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Commitments and Contingencies - Additional Information (Detail)
 3 Months Ended 9 Months Ended 12 Months Ended
May 03, 2021
Sep. 30, 2021
USD ($)
Sep. 30, 2020
USD ($)
Sep. 30, 2021
USD ($)
ft²
OfficeSpace
Milestone
Sep. 30, 2020
USD ($)
Dec. 31, 2020
Milestone
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2015
USD ($)
Other Commitments [Line Items]                  
Rental expense   $ 63,000 $ 50,000 $ 189,000 $ 143,000        
Debt outstanding   0   0          
Indemnification obligations amount   0   0          
Contingent liabilities   0   $ 0          
Office of Chief Scientist of Israeli Ministry of Economy and Industry [Member]                  
Other Commitments [Line Items]                  
Grants received                 $ 500,000
ALS Therapy Development Foundation, Inc. License Agreement [Member]                  
Other Commitments [Line Items]                  
Fee due for milestones achieved             $ 1,000,000.0 $ 1,000,000.0  
Common stock issued in lieu of making a cash payment             $ 1,000,000.0 $ 1,000,000.0  
Number of Milestones Achieved | Milestone       0   0      
Remaining milestone payments for first licensed product   6,000,000.0   $ 6,000,000.0          
Annual license maintenance fee       100,000          
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 500 Million Aggregate Sales [Member]                  
Other Commitments [Line Items]                  
Reaching of aggregate net sales       500,000,000.0          
Amount of one-time milestone payment   15,000,000.0   15,000,000.0          
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 1 Billion Aggregate Sales [Member]                  
Other Commitments [Line Items]                  
Reaching of aggregate net sales       1,000,000,000.0          
Amount of one-time milestone payment   30,000,000.0   $ 30,000,000.0          
Minimum [Member]                  
Other Commitments [Line Items]                  
Remaining term of office lease       1 month          
Maximum [Member]                  
Other Commitments [Line Items]                  
Remaining term of office lease       18 months          
Maximum [Member] | ALS Therapy Development Foundation, Inc. License Agreement [Member]                  
Other Commitments [Line Items]                  
Development and regulatory milestone payments   $ 2,500,000   $ 2,500,000          
Irvine, California [Member]                  
Other Commitments [Line Items]                  
Area of office space | ft²       5,197          
Lease expiration date Dec. 31, 2022     Sep. 30, 2021          
Effective date of lease amendment Oct. 01, 2021                
Burlington, Massachusetts [Member]                  
Other Commitments [Line Items]                  
Lease expiration date       Jun. 30, 2021          
Lease expired term       Company had operating leases for four serviced office spaces in Burlington, Massachusetts that expired on June 30, 2021, which have been converted to monthly leases          
Number of office spaces operating lease | OfficeSpace       4