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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2022
Income Tax Disclosure [Abstract] |
Summary of Loss Before Income Taxes | Loss before income taxes are as follows (in thousands):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |
Losses before income taxes: |  |  |  |  |  |
U.S. |  | $ | (88,159 | ) |  | $ | (37,055 | )
Non-U.S. |  |  | 193 |  |  |  | 195 |
Total |  | $ | (87,966 | ) |  | $ | (36,860 | )
Summary of Provision (Benefit) for Income Taxes | The provision (benefit) for income taxes are as follows (in thousands):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |
Current: |  |  |  |  |  |
Federal |  | $ | — |  |  | $ | — |
State |  |  | — |  |  |  | — |
Foreign |  |  | — |  |  |  | — |
|  |  | — |  |  |  | — |
Deferred: |  |  |  |  |  |
Federal |  |  | — |  |  |  | (2,746 | )
State |  |  | — |  |  |  | 392 |
Foreign |  |  | — |  |  |  | — |
|  |  | — |  |  |  | (2,354 | )
Provision (benefit) for income taxes |  | $ | — |  |  | $ | (2,354 | )
Reconciliation of U.S. Federal Statutory Income Tax Rate | A reconciliation of the U.S. federal statutory income tax rate to the Company’s effective income tax rate is as follows (in thousands):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |
Statutory Federal income tax rate |  | $ | (18,473 | ) |  | $ | (7,741 | )
State income taxes, net of Federal tax benefits |  |  | (2,678 | ) |  |  | (445 | )
Tax credits |  |  | (1,046 | ) |  |  | (651 | )
Stock-based compensation |  |  | 986 |  |  |  | 651 |
Permanent items |  |  | 3 |  |  |  | 2 |
State rate differential |  |  | 274 |  |  |  | 235 |
NOL true-up |  |  | (337 | ) |  |  | (991 | )
Other |  |  | 114 |  |  |  | 146 |
Goodwill impairment |  |  | 11,697 |  |  |  | — |
Change in valuation allowance |  |  | 9,460 |  |  |  | 6,440 |
Total provision (benefit) for income taxes |  | $ | — |  |  | $ | (2,354 | )
Schedule of Significant Components Deferred Tax Assets and Liabilities | Significant components of the Company’s deferred tax assets and liabilities as of December 31, 2022 and 2021 consisted of the following (in thousands):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |
Net operating loss carryforwards |  | $ | 15,230 |  |  | $ | 12,531 |
Research and development tax credits |  |  | 2,294 |  |  |  | 1,356 |
Accruals and reserves |  |  | 452 |  |  |  | 296 |
Research expenditures |  |  | 5,264 |  |  |  | — |
Stock-based compensation |  |  | 2,874 |  |  |  | 1,867 |
Depreciation and amortization |  |  | 1,595 |  |  |  | 1,713 |
Lease liability |  |  | 179 |  |  |  | 171 |
Total deferred tax assets |  |  | 27,888 |  |  |  | 17,934 |
Right-of-use asset |  |  | (178 | ) |  |  | (171 | )
Acquired IPR&D |  |  | (7,787 | ) |  |  | (7,192 | )
Total deferred tax liabilities |  |  | (7,965 | ) |  |  | (7,363 | )
Less: valuation allowance |  |  | (21,675 | ) |  |  | (12,323 | )
Net deferred tax liabilities |  | $ | (1,752 | ) |  | $ | (1,752 | )
Reconciliation of Beginning and Ending Amounts of Unrecognized Tax Benefits | The following table reconciles the beginning and ending amounts of unrecognized tax benefits for the years presented (in thousands):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |
Gross unrecognized tax benefits at the beginning of the year |  | $ | 1,469 |  |  | $ | 764 |
Additions from tax positions taken in the current year |  |  | 914 |  |  |  | 712 |
Additions from tax positions taken in prior years |  |  | 281 |  |  |  | — |
Reductions from tax positions taken in prior years |  |  | — |  |  |  | (7 | )
Gross unrecognized tax benefits at the end of the year |  | $ | 2,664 |  |  | $ | 1,469 |

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