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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2022
Share-Based Payment Arrangement [Abstract] |
Summary of All Option Activity Under 2007 Plan, 2014 Plan, 2020 Plan and Inducement Grants | The following table summarizes all option activity under the 2007 Plan, 2014 Plan, 2020 Plan and inducement grants:
|  | Shares Issuable Under Options |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term |  |  | Aggregate Intrinsic Value |
|  |  |  |  |  |  |  | (In years) |  |  |  |
Outstanding as of January 1, 2021 |  |  | 3,621,479 |  |  | $ | 10.63 |  |  |  | 8.9 |  |  | $ | — |
Granted |  |  | 702,836 |  |  |  | 10.69 |  |  |  | — |  |  |  | — |
Options Assumed |  |  | (174 | ) |  |  | 4.73 |  |  |  | — |  |  |  | — |
Forfeited / Canceled |  |  | (110,164 | ) |  |  | 19.50 |  |  |  | — |  |  |  | — |
Outstanding as of December 31, 2021 |  |  | 4,213,977 |  |  | $ | 10.33 |  |  |  | 8.4 |  |  | $ | — |
Granted |  |  | 1,267,700 |  |  |  | 3.81 |  |  |  | — |  |  |  | — |
Forfeited / Canceled |  |  | (263,644 | ) |  |  | 12.12 |  |  |  | — |  |  |  | — |
Outstanding as of December 31, 2022 |  |  | 5,218,033 |  |  | $ | 8.69 |  |  |  | 8.1 |  |  | $ | — |
Options vested and expected to vest as of December 31, 2022 |  |  | 5,218,033 |  |  | $ | 8.69 |  |  |  | 8.1 |  |  | $ | — |
Options exercisable as of December 31, 2022 |  |  | 3,076,338 |  |  | $ | 8.72 |  |  |  | 7.0 |  |  | $ | — |
Schedule of Assumptions Used in Black-Scholes Option Pricing Model to Determine the Fair Value of Stock Options Granted | The following table presents the assumptions used in the Black-Scholes option pricing model to determine the fair value of stock options granted in the periods presented, as follows:
|  | Year Ended December 31,
|  | 2022 |  | 2021
Expected stock price volatility |  | 81% - 84% |  | 105% - 110%
Risk-free interest rate |  | 1.8% - 4.2% |  | 1%
Expected life of option (in years) |  | 6.25 - 6.50 |  | 6.25 - 6.75
Estimated dividend yield |  | 0% |  | 0%
Summary of RSU Activity | The following table shows the RSU activity, as follows:
|  | Shares Issuable Under RSUs |  |  | Weighted Average Exercise Price |  |  | Aggregate Intrinsic Value |
Outstanding as of January 1, 2021 |  |  | — |  |  | $ | — |  |  | $ | — |
Granted |  |  | 20,000 |  |  |  | 5.07 |  |  |  | — |
RSUs Vested |  |  | — |  |  |  | — |  |  |  | — |
Forfeited / Canceled |  |  | — |  |  |  | — |  |  |  | — |
Outstanding as of December 31, 2021 |  |  | 20,000 |  |  | $ | 5.07 |  |  | $ | — |
Granted |  |  | 15,000 |  |  |  | 2.47 |  |  |  | — |
RSUs Vested |  |  | (20,000 | ) |  |  | 5.07 |  |  |  | — |
Forfeited / Canceled |  |  | — |  |  |  | — |  |  |  | — |
Outstanding as of December 31, 2022 |  |  | 15,000 |  |  | $ | 2.47 |  |  | $ | — |
RSUs vested and expected to vest as of December 31, 2022 |  |  | 15,000 |  |  | $ | 2.47 |  |  | $ | — |
RSUs exercisable as of December 31, 2022 |  |  | — |  |  | $ | — |  |  | $ | — |
Schedule of Stock-Based Compensation Expense Related to Stock-Based Awards | Total compensation expense related to all of the Company’s stock-based awards for the years ended December 31, 2022 and 2021 was comprised of the following (in thousands):
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |
Stock-based compensation classified as: |  |  |  |  |  |
Research and development expense |  | $ | 3,230 |  |  | $ | 3,166 |
General and administrative expense |  |  | 4,923 |  |  |  | 4,738 |
Total stock-based compensation expense |  | $ | 8,153 |  |  | $ | 7,904 |

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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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