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Commitments and Contingencies - Additional Information (Detail)
 3 Months Ended 6 Months Ended 12 Months Ended
Jan. 01, 2023
Nov. 04, 2021
ft²
Jun. 30, 2023
USD ($)
Jun. 30, 2022
USD ($)
Jun. 30, 2023
USD ($)
ft²
Milestone
Jun. 30, 2022
USD ($)
Dec. 31, 2022
USD ($)
Milestone
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Sep. 30, 2022
USD ($)
Dec. 31, 2015
USD ($)
Other Commitments [Line Items]                      
Rental expense     $ 100,000 $ 100,000 $ 200,000 $ 200,000          
Indemnification obligations amount     0   0            
Contingent Liabilities     0   $ 0            
Office of Chief Scientist of Israeli Ministry of Economy and Industry [Member]                      
Other Commitments [Line Items]                      
Grants received                     $ 500,000
ALS Therapy Development Foundation, Inc. License Agreement [Member]                      
Other Commitments [Line Items]                      
Fee due for milestones achieved               $ 1,000,000.0 $ 1,000,000.0    
Common stock issued in lieu of making a cash payment               $ 1,000,000.0 $ 1,000,000.0    
Number of Milestones Achieved | Milestone         0   0        
Remaining milestone payments for first licensed product                   $ 6,000,000.0  
Annual License Maintenance Fee             $ 100,000        
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 500 Million Aggregate Sales [Member]                      
Other Commitments [Line Items]                      
Reaching of aggregate net sales         $ 500,000,000.0            
Amount of one-time milestone payment     15,000,000.0   15,000,000.0            
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 1 Billion Aggregate Sales [Member]                      
Other Commitments [Line Items]                      
Reaching of aggregate net sales         1,000,000,000.0            
Amount of one-time milestone payment     $ 30,000,000.0   $ 30,000,000.0            
Maximum [Member] | ALS Therapy Development Foundation, Inc. License Agreement [Member]                      
Other Commitments [Line Items]                      
Development and regulatory milestone payments                   $ 2,500,000  
Irvine, California [Member]                      
Other Commitments [Line Items]                      
Area of office space | ft²         5,197            
Lease expiration date Dec. 31, 2024                    
Burlington, Massachusetts [Member]                      
Other Commitments [Line Items]                      
Area of office space | ft²   6,138                  
Lease expiration date   Nov. 20, 2024