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Commitments and Contingencies - Additional Information (Detail)	1 Months Ended			12 Months Ended
	Mar. 31, 2019 USD ($)	Dec. 31, 2015 USD ($)	Nov. 30, 2015 USD ($) shares	Dec. 31, 2020 USD ($) ft² OfficeSpace Milestone	Dec. 31, 2019 USD ($) Milestone	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)
Other Commitments [Line Items]
Rental expense				$ 207,000	$ 188,000
Debt outstanding				0
Future payment under short term 2021				$ 33,000
Number of Milestones Achieved | Milestone				0	0
Indemnification obligations amount				$ 0
Contingent liabilities				$ 0	$ 0
Research and Development Expenses [Member]
Other Commitments [Line Items]
Milestone payment	$ 300,000
License Agreement [Member]
Other Commitments [Line Items]
Sales based milestone payment		$ 36,000,000
Royalty payment period		8 years
Office of Chief Scientist of Israeli Ministry of Economy and Industry [Member]
Other Commitments [Line Items]
Grants received		$ 537,000
Scientific Development and Research, Inc. and Otodyne, Inc. [Member] | License Agreement [Member]
Other Commitments [Line Items]
License fees paid			$ 750,000
Common stock, number of shares sold | shares			9,780
ALS Therapy Development Foundation, Inc. License Agreement [Member]
Other Commitments [Line Items]
Fee due for milestones achieved						$ 1,000,000	$ 1,000,000
Common stock issued in lieu of making a cash payment						$ 1,000,000	$ 1,000,000
Number of Milestones Achieved | Milestone				0	0
Remaining milestone payments for first licensed product				$ 6,000,000
Annual License Maintenance Fee				100,000
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 500 Million Aggregate Sales [Member]
Other Commitments [Line Items]
Reaching of aggregate net sales				500,000,000
Amount of one-time milestone payment				15,000,000
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 1 Billion Aggregate Sales [Member]
Other Commitments [Line Items]
Reaching of aggregate net sales				1,000,000,000
Amount of one-time milestone payment				$ 30,000,000
Minimum [Member]
Other Commitments [Line Items]
Remaining term of office lease				9 months
Minimum [Member] | License Agreement [Member]
Other Commitments [Line Items]
Sales required to achieve milestone payment		1,000,000,000
Maximum [Member]
Other Commitments [Line Items]
Remaining term of office lease				1 year
Maximum [Member] | License Agreement [Member]
Other Commitments [Line Items]
Development and regulatory milestone payments		$ 42,100,000
Maximum [Member] | ALS Therapy Development Foundation, Inc. License Agreement [Member]
Other Commitments [Line Items]
Development and regulatory milestone payments				$ 2,500,000
Irvine, California
Other Commitments [Line Items]
Area of office space | ft²				5,197
Lease expiration date				Sep. 30, 2021
Burlington, Massachusetts
Other Commitments [Line Items]
Lease expiration date				Jun. 30, 2021
Number of office spaces operating lease | OfficeSpace				4

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