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Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2022

Share-Based Payment Arrangement [Abstract]

Summary of All Option Activity Under 2007 Plan, 2014 Plan, 2020 Plan and Inducement Grants

The following table summarizes all option activity under the 2007 Plan, 2014 Plan, 2020 Plan and inducement grants:

		Shares Issuable Under Options				Weighted Average Exercise Price				Weighted Average Remaining Contractual Term				Aggregate Intrinsic Value
										(In years)
Outstanding as of January 1, 2021			3,621,479			$	10.63				8.9			$	—
Granted			702,836				10.69				—				—
Options Assumed			(174	)			4.73				—				—
Forfeited / Canceled			(110,164	)			19.50				—				—
Outstanding as of December 31, 2021			4,213,977			$	10.33				8.4			$	—
Granted			1,267,700				3.81				—				—
Forfeited / Canceled			(263,644	)			12.12				—				—
Outstanding as of December 31, 2022			5,218,033			$	8.69				8.1			$	—
Options vested and expected to vest as of    December 31, 2022			5,218,033			$	8.69				8.1			$	—
Options exercisable as of December 31, 2022			3,076,338			$	8.72				7.0			$	—

Schedule of Assumptions Used in Black-Scholes Option Pricing Model to Determine the Fair Value of Stock Options Granted

The following table presents the assumptions used in the Black-Scholes option pricing model to determine the fair value of stock options granted in the periods presented, as follows:

		Year Ended December 31,
		2022		2021
Expected stock price volatility		81% - 84%		105% - 110%
Risk-free interest rate		1.8% - 4.2%		1%
Expected life of option (in years)		6.25 - 6.50		6.25 - 6.75
Estimated dividend yield		0%		0%

Summary of RSU Activity

The following table shows the RSU activity, as follows:

		Shares Issuable Under RSUs				Weighted Average Exercise Price				Aggregate Intrinsic Value
Outstanding as of January 1, 2021			—			$	—			$	—
Granted			20,000				5.07				—
RSUs Vested			—				—				—
Forfeited / Canceled			—				—				—
Outstanding as of December 31, 2021			20,000			$	5.07			$	—
Granted			15,000				2.47				—
RSUs Vested			(20,000	)			5.07				—
Forfeited / Canceled			—				—				—
Outstanding as of December 31, 2022			15,000			$	2.47			$	—
RSUs vested and expected to vest as of    December 31, 2022			15,000			$	2.47			$	—
RSUs exercisable as of December 31, 2022			—			$	—			$	—

Schedule of Stock-Based Compensation Expense Related to Stock-Based Awards

Total compensation expense related to all of the Company’s stock-based awards for the years ended December 31, 2022 and 2021 was comprised of the following (in thousands):

		Year Ended December 31,
		2022				2021
Stock-based compensation classified as:
Research and development expense		$	3,230			$	3,166
General and administrative expense			4,923				4,738
Total stock-based compensation expense		$	8,153			$	7,904

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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