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Stockholders' Equity - Additional Information (Detail)
 12 Months Ended
Dec. 23, 2020
USD ($)
shares
Dec. 18, 2020
$ / shares
shares
Sep. 14, 2020
USD ($)
shares
Jun. 10, 2020
shares
Feb. 13, 2020
USD ($)
Feature
$ / shares
shares
Jan. 15, 2020
USD ($)
$ / shares
shares
Apr. 30, 2019
USD ($)
$ / shares
shares
Dec. 31, 2020
USD ($)
$ / shares
shares
Dec. 31, 2019
USD ($)
$ / shares
shares
Feb. 19, 2020
shares
Jul. 23, 2018
USD ($)
Class Of Stock [Line Items]                      
Proceeds from issuance of common stock | $               $ 9,000,000 $ 9,676,000    
Warrant inducement expense | $               $ 4,829,000      
Number of shares exercised               457,390      
Warrants available for exercise               337,822 392,815    
Issuance of common stock in connection with conversion of Series X preferred stock, Shares               (3,796)      
Proceeds from issuance of non-voting preferred stock in connection with PIPE transaction, net | $               $ 95,226,000      
Common stock, shares outstanding               15,160,397 720,408    
Anelixis [Member]                      
Class Of Stock [Line Items]                      
Number of shares exercised               0      
Warrants available for exercise               55,583.875 0    
Assumed and replaced               55,583.875      
Anelixis [Member] | Stock Options [Member]                      
Class Of Stock [Line Items]                      
Estimated fair value, assumed and replaced value | $     $ 2,950,000                
Series A Warrants [Member]                      
Class Of Stock [Line Items]                      
Number of shares exercised               191,617      
Warrants available for exercise               0 191,617    
Series B Warrants [Member]                      
Class Of Stock [Line Items]                      
Number of shares exercised               191,617      
Warrants available for exercise               0 191,617    
Series X1 Preferred Stock [Member]                      
Class Of Stock [Line Items]                      
Warrants available for exercise               55,853.875      
Preferred stock, par value | $ / shares   $ 0.001                  
Series X1 Preferred Stock [Member] | Anelixis [Member]                      
Class Of Stock [Line Items]                      
Issuance of common stock     140,026                
Series X1 Preferred Stock [Member] | Anelixis [Member] | Stock Options [Member]                      
Class Of Stock [Line Items]                      
Estimated fair value, assumed and replaced     1,346,398                
Estimated fair value, assumed and replaced value | $     $ 6,000,000                
Series X Preferred Stock [Member]                      
Class Of Stock [Line Items]                      
Preferred stock, par value | $ / shares   $ 0.001           $ 0.001 $ 0.001    
Conversion of stock, shares converted       3,285              
Number of embedded features within preferred stock | Feature         2            
Number of common stock, shares issued upon conversion   511                  
Preferred shares outstanding               0 0    
Securities Purchase Agreement [Member] | 2019 Equity Offering [Member]                      
Class Of Stock [Line Items]                      
Common stock shares agreed to sell             191,617        
Common stock shares agreed to sell, gross proceeds value | $             $ 10,700,000        
Private Placement [Member]                      
Class Of Stock [Line Items]                      
Number of shares exercised               64,171      
Warrants available for exercise               319,064 0    
Private Placement [Member] | Series A Warrants [Member] | 2019 Equity Offering [Member]                      
Class Of Stock [Line Items]                      
Warrant exercise price per share | $ / shares             $ 72.00        
Warrants exercisable term             18 months        
Private Placement [Member] | Series B Warrants [Member] | 2019 Equity Offering [Member]                      
Class Of Stock [Line Items]                      
Warrant exercise price per share | $ / shares             $ 72.00        
Warrants exercisable term             5 years        
Placement Agent [Member]                      
Class Of Stock [Line Items]                      
Number of shares exercised               0      
Warrants available for exercise               9,581 9,581    
Placement Agent [Member] | 2019 Equity Offering [Member]                      
Class Of Stock [Line Items]                      
Warrant exercise price per share | $ / shares             $ 69.66        
Percentage of warrants to issue shares of common stock             5.00%        
Warrants offering price maturity date             Apr. 30, 2024        
Warrant [Member] | Anelixis [Member]                      
Class Of Stock [Line Items]                      
Estimated fair value, assumed and replaced value | $     $ 12,944,000                
Warrant [Member] | Series X1 Preferred Stock [Member] | Anelixis [Member]                      
Class Of Stock [Line Items]                      
Assumed and replaced     55,583.875                
Common Stock [Member]                      
Class Of Stock [Line Items]                      
Common stock number of shares issued 1,004,111             1,004,111      
Proceeds from issuance of common stock | $ $ 9,000,000                    
Issuance of common stock in connection with exercise of warrants, net of issuance costs, Shares               421,772      
Warrants available for exercise               337,822      
Issuance of common stock in connection with conversion of Series X preferred stock, Shares               210,888      
Common Stock [Member] | Anelixis [Member]                      
Class Of Stock [Line Items]                      
Issuance of common stock     175,488                
Shares of common stock issued upon conversion of each share of preferred stock     55.5556                
Common Stock [Member] | Series X Preferred Stock [Member]                      
Class Of Stock [Line Items]                      
Issuance of common stock in connection with conversion of Series X preferred stock, Shares       182,500              
Common Stock [Member] | Private Placement [Member] | Series A Warrants [Member] | Maximum [Member] | 2019 Equity Offering [Member]                      
Class Of Stock [Line Items]                      
Warrants to issue shares of common stock             191,617        
Common Stock [Member] | Private Placement [Member] | Series B Warrants [Member] | Maximum [Member] | 2019 Equity Offering [Member]                      
Class Of Stock [Line Items]                      
Warrants to issue shares of common stock             191,617        
Common Stock [Member] | Placement Agent [Member] | Maximum [Member] | 2019 Equity Offering [Member]                      
Class Of Stock [Line Items]                      
Warrants to issue shares of common stock             9,580        
Warrant Exercise Agreements [Member] | Warrants [Member]                      
Class Of Stock [Line Items]                      
Common stock shares agreed to sell, gross proceeds value | $           $ 5,800,000          
Warrants to issue shares of common stock           383,234          
Warrant reduced exercise price per share | $ / shares           $ 12.87          
Warrant additional exercise price per share | $ / shares           2.25          
Warrant Exercise Agreements [Member] | Common Stock [Member]                      
Class Of Stock [Line Items]                      
Common stock shares agreed to sell, gross proceeds value | $               $ 188,773      
Warrants to issue shares of common stock               64,171      
Warrant exercise price per share | $ / shares           $ 12.96          
Warrants exercisable term           5 years 6 months          
Issuance of common stock in connection with exercise of warrants, net of issuance costs, Shares               28,553      
Number of shares exercised               9,985      
Warrant Exercise Agreements [Member] | Common Stock [Member] | Maximum [Member]                      
Class Of Stock [Line Items]                      
Warrants to issue shares of common stock           383,235          
Warrant Exercise Agreements [Member] | Common Stock [Member] | Placement Agent [Member]                      
Class Of Stock [Line Items]                      
Warrant exercise price per share | $ / shares           $ 18.90          
Percentage of warrants to issue shares of common stock           5.00%          
Warrant Exercise Agreements [Member] | Common Stock [Member] | Placement Agent [Member] | Maximum [Member]                      
Class Of Stock [Line Items]                      
Warrants to issue shares of common stock           19,162          
Stock Purchase Agreement [Member] | Series X1 Preferred Stock [Member]                      
Class Of Stock [Line Items]                      
Common stock number of shares issued 1,004,111                    
Proceeds from issuance of common stock | $ $ 9,000,000                    
Preferred stock, par value | $ / shares   $ 0.001                  
Conversion of stock, shares converted   231,068                  
Preferred shares outstanding               108,070      
Issuance of preferred stock     199,112                
Preferred stock shares aggregate purchase price     99,100,000                
Proceeds from issuance of non-voting preferred stock in connection with PIPE transaction, net | $     $ 95,200,000                
Business combination additional commitments in equity financing | $     $ 9,000,000                
Stock Purchase Agreement [Member] | Common Stock [Member] | Series X1 Preferred Stock [Member]                      
Class Of Stock [Line Items]                      
Shares of common stock issued upon conversion of each share of preferred stock     55.5556                
Issuance of common stock in connection with conversion of Series X preferred stock, Shares   12,837,056                  
Stock Purchase Agreement [Member] | Common Stock [Member] | Series X Preferred Stock [Member]                      
Class Of Stock [Line Items]                      
Shares of common stock issued upon conversion of each share of preferred stock     55.5556                
Warrant Exchange Agreement and Exchange Agreements [Member] | Series X Preferred Stock [Member]                      
Class Of Stock [Line Items]                      
Preferred shares outstanding               6,203.98      
Warrant Exchange Agreement and Exchange Agreements [Member] | Common Stock [Member]                      
Class Of Stock [Line Items]                      
Common stock, shares outstanding               14,306,614      
Warrant Exchange Agreement and Exchange Agreements [Member] | Common Stock [Member] | Series X Preferred Stock [Member]                      
Class Of Stock [Line Items]                      
Shares of common stock issued upon conversion of each share of preferred stock               344,663      
Piper Jaffray & Co. [Member] | Equity Distribution Agreement [Member]                      
Class Of Stock [Line Items]                      
Equity distribution agreement maximum value of common shares issuable | $                     $ 9,800,000
Common stock number of shares issued               0      
Piper Jaffray & Co. [Member] | Equity Distribution Agreement [Member] | Common Stock [Member]                      
Class Of Stock [Line Items]                      
Common stock number of shares issued                 1,401    
Proceeds from issuance of common stock | $                 $ 110,000    
Exchanging Stockholders [Member] | Exchange Agreement [Member]                      
Class Of Stock [Line Items]                      
Reimbursement of expenses | $         $ 25,000            
Conversion of stock blocker provision percentage         9.99%            
Exchanging Stockholders [Member] | Exchange Agreement [Member] | Series X Preferred Stock [Member]                      
Class Of Stock [Line Items]                      
Preferred stock, par value | $ / shares         $ 0.001            
Conversion of stock, shares issued         3,796            
Number of designated preferred stock shares         10,000            
Exchanging Stockholders [Member] | Exchange Agreement [Member] | Common Stock [Member]                      
Class Of Stock [Line Items]                      
Conversion of stock, shares converted         210,888            
Shares of common stock issued upon conversion of each share of preferred stock         55.5556         55.5556  
BVF Exchanging Stockholders, Series X Exchanging Stockholders [Member] | Series X Exchange Agreement [Member] | Series X Preferred Stock [Member]                      
Class Of Stock [Line Items]                      
Conversion of stock, shares issued               6,203.98      
BVF Exchanging Stockholders, Series X Exchanging Stockholders [Member] | Series X Exchange Agreement [Member] | Common Stock [Member]                      
Class Of Stock [Line Items]                      
Conversion of stock, shares converted               344,666      
BVF Exchanging Stockholders | Warrant Exchange Agreement and Exchange Agreements [Member] | Common Stock [Member]                      
Class Of Stock [Line Items]                      
Warrants to issue shares of common stock               509,117