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Commitments and Contingencies - Additional Information (Detail) |  |  | 12 Months Ended |
--- | --- | --- | --- | ---
Aug. 12, 2022 | Nov. 04, 2021 ft² | Dec. 31, 2022 USD ($) ft² Milestone | Dec. 31, 2021 USD ($) Milestone | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2015 USD ($)
Other Commitments [Line Items] |  |  |  |  |  |  |
Rental expense |  |  | $ 300,000 | $ 300,000 |  |  |
Remaining term of office lease |  |  | 2 years |  |  |  |
Debt outstanding |  |  | $ 0 |  |  |  |
Indemnification obligations amount |  |  | 0 |  |  |  |
Contingent liabilities |  |  | $ 0 | $ 0 |  |  |
Office of Chief Scientist of Israeli Ministry of Economy and Industry [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Grants received |  |  |  |  |  |  | $ 500,000
ALS Therapy Development Foundation, Inc. License Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Fee due for milestones achieved |  |  |  |  | $ 1,000,000.0 | $ 1,000,000.0 |
Common stock issued in lieu of making a cash payment |  |  |  |  | $ 1,000,000.0 | $ 1,000,000.0 |
Number of Milestones Achieved | Milestone |  |  | 0 | 0 |  |  |
Remaining milestone payments for first licensed product |  |  | $ 6,000,000.0 |  |  |  |
Annual License Maintenance Fee |  |  | 100,000 |  |  |  |
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 500 Million Aggregate Sales [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Reaching of aggregate net sales |  |  | 500,000,000.0 |  |  |  |
Amount of one-time milestone payment |  |  | 15,000,000.0 |  |  |  |
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 1 Billion Aggregate Sales [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Reaching of aggregate net sales |  |  | 1,000,000,000.0 |  |  |  |
Amount of one-time milestone payment |  |  | 30,000,000.0 |  |  |  |
Maximum [Member] | ALS Therapy Development Foundation, Inc. License Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Development and regulatory milestone payments |  |  | $ 2,500,000 |  |  |  |
Irvine, California [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Area of office space | ft² |  |  | 5,197 |  |  |  |
Lease expiration date | Dec. 31, 2024 |  | Dec. 31, 2022 |  |  |  |
Effective date of lease amendment | Jan. 01, 2023 |  |  |  |  |  |
Burlington, Massachusetts [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Area of office space | ft² |  | 6,138 |  |  |  |  |
Lease expiration date |  | Nov. 20, 2024 |  |  |  |  |

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