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Stockholders' Equity - Additional Information (Detail) |  |  |  |  |  |  |  | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Dec. 23, 2020 USD ($) shares | Dec. 18, 2020 $ / shares shares | Sep. 14, 2020 USD ($) shares | Jun. 10, 2020 shares | Feb. 13, 2020 USD ($) Feature $ / shares shares | Jan. 15, 2020 USD ($) $ / shares shares | Apr. 30, 2019 USD ($) $ / shares shares | Dec. 31, 2020 USD ($) $ / shares shares | Dec. 31, 2019 USD ($) $ / shares shares | Feb. 19, 2020 shares | Jul. 23, 2018 USD ($)
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Proceeds from issuance of common stock | $ |  |  |  |  |  |  |  | $ 9,000,000 | $ 9,676,000 |  |
Warrant inducement expense | $ |  |  |  |  |  |  |  | $ 4,829,000 |  |  |
Number of shares exercised |  |  |  |  |  |  |  | 457,390 |  |  |
Warrants available for exercise |  |  |  |  |  |  |  | 337,822 | 392,815 |  |
Issuance of common stock in connection with conversion of Series X preferred stock, Shares |  |  |  |  |  |  |  | (3,796) |  |  |
Proceeds from issuance of non-voting preferred stock in connection with PIPE transaction, net | $ |  |  |  |  |  |  |  | $ 95,226,000 |  |  |
Common stock, shares outstanding |  |  |  |  |  |  |  | 15,160,397 | 720,408 |  |
Anelixis [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares exercised |  |  |  |  |  |  |  | 0 |  |  |
Warrants available for exercise |  |  |  |  |  |  |  | 55,583.875 | 0 |  |
Assumed and replaced |  |  |  |  |  |  |  | 55,583.875 |  |  |
Anelixis [Member] | Stock Options [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Estimated fair value, assumed and replaced value | $ |  |  | $ 2,950,000 |  |  |  |  |  |  |  |
Series A Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares exercised |  |  |  |  |  |  |  | 191,617 |  |  |
Warrants available for exercise |  |  |  |  |  |  |  | 0 | 191,617 |  |
Series B Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares exercised |  |  |  |  |  |  |  | 191,617 |  |  |
Warrants available for exercise |  |  |  |  |  |  |  | 0 | 191,617 |  |
Series X1 Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrants available for exercise |  |  |  |  |  |  |  | 55,853.875 |  |  |
Preferred stock, par value | $ / shares |  | $ 0.001 |  |  |  |  |  |  |  |  |
Series X1 Preferred Stock [Member] | Anelixis [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock |  |  | 140,026 |  |  |  |  |  |  |  |
Series X1 Preferred Stock [Member] | Anelixis [Member] | Stock Options [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Estimated fair value, assumed and replaced |  |  | 1,346,398 |  |  |  |  |  |  |  |
Estimated fair value, assumed and replaced value | $ |  |  | $ 6,000,000 |  |  |  |  |  |  |  |
Series X Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Preferred stock, par value | $ / shares |  | $ 0.001 |  |  |  |  |  | $ 0.001 | $ 0.001 |  |
Conversion of stock, shares converted |  |  |  | 3,285 |  |  |  |  |  |  |
Number of embedded features within preferred stock | Feature |  |  |  |  | 2 |  |  |  |  |  |
Number of common stock, shares issued upon conversion |  | 511 |  |  |  |  |  |  |  |  |
Preferred shares outstanding |  |  |  |  |  |  |  | 0 | 0 |  |
Securities Purchase Agreement [Member] | 2019 Equity Offering [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Common stock shares agreed to sell |  |  |  |  |  |  | 191,617 |  |  |  |
Common stock shares agreed to sell, gross proceeds value | $ |  |  |  |  |  |  | $ 10,700,000 |  |  |  |
Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares exercised |  |  |  |  |  |  |  | 64,171 |  |  |
Warrants available for exercise |  |  |  |  |  |  |  | 319,064 | 0 |  |
Private Placement [Member] | Series A Warrants [Member] | 2019 Equity Offering [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price per share | $ / shares |  |  |  |  |  |  | $ 72.00 |  |  |  |
Warrants exercisable term |  |  |  |  |  |  | 18 months |  |  |  |
Private Placement [Member] | Series B Warrants [Member] | 2019 Equity Offering [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price per share | $ / shares |  |  |  |  |  |  | $ 72.00 |  |  |  |
Warrants exercisable term |  |  |  |  |  |  | 5 years |  |  |  |
Placement Agent [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares exercised |  |  |  |  |  |  |  | 0 |  |  |
Warrants available for exercise |  |  |  |  |  |  |  | 9,581 | 9,581 |  |
Placement Agent [Member] | 2019 Equity Offering [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price per share | $ / shares |  |  |  |  |  |  | $ 69.66 |  |  |  |
Percentage of warrants to issue shares of common stock |  |  |  |  |  |  | 5.00% |  |  |  |
Warrants offering price maturity date |  |  |  |  |  |  | Apr. 30, 2024 |  |  |  |
Warrant [Member] | Anelixis [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Estimated fair value, assumed and replaced value | $ |  |  | $ 12,944,000 |  |  |  |  |  |  |  |
Warrant [Member] | Series X1 Preferred Stock [Member] | Anelixis [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Assumed and replaced |  |  | 55,583.875 |  |  |  |  |  |  |  |
Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Common stock number of shares issued | 1,004,111 |  |  |  |  |  |  | 1,004,111 |  |  |
Proceeds from issuance of common stock | $ | $ 9,000,000 |  |  |  |  |  |  |  |  |  |
Issuance of common stock in connection with exercise of warrants, net of issuance costs, Shares |  |  |  |  |  |  |  | 421,772 |  |  |
Warrants available for exercise |  |  |  |  |  |  |  | 337,822 |  |  |
Issuance of common stock in connection with conversion of Series X preferred stock, Shares |  |  |  |  |  |  |  | 210,888 |  |  |
Common Stock [Member] | Anelixis [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock |  |  | 175,488 |  |  |  |  |  |  |  |
Shares of common stock issued upon conversion of each share of preferred stock |  |  | 55.5556 |  |  |  |  |  |  |  |
Common Stock [Member] | Series X Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock in connection with conversion of Series X preferred stock, Shares |  |  |  | 182,500 |  |  |  |  |  |  |
Common Stock [Member] | Private Placement [Member] | Series A Warrants [Member] | Maximum [Member] | 2019 Equity Offering [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrants to issue shares of common stock |  |  |  |  |  |  | 191,617 |  |  |  |
Common Stock [Member] | Private Placement [Member] | Series B Warrants [Member] | Maximum [Member] | 2019 Equity Offering [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrants to issue shares of common stock |  |  |  |  |  |  | 191,617 |  |  |  |
Common Stock [Member] | Placement Agent [Member] | Maximum [Member] | 2019 Equity Offering [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrants to issue shares of common stock |  |  |  |  |  |  | 9,580 |  |  |  |
Warrant Exercise Agreements [Member] | Warrants [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Common stock shares agreed to sell, gross proceeds value | $ |  |  |  |  |  | $ 5,800,000 |  |  |  |  |
Warrants to issue shares of common stock |  |  |  |  |  | 383,234 |  |  |  |  |
Warrant reduced exercise price per share | $ / shares |  |  |  |  |  | $ 12.87 |  |  |  |  |
Warrant additional exercise price per share | $ / shares |  |  |  |  |  | 2.25 |  |  |  |  |
Warrant Exercise Agreements [Member] | Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Common stock shares agreed to sell, gross proceeds value | $ |  |  |  |  |  |  |  | $ 188,773 |  |  |
Warrants to issue shares of common stock |  |  |  |  |  |  |  | 64,171 |  |  |
Warrant exercise price per share | $ / shares |  |  |  |  |  | $ 12.96 |  |  |  |  |
Warrants exercisable term |  |  |  |  |  | 5 years 6 months |  |  |  |  |
Issuance of common stock in connection with exercise of warrants, net of issuance costs, Shares |  |  |  |  |  |  |  | 28,553 |  |  |
Number of shares exercised |  |  |  |  |  |  |  | 9,985 |  |  |
Warrant Exercise Agreements [Member] | Common Stock [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrants to issue shares of common stock |  |  |  |  |  | 383,235 |  |  |  |  |
Warrant Exercise Agreements [Member] | Common Stock [Member] | Placement Agent [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price per share | $ / shares |  |  |  |  |  | $ 18.90 |  |  |  |  |
Percentage of warrants to issue shares of common stock |  |  |  |  |  | 5.00% |  |  |  |  |
Warrant Exercise Agreements [Member] | Common Stock [Member] | Placement Agent [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrants to issue shares of common stock |  |  |  |  |  | 19,162 |  |  |  |  |
Stock Purchase Agreement [Member] | Series X1 Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Common stock number of shares issued | 1,004,111 |  |  |  |  |  |  |  |  |  |
Proceeds from issuance of common stock | $ | $ 9,000,000 |  |  |  |  |  |  |  |  |  |
Preferred stock, par value | $ / shares |  | $ 0.001 |  |  |  |  |  |  |  |  |
Conversion of stock, shares converted |  | 231,068 |  |  |  |  |  |  |  |  |
Preferred shares outstanding |  |  |  |  |  |  |  | 108,070 |  |  |
Issuance of preferred stock |  |  | 199,112 |  |  |  |  |  |  |  |
Preferred stock shares aggregate purchase price |  |  | 99,100,000 |  |  |  |  |  |  |  |
Proceeds from issuance of non-voting preferred stock in connection with PIPE transaction, net | $ |  |  | $ 95,200,000 |  |  |  |  |  |  |  |
Business combination additional commitments in equity financing | $ |  |  | $ 9,000,000 |  |  |  |  |  |  |  |
Stock Purchase Agreement [Member] | Common Stock [Member] | Series X1 Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Shares of common stock issued upon conversion of each share of preferred stock |  |  | 55.5556 |  |  |  |  |  |  |  |
Issuance of common stock in connection with conversion of Series X preferred stock, Shares |  | 12,837,056 |  |  |  |  |  |  |  |  |
Stock Purchase Agreement [Member] | Common Stock [Member] | Series X Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Shares of common stock issued upon conversion of each share of preferred stock |  |  | 55.5556 |  |  |  |  |  |  |  |
Warrant Exchange Agreement and Exchange Agreements [Member] | Series X Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Preferred shares outstanding |  |  |  |  |  |  |  | 6,203.98 |  |  |
Warrant Exchange Agreement and Exchange Agreements [Member] | Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Common stock, shares outstanding |  |  |  |  |  |  |  | 14,306,614 |  |  |
Warrant Exchange Agreement and Exchange Agreements [Member] | Common Stock [Member] | Series X Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Shares of common stock issued upon conversion of each share of preferred stock |  |  |  |  |  |  |  | 344,663 |  |  |
Piper Jaffray & Co. [Member] | Equity Distribution Agreement [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Equity distribution agreement maximum value of common shares issuable | $ |  |  |  |  |  |  |  |  |  |  | $ 9,800,000
Common stock number of shares issued |  |  |  |  |  |  |  | 0 |  |  |
Piper Jaffray & Co. [Member] | Equity Distribution Agreement [Member] | Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Common stock number of shares issued |  |  |  |  |  |  |  |  | 1,401 |  |
Proceeds from issuance of common stock | $ |  |  |  |  |  |  |  |  | $ 110,000 |  |
Exchanging Stockholders [Member] | Exchange Agreement [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Reimbursement of expenses | $ |  |  |  |  | $ 25,000 |  |  |  |  |  |
Conversion of stock blocker provision percentage |  |  |  |  | 9.99% |  |  |  |  |  |
Exchanging Stockholders [Member] | Exchange Agreement [Member] | Series X Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Preferred stock, par value | $ / shares |  |  |  |  | $ 0.001 |  |  |  |  |  |
Conversion of stock, shares issued |  |  |  |  | 3,796 |  |  |  |  |  |
Number of designated preferred stock shares |  |  |  |  | 10,000 |  |  |  |  |  |
Exchanging Stockholders [Member] | Exchange Agreement [Member] | Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Conversion of stock, shares converted |  |  |  |  | 210,888 |  |  |  |  |  |
Shares of common stock issued upon conversion of each share of preferred stock |  |  |  |  | 55.5556 |  |  |  |  | 55.5556 |
BVF Exchanging Stockholders, Series X Exchanging Stockholders [Member] | Series X Exchange Agreement [Member] | Series X Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Conversion of stock, shares issued |  |  |  |  |  |  |  | 6,203.98 |  |  |
BVF Exchanging Stockholders, Series X Exchanging Stockholders [Member] | Series X Exchange Agreement [Member] | Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Conversion of stock, shares converted |  |  |  |  |  |  |  | 344,666 |  |  |
BVF Exchanging Stockholders | Warrant Exchange Agreement and Exchange Agreements [Member] | Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |
Warrants to issue shares of common stock |  |  |  |  |  |  |  | 509,117 |  |  |

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