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Commitments and Contingencies - Additional Information (Detail)
 1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Mar. 31, 2019
USD ($)
Dec. 31, 2015
USD ($)
Sep. 30, 2020
USD ($)
Sep. 30, 2019
USD ($)
Sep. 30, 2020
USD ($)
ft²
OfficeSpace
Milestone
Sep. 30, 2019
USD ($)
Dec. 31, 2019
Milestone
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Other Commitments [Line Items]                  
Rental expense     $ 50,000 $ 47,000 $ 143,000 $ 142,000      
Debt outstanding     0   0        
Future payment under short term remainder of 2020     16,000   16,000        
Future payment under short term 2021     33,000   $ 33,000        
Number of Milestones Achieved | Milestone         0        
Milestone payment $ 300,000                
Indemnification obligations amount     0   $ 0        
Contingent liabilities     0   $ 0        
License Agreement [Member]                  
Other Commitments [Line Items]                  
Sales based milestone payment   $ 36,000,000              
Royalty payment period   8 years              
Office of Chief Scientist of Israeli Ministry of Economy and Industry [Member]                  
Other Commitments [Line Items]                  
Grants received   $ 537,000              
ALS Therapy Development Foundation, Inc. License Agreement [Member]                  
Other Commitments [Line Items]                  
Fee due for milestones achieved               $ 1,000,000 $ 1,000,000
Common stock issued in lieu of making a cash payment               $ 1,000,000 $ 1,000,000
Number of Milestones Achieved | Milestone         0   0    
Remaining milestone payments for first licensed product     6,000,000   $ 6,000,000        
Annual License Maintenance Fee         $ 100,000        
Percentage of royalty aggregate net sales         4.00%        
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 500 Million Aggregate Sales [Member]                  
Other Commitments [Line Items]                  
Reaching of aggregate net sales         $ 500,000,000        
Amount of one-time milestone payment     15,000,000   15,000,000        
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 1 Billion Aggregate Sales [Member]                  
Other Commitments [Line Items]                  
Reaching of aggregate net sales         1,000,000,000        
Amount of one-time milestone payment     30,000,000   $ 30,000,000        
Maximum [Member]                  
Other Commitments [Line Items]                  
Remaining term of office lease         1 year        
Maximum [Member] | License Agreement [Member]                  
Other Commitments [Line Items]                  
Development and regulatory milestone payments   42,100,000              
Maximum [Member] | ALS Therapy Development Foundation, Inc. License Agreement [Member]                  
Other Commitments [Line Items]                  
Development and regulatory milestone payments     $ 2,500,000   $ 2,500,000        
Minimum [Member]                  
Other Commitments [Line Items]                  
Remaining term of office lease         9 months        
Minimum [Member] | License Agreement [Member]                  
Other Commitments [Line Items]                  
Sales required to achieve milestone payment   $ 1,000,000,000              
Irvine, California                  
Other Commitments [Line Items]                  
Area of office space | ft²         5,197        
Lease expiration date         Sep. 30, 2021        
Burlington, Massachusetts                  
Other Commitments [Line Items]                  
Lease expiration date         Jun. 30, 2021        
Number of office spaces operating lease | OfficeSpace         4