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Stock-Based Compensation - Summary of All Option Activity Under 2007 Plan, 2014 Plan, 2020 Plan and Inducement Grants (Details) - $ / shares
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Shares Issuable Under Options      
Outstanding, beginning balance 3,621,479 91,403  
Granted 702,836 2,191,462  
Options Assumed   1,346,398  
Exercised (174)    
Forfeited / Canceled (110,164) (7,784)  
Outstanding, ending balance 4,213,977 3,621,479 91,403
Options vested and expected to vest as of December 31, 2021 4,132,506    
Options exercisable as of December 31, 2021 1,871,327    
Weighted Average Exercise Price      
Outstanding, beginning balance $ 10.63 $ 139.96  
Granted 10.69 9.15  
Options Assumed   7.58  
Exercised 4.73    
Forfeited / Canceled 19.50 586.16  
Outstanding, ending balance 10.33 $ 10.63 $ 139.96
Options vested and expected to vest as of December 31, 2021 10.18    
Options exercisable as of December 31, 2021 $ 11.64    
Weighted Average Remaining Contractual Term (In years)      
Outstanding, balance 8 years 4 months 24 days 8 years 10 months 24 days 8 years 2 months 12 days
Options vested and expected to vest as of December 31, 2021 8 years 2 months 12 days    
Options exercisable as of December 31, 2021 7 years 9 months 18 days