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v3.22.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended | 40 Months Ended
--- | --- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2020
Operating Activities: |  |  |  |
Net loss | $ (33,152) | $ (14,730) | $ (16,395) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |
Depreciation | 27 | 32 | 31 |
Amortization [note 5] | 223 | 223 | 223 |
Stock-based compensation [note 12[c]] | 2,187 | 1,286 | 1,201 |
Shares issued as settlement with trade vendor | 41 |  |  |
Cumulative adjustment on adoption of lease standard |  |  | (3) |
Changes in operating assets and liabilities: |  |  |  |
Grant receivable [note 4] | (153) |  |  |
Prepaid expenses and other assets | (228) | (452) | 194 |
Accounts payable | 509 | (527) | 715 |
Accrued liabilities other | (245) | 280 | (328) |
Accrued clinical liabilities | 899 | 66 | (812) |
Accrued compensation | 466 | 358 | (52) |
Lease obligation | (14) | (10) | 10 |
Net cash used in operating activities | (29,440) | (13,474) | (15,216) |
Financing Activities: |  |  |  |
Proceeds from exercise of warrants | 338 | 3,231 | 4,199 |
Receipt of convertible debt from SVB [note 10] | 14,929 |  |  |
Net cash provided by financing activities | 36,610 | 32,680 | 17,325 |
Investing Activities: |  |  |  |
Purchase of property and equipment |  | (17) | (53) |
Purchase of investments |  |  | (25) |
Maturities of investments |  |  | 5,114 |
Net cash provided by (used in) investing activities |  | (17) | 5,036 |
Effect of exchange rate changes on cash | (1) |  | 4 |
Net increase (decrease) in cash, cash equivalents and restricted cash | 7,169 | 19,189 | 7,149 |
Cash, cash equivalents and restricted cash at beginning of year | 35,903 | 16,714 | 9,565 |
Cash, cash equivalents and restricted cash at end of year | 43,072 | 35,903 | 16,714 | $ 35,903
LPC [Member] |  |  |  |
Financing Activities: |  |  |  |
Financing costs relating to purchase agreement with Lincoln Park Capital |  |  |  | $ (500)
LPC [Member] | Purchase Agreement [Member] |  |  |  |
Financing Activities: |  |  |  |
Proceeds from purchase agreement with Lincoln Park Capital, net of issuance costs |  |  | 792 |
Financing costs relating to purchase agreement with Lincoln Park Capital |  | (14) |  |
December 2019 Public Offering [Member] |  |  |  |
Financing Activities: |  |  |  |
Financing costs relating to purchase agreement with Lincoln Park Capital |  | (34) |  |
Proceeds from public offering, net of issuance costs |  |  | $ 12,334 |
April 2020 Private Placement [Member] |  |  |  |
Financing Activities: |  |  |  |
Proceeds from purchase agreement with Lincoln Park Capital, net of issuance costs |  | 1,579 |  |
July 2020 Registered Direct Offering [Member] |  |  |  |
Financing Activities: |  |  |  |
Proceeds from purchase agreement with Lincoln Park Capital, net of issuance costs |  | 5,307 |  |
May 2021 Public Offering [Member] |  |  |  |
Financing Activities: |  |  |  |
Proceeds from offering, net of issuance costs | $ 21,343 |  |  |
August 2020 Public Offering [Member] |  |  |  |
Financing Activities: |  |  |  |
Proceeds from offering, net of issuance costs |  | 6,822 |  |
December 2020 Public Offering [Member] |  |  |  |
Financing Activities: |  |  |  |
Proceeds from offering, net of issuance costs |  | $ 15,789 |  |

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