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Stockholders' Equity - Additional Information (Detail)
 12 Months Ended
Sep. 21, 2021
shares
Dec. 23, 2020
USD ($)
shares
Dec. 18, 2020
$ / shares
shares
Sep. 14, 2020
USD ($)
shares
Jun. 10, 2020
shares
Feb. 13, 2020
USD ($)
Feature
$ / shares
shares
Jan. 15, 2020
USD ($)
$ / shares
shares
Dec. 31, 2021
USD ($)
$ / shares
shares
Dec. 31, 2020
USD ($)
$ / shares
shares
Feb. 19, 2020
shares
Class Of Stock [Line Items]                    
Proceeds from issuance of non-voting preferred stock in connection with PIPE transaction, net | $                 $ 95,226,000  
Proceeds from issuance of common stock | $                 9,000,000  
Warrant inducement expense | $                 $ 4,829,000  
September 2020 Anelixis Acquisition [Member] | Stock Options [Member]                    
Class Of Stock [Line Items]                    
Estimated fair value, assumed and replaced value | $       $ 3,000,000.0            
Common Stock [Member]                    
Class Of Stock [Line Items]                    
Issuance of common stock in connection with conversion of Series X preferred stock, Shares                 210,888  
Common stock number of shares issued   1,004,111             1,004,111  
Proceeds from issuance of common stock | $   $ 9,000,000.0                
Issuance of common stock in connection with exercise of warrants, net of issuance costs, Shares                 421,772  
Warrants available for exercise               1,145,631    
Common Stock [Member] | September 2020 Anelixis Acquisition [Member]                    
Class Of Stock [Line Items]                    
Issuance of common stock       175,488            
Warrant [Member] | September 2020 Anelixis Acquisition [Member]                    
Class Of Stock [Line Items]                    
Estimated fair value, assumed and replaced value | $       $ 12,900,000            
Series X Non-voting Convertible Preferred Stock [Member]                    
Class Of Stock [Line Items]                    
Conversion of stock, shares converted         3,285          
Number of embedded features within preferred stock | Feature           2        
Issuance of common stock in connection with conversion of Series X preferred stock, Shares                 (3,796)  
Series X Non-voting Convertible Preferred Stock [Member] | Common Stock [Member]                    
Class Of Stock [Line Items]                    
Issuance of common stock in connection with conversion of Series X preferred stock, Shares         182,500          
Series X1 Preferred Stock [Member]                    
Class Of Stock [Line Items]                    
Preferred stock, par value | $ / shares     $ 0.001              
Shares of common stock issued upon conversion of each share of preferred stock               2,789,301    
Warrants available for exercise               50,207.419    
Series X1 Preferred Stock [Member] | September 2020 Anelixis Acquisition [Member]                    
Class Of Stock [Line Items]                    
Issuance of common stock       140,026            
Series X1 Preferred Stock [Member] | September 2020 Anelixis Acquisition [Member] | Stock Options [Member]                    
Class Of Stock [Line Items]                    
Estimated fair value, assumed and replaced       1,346,398            
Estimated fair value, assumed and replaced value | $       $ 6,000,000.0            
Series X1 Preferred Stock [Member] | Warrant [Member] | September 2020 Anelixis Acquisition [Member]                    
Class Of Stock [Line Items]                    
Estimated fair value, assumed and replaced       55,583.875            
Series X1 Non-voting Convertible Preferred Stock [Member]                    
Class Of Stock [Line Items]                    
Preferred stock, par value | $ / shares     $ 0.001         $ 0.001 $ 0.001  
Issuance of common stock in connection with conversion of Series X preferred stock, Shares     231,068           (231,068)  
Issuance of preferred stock                 199,112  
Series X1 Non-voting Convertible Preferred Stock [Member] | Common Stock [Member]                    
Class Of Stock [Line Items]                    
Issuance of common stock in connection with conversion of Series X preferred stock, Shares                 12,837,056  
2020 Common Stock Exchange Agreement [Member] | Exchanging Stockholders [Member]                    
Class Of Stock [Line Items]                    
Reimbursement of expenses | $           $ 25,000        
Conversion of stock blocker provision percentage           9.99%        
2020 Common Stock Exchange Agreement [Member] | Exchanging Stockholders [Member] | Common Stock [Member]                    
Class Of Stock [Line Items]                    
Conversion of stock, shares converted           210,888        
Shares of common stock issued upon conversion of each share of preferred stock           55.5556       55.5556
2020 Common Stock Exchange Agreement [Member] | Exchanging Stockholders [Member] | Series X Non-voting Convertible Preferred Stock [Member]                    
Class Of Stock [Line Items]                    
Conversion of stock, shares issued           3,796        
Number of designated preferred stock shares           10,000        
Preferred stock, par value | $ / shares           $ 0.001        
Stock Purchase Agreement [Member] | Series X Non-voting Convertible Preferred Stock [Member] | Common Stock [Member]                    
Class Of Stock [Line Items]                    
Shares of common stock issued upon conversion of each share of preferred stock       55.5556            
Conversion of stock blocker provision percentage       9.99%            
Stock Purchase Agreement [Member] | Series X1 Preferred Stock [Member]                    
Class Of Stock [Line Items]                    
Conversion of stock, shares converted     231,068              
Preferred stock, par value | $ / shares     $ 0.001              
Issuance of preferred stock       199,112            
Preferred stock shares aggregate purchase price       99,100,000            
Proceeds from issuance of non-voting preferred stock in connection with PIPE transaction, net | $       $ 95,200,000            
Business combination additional commitments in equity financing | $       $ 9,000,000.0            
Common stock number of shares issued   1,004,111                
Proceeds from issuance of common stock | $   $ 9,000,000.0                
Stock Purchase Agreement [Member] | Series X1 Preferred Stock [Member] | Common Stock [Member]                    
Class Of Stock [Line Items]                    
Shares of common stock issued upon conversion of each share of preferred stock       55.5556            
Issuance of common stock in connection with conversion of Series X preferred stock, Shares     12,837,056              
2020 Warrant Exercise Transactions [Member] | Warrants [Member]                    
Class Of Stock [Line Items]                    
Warrants to purchase common stock             383,235      
Warrant reduced exercise price per share | $ / shares             $ 12.87      
Warrant additional exercise price per share | $ / shares             $ 2.25      
Common stock shares gross proceeds value | $             $ 5,800,000      
2020 Warrant Exercise Transactions [Member] | Common Stock [Member]                    
Class Of Stock [Line Items]                    
Warrants to purchase common stock                 64,171  
Common stock shares gross proceeds value | $                 $ 188,773  
Warrant exercise price per share | $ / shares             $ 12.96      
Warrants exercisable term             5 years 6 months      
Issuance of common stock in connection with exercise of warrants, net of issuance costs, Shares                 28,553  
Number of shares exercised                 9,985  
2020 Warrant Exercise Transactions [Member] | Common Stock [Member] | Placement Agent [Member]                    
Class Of Stock [Line Items]                    
Warrant exercise price per share | $ / shares             $ 18.90      
Percentage of warrants to issue shares of common stock             5.00%      
2020 Warrant Exercise Transactions [Member] | Common Stock [Member] | Maximum [Member]                    
Class Of Stock [Line Items]                    
Warrants to purchase common stock             383,235      
2020 Warrant Exercise Transactions [Member] | Common Stock [Member] | Maximum [Member] | Placement Agent [Member]                    
Class Of Stock [Line Items]                    
Warrants to purchase common stock             19,162      
Series X Exchange Agreement [Member] | BVF Exchanging Stockholders, Series X Exchanging Stockholders [Member] | Common Stock [Member]                    
Class Of Stock [Line Items]                    
Conversion of stock, shares converted                 344,666  
Series X Exchange Agreement [Member] | BVF Exchanging Stockholders, Series X Exchanging Stockholders [Member] | Series X Non-voting Convertible Preferred Stock [Member]                    
Class Of Stock [Line Items]                    
Conversion of stock, shares issued                 6,203.98  
Warrant Exchange Agreement and Exchange Agreements [Member] | BVF Exchanging Stockholders | Common Stock [Member]                    
Class Of Stock [Line Items]                    
Warrants to purchase common stock                 509,117  
September 2021 Warrant Exchange Agreement [Member] | Common Stock [Member]                    
Class Of Stock [Line Items]                    
Warrants issued 298,692                  
September 2021 Warrant Exchange Agreement [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | Common Stock [Member]                    
Class Of Stock [Line Items]                    
Warrants exercisable for exchange 5,376.456                  
Equity Distribution Agreement [Member] | Jeffries LLC [Member]                    
Class Of Stock [Line Items]                    
Common stock number of shares issued               0    
Equity distribution agreement maximum value of common shares issuable | $               $ 75,000,000.0