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Reverse Merger - Summary of Combined Results of Operations of Company and Tokai, on a Pro Forma Basis (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2017 | Jun. 30, 2016 | Jun. 30, 2017 | Jun. 30, 2016
Operating expenses |  |  |  |
Research and development | $ 686 | $ 10,487 | $ 1,471 | $ 19,109
General and administrative | 2,592 | 4,020 | 5,474 | 7,991
Total operating expenses | 3,278 | 14,507 | 6,945 | 27,100
Loss from operations | (3,278) | (14,507) | (6,945) | (27,100)
Other income, net | 18 | (21) | 55 | 42
Net loss and comprehensive loss | $ (3,260) | $ (14,528) | $ (6,890) | $ (27,058)
Net loss per share, basic and diluted | $ (0.47) | $ (2.20) | $ (0.99) | $ (4.10)
Weighted-average shares outstanding, basic and diluted | 6,943,831 | 6,605,009 | 6,943,831 | 6,605,009

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