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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2020
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] |
Summary of Stock Option Activity | The following table shows the stock option activity, as follows:
|  | Shares Issuable Under Options |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term |  |  | Aggregate Intrinsic Value |
|  |  |  |  |  |  |  |  |  | (In years) |  |  |  |  |
Outstanding as of January 1, 2019 |  |  | 49,798 |  |  | $ | 233.45 |  |  |  | 8.1 |  |  | $ | — |
Granted |  |  | 42,244 |  |  |  | 28.87 |  |  |  |  |  |  |  |  |
Exercised |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Forfeited / Canceled |  |  | (639 | ) |  |  | 79.38 |  |  |  |  |  |  |  |  |
Outstanding as of December 31, 2019 |  |  | 91,403 |  |  |  | 139.96 |  |  |  | 8.2 |  |  |  | — |
Granted |  |  | 2,191,462 |  |  |  | 9.15 |  |  |  |  |  |  |  |  |
Options assumed in connection with acquisition |  |  | 1,346,398 |  |  |  | 7.58 |  |  |  |  |  |  |  |  |
Exercised |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Forfeited / Canceled |  |  | (7,784 | ) |  |  | 586.16 |  |  |  |  |  |  |  |  |
Outstanding as of December 31, 2020 |  |  | 3,621,479 |  |  | $ | 10.63 |  |  |  | 8.9 |  |  | $ | 23,938,701 |
Options vested and expected to vest as of December 31, 2020 |  |  | 3,621,479 |  |  | $ | 15.21 |  |  |  | 8.9 |  |  | $ | 23,938,701 |
Options exercisable as of December 31, 2020 |  |  | 878,033 |  |  | $ | 16.00 |  |  |  | 8.2 |  |  | $ | 6,297,510 |
Summary of PRSU Activity | The following table shows the PRSU activity, as follows:
|  | Shares Issuable Under PRSUs |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term |  |  | Aggregate Intrinsic Value |
|  |  |  |  |  |  |  |  |  | (In years) |  |  |  |  |
Outstanding as of January 1, 2019 |  |  | 4,358 |  |  | $ | 86.94 |  |  |  | 9.2 |  |  | $ | — |
Granted |  |  | 3,056 |  |  |  | 66.96 |  |  |  |  |  |  |  |  |
PRSUs Vested |  |  | (4,358 | ) |  |  | 86.94 |  |  |  |  |  |  |  |  |
Forfeited / Canceled |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Outstanding as of December 31, 2019 |  |  | 3,056 |  |  |  | 66.96 |  |  |  | 9.2 |  |  |  | — |
Granted |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
PRSUs Vested |  |  | (3,056 | ) |  |  | 66.96 |  |  |  |  |  |  |  |  |
Forfeited / Canceled |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Outstanding as of December 31, 2020 |  |  | — |  |  | $ | — |  |  |  |  |  |  | $ | — |
PRSUs vested and expected to vest as of December 31, 2020 |  |  | — |  |  | $ | — |  |  |  |  |  |  | $ | — |
Options exercisable as of December 31, 2020 |  |  | — |  |  | $ | — |  |  |  |  |  |  | $ | — |
Schedule of Stock-Based Compensation Expense Related to Stock-Based Awards | Total compensation expense related to all of the Company’s stock-based awards for the years ended December 31, 2020 and 2019 was comprised of the following (in thousands):
|  | Year Ended December 31, |
|  | 2020 |  |  | 2019 |
Stock-based compensation classified as: |  |  |  |  |  |  |  |
Research and development expense |  | $ | 1,254 |  |  | $ | 343 |
General and administrative expense |  |  | 1,917 |  |  |  | 965 |
Total stock-based compensation expense |  | $ | 3,171 |  |  | $ | 1,308 |
Schedule of Assumptions Used in Black-Scholes Option Pricing Model to Determine the Fair Value of Stock Options Granted | The following table presents the assumptions used in the Black-Scholes option pricing model to determine the fair value of stock options granted in the periods presented, as follows:
|  | Year Ended December 31, |
|  | 2020 |  |  | 2019 |
Expected stock price volatility |  | 77% - 107% |  |  | 74% - 87% |
Risk-free interest rate |  | 0% - 1% |  |  | 1% - 3% |
Expected life of option (in years) |  | 4 - 6 |  |  | 6 |
Estimated dividend yield |  | 0% |  |  | 0% |

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