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Consolidated Statements of Stockholder's Equity - USD ($) $ in Thousands | Total | May 2021 Public Offering [Member] | November 2022 Private Placement [Member] | July 2020 Registered Direct Offering [Member] | August 2020 Public Offering [Member] | December 2020 Public Offering [Member] | December 2019 Public Offering [Member] | Lincoln Park Capital Fund L L C | Common stock [Member] | Common stock [Member] Series A Convertible Preferred Stock [Member] | Common stock [Member] Series B Convertible Preferred Stock [Member] | Common stock [Member] May 2021 Public Offering [Member] | Common stock [Member] November 2022 Private Placement [Member] | Common stock [Member] July 2020 Registered Direct Offering [Member] | Common stock [Member] August 2020 Public Offering [Member] | Common stock [Member] December 2020 Public Offering [Member] | Preferred Stock [Member] | Preferred Stock [Member] Series B Convertible Preferred Stock [Member] | Additional paid-in capital [Member] | Additional paid-in capital [Member] Series A Convertible Preferred Stock [Member] | Additional paid-in capital [Member] Series B Convertible Preferred Stock [Member] | Additional paid-in capital [Member] May 2021 Public Offering [Member] | Additional paid-in capital [Member] November 2022 Private Placement [Member] | Additional paid-in capital [Member] July 2020 Registered Direct Offering [Member] | Additional paid-in capital [Member] August 2020 Public Offering [Member] | Additional paid-in capital [Member] December 2020 Public Offering [Member] | Additional paid-in capital [Member] December 2019 Public Offering [Member] | Additional paid-in capital [Member] Lincoln Park Capital Fund L L C | Accumulated other comprehensive income (loss) [Member] | Accumulated deficit [Member]
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Beginning Balance at Dec. 31, 2019 | $ 18,050 |  |  |  |  |  |  |  | $ 41 |  |  |  |  |  |  |  |  |  | $ 63,709 |  |  |  |  |  |  |  |  |  | $ 4 | $ (45,704)
Beginning Balance, Shares at Dec. 31, 2019 |  |  |  |  |  |  |  |  | 1,474,258 |  |  |  |  |  |  |  | 1,121 |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 1,286 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,286 |  |  |  |  |  |  |  |  |  |  |
Costs relating to financing and purchase agreement |  |  |  |  |  |  | $ (34) | $ (14) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (34) | $ (14) |  |
Shares issued on exercise of warrants | 3,231 |  |  |  |  |  |  |  | $ 7 |  |  |  |  |  |  |  |  |  | 3,224 |  |  |  |  |  |  |  |  |  |  |
Shares issued on exercise of warrants, Shares |  |  |  |  |  |  |  |  | 489,947 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued |  |  | $ 1,579 | $ 5,307 | $ 6,822 | $ 15,789 |  |  |  |  |  |  | $ 6 | $ 15 | $ 1 | $ 2 |  |  |  |  |  |  | $ 1,573 | $ 5,292 | $ 6,821 | $ 15,787 |  |  |  |
Shares issued, Shares |  |  |  |  |  |  |  |  |  |  |  |  | 280,782 | 731,707 | 569,043 | 2,472,500 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted Stock Unit Settlements, Shares |  |  |  |  |  |  |  |  | 128 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued on conversion of preferred shares |  |  |  |  |  |  |  |  |  | $ 2 | $ 2 |  |  |  |  |  |  |  |  | $ (2) | $ (2) |  |  |  |  |  |  |  |  |
Shares issued on conversion of preferred shares, Shares |  |  |  |  |  |  |  |  |  |  | 93,379 |  |  |  |  |  |  | (1,121) |  |  |  |  |  |  |  |  |  |  |  |
Adjustment of fractional shares on reverse stock split |  |  |  |  |  |  |  |  | (9) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (14,730) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (14,730)
Ending Balance at Dec. 31, 2020 | 37,286 |  |  |  |  |  |  |  | $ 76 |  |  |  |  |  |  |  |  |  | 97,640 |  |  |  |  |  |  |  |  |  | 4 | (60,434)
Ending Balance, Shares at Dec. 31, 2020 |  |  |  |  |  |  |  |  | 6,111,735 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 2,187 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,187 |  |  |  |  |  |  |  |  |  |  |
Shares issued on exercise of warrants | 338 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 338 |  |  |  |  |  |  |  |  |  |  |
Shares issued on exercise of warrants, Shares |  |  |  |  |  |  |  |  | 50,834 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued | 41 | $ 21,343 |  |  |  |  |  |  |  |  |  | $ 3 |  |  |  |  |  |  | 41 |  |  | $ 21,340 |  |  |  |  |  |  |  |
Shares issued, Shares |  |  |  |  |  |  |  |  | 5,114 |  |  | 3,285,714 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted stock unit settlements | $ (1) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (1) |  |  |  |  |  |  |  |  |  |  |
Restricted Stock Unit Settlements, Shares | 231 |  |  |  |  |  |  |  | 145 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | $ (33,152) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (33,152)
Ending Balance at Dec. 31, 2021 | 28,042 |  |  |  |  |  |  |  | $ 79 |  |  |  |  |  |  |  |  |  | 121,545 |  |  |  |  |  |  |  |  |  | 4 | (93,586)
Ending Balance, Shares at Dec. 31, 2021 |  |  |  |  |  |  |  |  | 9,453,542 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense | 3,270 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,270 |  |  |  |  |  |  |  |  |  |  |
Shares issued on exercise of warrants | 24 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 24 |  |  |  |  |  |  |  |  |  |  |
Shares issued on exercise of warrants, Shares |  |  |  |  |  |  |  |  | 3,709 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued from purchase agreement with Virtu | 1,330 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,330 |  |  |  |  |  |  |  |  |  |  |
Shares issued from purchase agreement with Virtu, Shares |  |  |  |  |  |  |  |  | 200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued | $ 26 |  | $ 17,882 |  |  |  |  |  |  |  |  |  | $ 8 |  |  |  |  |  | 26 |  |  |  | $ 17,874 |  |  |  |  |  |  |
Shares issued, Shares |  |  |  |  |  |  |  |  | 3,584 |  |  |  | 8,186,282 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted Stock Unit Settlements, Shares | 26,625 |  |  |  |  |  |  |  | 26,625 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Restricted stock unit settlements withheld and retired to treasury | $ (47) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (47) |  |  |  |  |  |  |  |  |  |  |
Restricted stock unit settlements withheld and retired to treasury, Shares |  |  |  |  |  |  |  |  | (5,605) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under employee share purchase plan | 126 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 126 |  |  |  |  |  |  |  |  |  |  |
Shares issued under employee share purchase plan, Shares |  |  |  |  |  |  |  |  | 28,892 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (42,350) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (42,350)
Ending Balance at Dec. 31, 2022 | $ 8,303 |  |  |  |  |  |  |  | $ 87 |  |  |  |  |  |  |  |  |  | $ 144,148 |  |  |  |  |  |  |  |  |  | $ 4 | $ (135,936)
Ending Balance, Shares at Dec. 31, 2022 |  |  |  |  |  |  |  |  | 17,897,029 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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