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Commitments and Contingencies - Additional Information (Detail)
 12 Months Ended
Aug. 12, 2022
Nov. 04, 2021
ft²
Dec. 31, 2022
USD ($)
ft²
Milestone
Dec. 31, 2021
USD ($)
Milestone
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2015
USD ($)
Other Commitments [Line Items]              
Rental expense     $ 300,000 $ 300,000      
Remaining term of office lease     2 years        
Debt outstanding     $ 0        
Indemnification obligations amount     0        
Contingent liabilities     $ 0 $ 0      
Office of Chief Scientist of Israeli Ministry of Economy and Industry [Member]              
Other Commitments [Line Items]              
Grants received             $ 500,000
ALS Therapy Development Foundation, Inc. License Agreement [Member]              
Other Commitments [Line Items]              
Fee due for milestones achieved         $ 1,000,000.0 $ 1,000,000.0  
Common stock issued in lieu of making a cash payment         $ 1,000,000.0 $ 1,000,000.0  
Number of Milestones Achieved | Milestone     0 0      
Remaining milestone payments for first licensed product     $ 6,000,000.0        
Annual License Maintenance Fee     100,000        
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 500 Million Aggregate Sales [Member]              
Other Commitments [Line Items]              
Reaching of aggregate net sales     500,000,000.0        
Amount of one-time milestone payment     15,000,000.0        
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 1 Billion Aggregate Sales [Member]              
Other Commitments [Line Items]              
Reaching of aggregate net sales     1,000,000,000.0        
Amount of one-time milestone payment     30,000,000.0        
Maximum [Member] | ALS Therapy Development Foundation, Inc. License Agreement [Member]              
Other Commitments [Line Items]              
Development and regulatory milestone payments     $ 2,500,000        
Irvine, California [Member]              
Other Commitments [Line Items]              
Area of office space | ft²     5,197        
Lease expiration date Dec. 31, 2024   Dec. 31, 2022        
Effective date of lease amendment Jan. 01, 2023            
Burlington, Massachusetts [Member]              
Other Commitments [Line Items]              
Area of office space | ft²   6,138          
Lease expiration date   Nov. 20, 2024