |  |  |  |  |  |  |  |  |  |  |  |  | 93,379 |  |  |  |  |  |  |  |  |  | (1,121) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Costs relating to financing and purchase agreement |  | $ (34) |  |  |  |  |  |  | $ (14) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (34) |  |  |  |  |  |  | $ (14) |  |  |
Net loss | (14,730) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (14,730) |
Ending Balance at Dec. 31, 2020 | 37,286 |  |  |  |  |  |  |  |  |  | $ 76 |  |  |  |  |  |  |  |  |  |  |  |  |  | 97,640 |  |  |  |  |  |  |  |  |  |  | 4 | (60,434) |
Ending Balance, Shares at Dec. 31, 2020 |  |  |  |  |  |  |  |  |  |  | 6,111,735 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 2,187 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,187 |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted stock unit settlements | $ (1) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (1) |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted stock unit settlements, Shares | 231 |  |  |  |  |  |  |  |  |  | 145 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued | $ 41 |  |  |  |  |  | $ 21,343 |  |  |  |  |  |  |  |  |  |  |  | $ 3 |  |  |  |  |  | 41 |  |  |  |  |  |  |  | $ 21,340 |  |  |  |  |
Shares issued, Shares |  |  |  |  |  |  |  |  |  |  | 5,114 |  |  |  |  |  |  |  | 3,285,714 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued on exercise of warrants | 338 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 338 |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued on exercise of warrants, Shares |  |  |  |  |  |  |  |  |  |  | 50,834 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (33,152) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (33,152) |
Ending Balance at Dec. 31, 2021 | $ 28,042 |  |  |  |  |  |  |  |  |  | $ 79 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 121,545 |  |  |  |  |  |  |  |  |  |  | $ 4 | $ (93,586) |
Ending Balance, Shares at Dec. 31, 2021 |  |  |  |  |  |  |  |  |  |  | 9,453,542 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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