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Stockholders' Equity - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands |  |  |  |  |  | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
May 16, 2023 | May 05, 2023 | Jan. 11, 2022 | Sep. 21, 2021 | Mar. 31, 2021 | Dec. 31, 2023 | Dec. 31, 2022 | Nov. 06, 2023 | Nov. 02, 2023 | Jul. 14, 2023 | Jul. 10, 2023 | Apr. 28, 2023
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares issued |  |  |  |  |  | 24,213,130 | 13,776,788 |  |  |  |  |
Common stock, par value |  |  |  |  |  | $ 0.001 | $ 0.001 |  |  |  |  |
Warrant exercise price per share |  |  |  |  |  | $ 0.001 |  |  |  |  |  |
Preferred stock, shares authorized |  |  |  |  |  | 5,000,000 | 5,000,000 |  |  |  |  |
Preferred stock, par value |  |  |  |  |  | $ 0.001 | $ 0.001 |  |  |  |  |
Warrants available for exercise |  |  |  |  |  | 21,564,302 |  |  |  |  |  |
Proceeds from issuances of common stock and pre-funded warrants, net |  |  |  |  |  | $ 33,017 |  |  |  |  |  |
Armistice Capital Master Fund Ltd [Member] | Securities Purchase Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares issued |  |  |  |  |  |  |  | 653,000 |  | 501,197 |  |
Warrant exercise price per share |  |  |  |  |  |  |  |  | $ 0.001 |  | $ 0.001 |
Number of pre-funded warrants exercised for common stock |  |  |  |  |  |  |  |  | 653,000 |  | 501,197 |
Series X1 Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Shares of common stock issued upon conversion of each share of preferred stock |  |  |  |  |  | 2,789,301 |  |  |  |  |  |
Warrants available for exercise |  |  |  |  |  | 50,207.419 |  |  |  |  |  |
Series X Non-voting Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, shares authorized |  |  |  |  |  | 10,000 | 10,000 |  |  |  |  |
Preferred stock, shares issued |  |  |  |  |  | 4,422 | 6,204 |  |  |  |  |
Preferred stock, shares outstanding |  |  |  |  |  | 4,422 | 6,204 |  |  |  |  |
Series X1 Non-voting Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, shares authorized |  |  |  |  |  | 515,000 | 515,000 |  |  |  |  |
Preferred stock, par value |  |  |  |  |  | $ 0.001 | $ 0.001 |  |  |  |  |
Preferred stock, shares issued |  |  |  |  |  | 110,086 | 117,970 |  |  |  |  |
Preferred stock, shares outstanding |  |  |  |  |  | 110,086 | 117,970 |  |  |  |  |
Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Warrants available for exercise |  |  |  |  |  | 21,564,302 |  |  |  |  |  |
Common Stock [Member] | September 2021 Warrant Exchange Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Warrants issued |  |  |  | 298,692 |  |  |  |  |  |  |  |
Common Stock [Member] | Series X Non-voting Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Shares of common stock issued upon conversion of each share of preferred stock |  |  |  |  |  | 55.5556 |  |  |  |  |  |
Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Shares of common stock issued upon conversion of each share of preferred stock |  |  |  |  |  | 55.5556 |  |  |  |  |  |
Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | September 2021 Warrant Exchange Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercisable for exchange |  |  |  | 5,376.456 |  |  |  |  |  |  |  |
Private Placement Warrants [Member] | Accredited Investor [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price per share |  |  |  |  |  |  |  |  |  |  |  | $ 3
Private Placement Warrants [Member] | Securities Purchase Agreement Initial Closing [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common warrants issued |  | $ 35,000 |  |  |  |  |  |  |  |  |  |
Proceeds from issuances of common stock and pre-funded warrants, net |  | $ 33,000 |  |  |  |  |  |  |  |  |  |
Private Placement Warrants [Member] | Securities Purchase Agreement Initial Closing [Member] | Accredited Investor [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares issued |  | 8,730,168 |  |  |  |  |  |  |  |  |  | 15,151,518
Common stock, par value |  |  |  |  |  |  |  |  |  |  |  | $ 0.001
Common stock warrants exercisable |  | 15,151,518 |  |  |  |  |  |  |  |  |  | 15,151,518
Common warrants issued |  | $ 45,500 |  |  |  |  |  |  |  |  |  |
Private Placement Warrants [Member] | Securities Purchase Agreement Second Closing [Member] | Accredited Investor [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares issued |  |  |  |  |  |  |  |  |  |  |  | 20,202,024
Private Placement Warrants [Member] | Securities Purchase Agreement Second and Third Closing [Member] | Accredited Investor [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares issued |  |  |  |  |  |  |  |  |  |  |  | 25,252,530
Common warrants issued |  | $ 105,000 |  |  |  |  |  |  |  |  |  |
Private Placement Warrants [Member] | Common Stock [Member] | Securities Purchase Agreement Initial Closing [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares issued |  | 8,730,168 |  |  |  |  |  |  |  |  |  |
Private Placement Warrants [Member] | Pre-funded Warrants [Member] | Accredited Investor [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price per share |  |  |  |  |  |  |  |  |  |  |  | $ 0.001
Private Placement Warrants [Member] | Pre-funded Warrants [Member] | Securities Purchase Agreement Initial Closing [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares issued |  | 6,421,350 |  |  |  |  |  |  |  |  |  |
Maximum [Member] | Common Stock [Member] | Series X Non-voting Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Conversion of preferred stock, conversion blocker, percent |  |  |  |  |  | 9.99% |  |  |  |  |  |
Maximum [Member] | Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Conversion of preferred stock, conversion blocker, percent |  |  |  |  |  | 9.99% |  |  |  |  |  |
Minimum [Member] | Common Stock [Member] | Series X Non-voting Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Conversion of preferred stock, conversion blocker, percent |  |  |  |  |  | 9.90% |  |  |  |  |  |
Minimum [Member] | Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Conversion of preferred stock, conversion blocker, percent |  |  |  |  |  | 9.90% |  |  |  |  |  |
Jefferies LLC [Member] | ATM Program [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common stock number of shares issued |  |  |  |  |  | 0 | 0 |  |  |  |  |
Equity distribution agreement maximum value of common shares issuable |  |  |  |  | $ 75,000 |  |  |  |  |  |  |
Public float minimum balance to be maintained |  |  |  |  |  | $ 75,000 |  |  |  |  |  |
Jefferies LLC [Member] | ATM Program [Member] | Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common stock number of shares issued |  |  |  |  | 0 |  |  |  |  |  |  |
Jefferies LLC [Member] | Maximum [Member] | ATM Program [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Equity distribution agreement maximum value of common shares issuable |  |  |  |  |  | $ 12,300 |  |  |  |  |  |
BVF Exchanging Stockholders [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | Series X1 Exchange Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Conversion of stock, shares issued |  |  | 9,899.99 |  |  |  |  |  |  |  |  |
BVF Exchanging Stockholders [Member] | Common Stock [Member] | Series X1 Exchange Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Conversion of stock, shares converted |  |  | 550,000 |  |  |  |  |  |  |  |  |
Cormorant Global Healthcare Master Fund LP [Member] | Series X Non-voting Convertible Preferred Stock [Member] | Conversion Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Conversion of stock, shares converted | 1,782 |  |  |  |  |  |  |  |  |  |  |
Cormorant Global Healthcare Master Fund LP [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | Conversion Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Conversion of stock, shares converted | 7,883.586 |  |  |  |  |  |  |  |  |  |  |
Cormorant Global Healthcare Master Fund LP [Member] | Common Stock [Member] | Series X Non-voting Convertible Preferred Stock [Member] | Conversion Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Conversion of stock, shares issued | 99,000 |  |  |  |  |  |  |  |  |  |  |
Cormorant Global Healthcare Master Fund LP [Member] | Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | Conversion Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Conversion of stock, shares issued | 437,977 |  |  |  |  |  |  |  |  |  |  |

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