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Commitments and Contingencies - Additional Information (Detail) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2019 USD ($) | Dec. 31, 2015 USD ($) | Nov. 30, 2015 USD ($) shares | Dec. 31, 2020 USD ($) ft² OfficeSpace Milestone | Dec. 31, 2019 USD ($) Milestone | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($)
Other Commitments [Line Items] |  |  |  |  |  |  |
Rental expense |  |  |  | $ 207,000 | $ 188,000 |  |
Debt outstanding |  |  |  | 0 |  |  |
Future payment under short term 2021 |  |  |  | $ 33,000 |  |  |
Number of Milestones Achieved | Milestone |  |  |  | 0 | 0 |  |
Indemnification obligations amount |  |  |  | $ 0 |  |  |
Contingent liabilities |  |  |  | $ 0 | $ 0 |  |
Research and Development Expenses [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Milestone payment | $ 300,000 |  |  |  |  |  |
License Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Sales based milestone payment |  | $ 36,000,000 |  |  |  |  |
Royalty payment period |  | 8 years |  |  |  |  |
Office of Chief Scientist of Israeli Ministry of Economy and Industry [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Grants received |  | $ 537,000 |  |  |  |  |
Scientific Development and Research, Inc. and Otodyne, Inc. [Member] | License Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
License fees paid |  |  | $ 750,000 |  |  |  |
Common stock, number of shares sold | shares |  |  | 9,780 |  |  |  |
ALS Therapy Development Foundation, Inc. License Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Fee due for milestones achieved |  |  |  |  |  | $ 1,000,000 | $ 1,000,000
Common stock issued in lieu of making a cash payment |  |  |  |  |  | $ 1,000,000 | $ 1,000,000
Number of Milestones Achieved | Milestone |  |  |  | 0 | 0 |  |
Remaining milestone payments for first licensed product |  |  |  | $ 6,000,000 |  |  |
Annual License Maintenance Fee |  |  |  | 100,000 |  |  |
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 500 Million Aggregate Sales [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Reaching of aggregate net sales |  |  |  | 500,000,000 |  |  |
Amount of one-time milestone payment |  |  |  | 15,000,000 |  |  |
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 1 Billion Aggregate Sales [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Reaching of aggregate net sales |  |  |  | 1,000,000,000 |  |  |
Amount of one-time milestone payment |  |  |  | $ 30,000,000 |  |  |
Minimum [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Remaining term of office lease |  |  |  | 9 months |  |  |
Minimum [Member] | License Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Sales required to achieve milestone payment |  | 1,000,000,000 |  |  |  |  |
Maximum [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Remaining term of office lease |  |  |  | 1 year |  |  |
Maximum [Member] | License Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Development and regulatory milestone payments |  | $ 42,100,000 |  |  |  |  |
Maximum [Member] | ALS Therapy Development Foundation, Inc. License Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Development and regulatory milestone payments |  |  |  | $ 2,500,000 |  |  |
Irvine, California |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Area of office space | ft² |  |  |  | 5,197 |  |  |
Lease expiration date |  |  |  | Sep. 30, 2021 |  |  |
Burlington, Massachusetts |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Lease expiration date |  |  |  | Jun. 30, 2021 |  |  |
Number of office spaces operating lease | OfficeSpace |  |  |  | 4 |  |  |

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