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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2021
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] |
Summary of All Option Activity Under 2007 Plan, 2014 Plan, 2020 Plan and Inducement Grants | The following table summarizes all option activity under the 2007 Plan, 2014 Plan, 2020 Plan and inducement grants:
|  | Shares Issuable Under Options |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term |  |  | Aggregate Intrinsic Value |
|  |  |  |  |  |  |  |  |  | (In years) |  |  |  |  |
Outstanding as of January 1, 2020 |  |  | 91,403 |  |  | $ | 139.96 |  |  |  | 8.2 |  |  | $ | — |
Granted |  |  | 2,191,462 |  |  |  | 9.15 |  |  |  |  |  |  |  |  |
Options Assumed |  |  | 1,346,398 |  |  |  | 7.58 |  |  |  |  |  |  |  |  |
Forfeited / Canceled |  |  | (7,784 | ) |  |  | 586.16 |  |  |  |  |  |  |  |  |
Outstanding as of December 31, 2020 |  |  | 3,621,479 |  |  |  | 10.63 |  |  |  | 8.9 |  |  | $ | — |
Granted |  |  | 702,836 |  |  |  | 10.69 |  |  |  |  |  |  |  |  |
Exercised |  |  | (174 | ) |  |  | 4.73 |  |  |  |  |  |  |  |  |
Forfeited / Canceled |  |  | (110,164 | ) |  |  | 19.50 |  |  |  |  |  |  |  |  |
Outstanding as of December 31, 2021 |  |  | 4,213,977 |  |  | $ | 10.33 |  |  |  | 8.4 |  |  | $ | — |
Options vested and expected to vest as of December 31, 2021 |  |  | 4,132,506 |  |  | $ | 10.18 |  |  |  | 8.2 |  |  | $ | — |
Options exercisable as of December 31, 2021 |  |  | 1,871,327 |  |  | $ | 11.64 |  |  |  | 7.8 |  |  | $ | — |
Schedule of Assumptions Used in Black-Scholes Option Pricing Model to Determine the Fair Value of Stock Options Granted | The following table presents the assumptions used in the Black-Scholes option pricing model to determine the fair value of stock options granted in the periods presented, as follows:
|  | Year Ended December 31, |
|  | 2021 |  |  | 2020 |
Expected stock price volatility |  | 105% - 110% |  |  | 74% - 87% |
Risk-free interest rate |  | 1% |  |  | 1% - 3% |
Expected life of option (in years) |  | 6.25 - 6.75 |  |  | 6 |
Estimated dividend yield |  | 0% |  |  | 0% |
Summary of RSU Activity | The following table shows the RSU activity, as follows:
|  | Shares Issuable Under RSUs |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term |  |  | Aggregate Intrinsic Value |
|  |  |  |  |  |  |  |  |  | (In years) |  |  |  |  |
Outstanding as of January 1, 2020 |  |  | 3,056 |  |  | $ | 66.96 |  |  |  | 9.2 |  |  | $ | — |
Granted |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
RSUs Vested |  |  | (3,056 | ) |  |  | 66.96 |  |  |  | 9.2 |  |  |  |  |
Forfeited / Canceled |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Outstanding as of December 31, 2020 |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |
Granted |  |  | 20,000 |  |  |  | 5.07 |  |  |  | 9.8 |  |  |  |  |
RSUs Vested |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Forfeited / Canceled |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
Outstanding as of December 31, 2021 |  |  | 20,000 |  |  | $ | 5.07 |  |  |  | 9.8 |  |  | $ | — |
RSUs vested and expected to vest as of December 31, 2021 |  |  | 20,000 |  |  | $ | 5.07 |  |  |  | 9.8 |  |  | $ | — |
RSUs exercisable as of December 31, 2021 |  |  | — |  |  | $ | — |  |  |  |  |  |  | $ | — |
Schedule of Stock-Based Compensation Expense Related to Stock-Based Awards | Total compensation expense related to all of the Company’s stock-based awards for the years ended December 31, 2021 and 2020 was comprised of the following (in thousands):
|  | Year Ended December 31, |
|  | 2021 |  |  | 2020 |
Stock-based compensation classified as: |  |  |  |  |  |  |  |
Research and development expense |  | $ | 3,166 |  |  | $ | 1,254 |
General and administrative expense |  |  | 4,738 |  |  |  | 1,917 |
Total stock-based compensation expense |  | $ | 7,904 |  |  | $ | 3,171 |

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