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Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended
Dec. 18, 2020
Mar. 31, 2023
Mar. 31, 2022
Dec. 31, 2022
Dec. 31, 2021
Mar. 31, 2020
Summary Of Significant Accounting Policies [Line Items]            
Net loss   $ (10,772) $ (9,864)      
Cash and cash equivalents   46,485 $ 76,677 $ 56,409 $ 84,833  
Accumulated deficit   $ (213,637)   (202,865)    
Cash, cash equivalents and restricted cash, maturity period   three months or less        
Cash equivalents   $ 9,400   $ 9,300    
Basic weighted average shares outstanding   14,285,905 14,330,693      
Warrants exercise price   $ 0.001        
Antidilutive securities excluded from computation of earnings per share, amount   10,238,198 8,316,473      
2014 Stock Incentive Plan [Member]            
Summary Of Significant Accounting Policies [Line Items]            
Increase in number of shares of common stock authorized for issuance           28,816
Common stock, number of shares initially reserved for issuance   0        
2014 Employee Stock Purchase Plan [Member]            
Summary Of Significant Accounting Policies [Line Items]            
Increase in number of shares of common stock authorized for issuance           7,204
Common stock, number of shares initially reserved for issuance   24,077        
2020 Plan [Member]            
Summary Of Significant Accounting Policies [Line Items]            
Common stock, number of shares initially reserved for issuance 4,860,000 1,576,570        
Percentage of issued and outstanding shares of common stock 15.00%          
Stock Options [Member] | Board of Directors [Member]            
Summary Of Significant Accounting Policies [Line Items]            
Expected life assumption using simplified method, description   For stock options granted to the Company’s board of directors (the “Board”), the Company determined the expected life assumption using the simplified method as the starting point with an average period of twelve (12) months added to take into account for the extended range of time of 12 to 18 months vested stock options granted to Board members may be exercised upon termination.        
Expected life assumption using simplified method   12 months        
Stock Options [Member] | Minimum [Member] | Board of Directors [Member]            
Summary Of Significant Accounting Policies [Line Items]            
Vesting period of stock options granted   12 months        
Stock Options [Member] | Maximum [Member] | Board of Directors [Member]            
Summary Of Significant Accounting Policies [Line Items]            
Vesting period of stock options granted   18 months        
Warrants [Member]            
Summary Of Significant Accounting Policies [Line Items]            
Basic weighted average shares outstanding   509,117        
Anelixis Therapeutics, LLC and Otic Pharma, Ltd.            
Summary Of Significant Accounting Policies [Line Items]            
Ownership interest percentage   100.00%        
Otic Pharma, Inc. [Member]            
Summary Of Significant Accounting Policies [Line Items]            
Ownership interest percentage   100.00%