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Stockholders' Equity - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 12 Months Ended
May 16, 2023
May 05, 2023
Jan. 11, 2022
Sep. 21, 2021
Mar. 31, 2021
Dec. 31, 2023
Dec. 31, 2022
Nov. 06, 2023
Nov. 02, 2023
Jul. 14, 2023
Jul. 10, 2023
Apr. 28, 2023
Class Of Stock [Line Items]                        
Common stock, shares issued           24,213,130 13,776,788          
Common stock, par value           $ 0.001 $ 0.001          
Warrant exercise price per share           $ 0.001            
Preferred stock, shares authorized           5,000,000 5,000,000          
Preferred stock, par value           $ 0.001 $ 0.001          
Warrants available for exercise           21,564,302            
Proceeds from issuances of common stock and pre-funded warrants, net           $ 33,017            
Armistice Capital Master Fund Ltd [Member] | Securities Purchase Agreement [Member]                        
Class Of Stock [Line Items]                        
Common stock, shares issued               653,000   501,197    
Warrant exercise price per share                 $ 0.001   $ 0.001  
Number of pre-funded warrants exercised for common stock                 653,000   501,197  
Series X1 Preferred Stock [Member]                        
Class Of Stock [Line Items]                        
Shares of common stock issued upon conversion of each share of preferred stock           2,789,301            
Warrants available for exercise           50,207.419            
Series X Non-voting Convertible Preferred Stock [Member]                        
Class Of Stock [Line Items]                        
Preferred stock, shares authorized           10,000 10,000          
Preferred stock, shares issued           4,422 6,204          
Preferred stock, shares outstanding           4,422 6,204          
Series X1 Non-voting Convertible Preferred Stock [Member]                        
Class Of Stock [Line Items]                        
Preferred stock, shares authorized           515,000 515,000          
Preferred stock, par value           $ 0.001 $ 0.001          
Preferred stock, shares issued           110,086 117,970          
Preferred stock, shares outstanding           110,086 117,970          
Common Stock [Member]                        
Class Of Stock [Line Items]                        
Warrants available for exercise           21,564,302            
Common Stock [Member] | September 2021 Warrant Exchange Agreement [Member]                        
Class Of Stock [Line Items]                        
Warrants issued       298,692                
Common Stock [Member] | Series X Non-voting Convertible Preferred Stock [Member]                        
Class Of Stock [Line Items]                        
Shares of common stock issued upon conversion of each share of preferred stock           55.5556            
Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member]                        
Class Of Stock [Line Items]                        
Shares of common stock issued upon conversion of each share of preferred stock           55.5556            
Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | September 2021 Warrant Exchange Agreement [Member]                        
Class Of Stock [Line Items]                        
Warrants exercisable for exchange       5,376.456                
Private Placement Warrants [Member] | Accredited Investor [Member]                        
Class Of Stock [Line Items]                        
Warrant exercise price per share                       $ 3
Private Placement Warrants [Member] | Securities Purchase Agreement Initial Closing [Member]                        
Class Of Stock [Line Items]                        
Common warrants issued   $ 35,000                    
Proceeds from issuances of common stock and pre-funded warrants, net   $ 33,000                    
Private Placement Warrants [Member] | Securities Purchase Agreement Initial Closing [Member] | Accredited Investor [Member]                        
Class Of Stock [Line Items]                        
Common stock, shares issued   8,730,168                   15,151,518
Common stock, par value                       $ 0.001
Common stock warrants exercisable   15,151,518                   15,151,518
Common warrants issued   $ 45,500                    
Private Placement Warrants [Member] | Securities Purchase Agreement Second Closing [Member] | Accredited Investor [Member]                        
Class Of Stock [Line Items]                        
Common stock, shares issued                       20,202,024
Private Placement Warrants [Member] | Securities Purchase Agreement Second and Third Closing [Member] | Accredited Investor [Member]                        
Class Of Stock [Line Items]                        
Common stock, shares issued                       25,252,530
Common warrants issued   $ 105,000                    
Private Placement Warrants [Member] | Common Stock [Member] | Securities Purchase Agreement Initial Closing [Member]                        
Class Of Stock [Line Items]                        
Common stock, shares issued   8,730,168                    
Private Placement Warrants [Member] | Pre-funded Warrants [Member] | Accredited Investor [Member]                        
Class Of Stock [Line Items]                        
Warrant exercise price per share                       $ 0.001
Private Placement Warrants [Member] | Pre-funded Warrants [Member] | Securities Purchase Agreement Initial Closing [Member]                        
Class Of Stock [Line Items]                        
Common stock, shares issued   6,421,350                    
Maximum [Member] | Common Stock [Member] | Series X Non-voting Convertible Preferred Stock [Member]                        
Class Of Stock [Line Items]                        
Conversion of preferred stock, conversion blocker, percent           9.99%            
Maximum [Member] | Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member]                        
Class Of Stock [Line Items]                        
Conversion of preferred stock, conversion blocker, percent           9.99%            
Minimum [Member] | Common Stock [Member] | Series X Non-voting Convertible Preferred Stock [Member]                        
Class Of Stock [Line Items]                        
Conversion of preferred stock, conversion blocker, percent           9.90%            
Minimum [Member] | Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member]                        
Class Of Stock [Line Items]                        
Conversion of preferred stock, conversion blocker, percent           9.90%            
Jefferies LLC [Member] | ATM Program [Member]                        
Class Of Stock [Line Items]                        
Common stock number of shares issued           0 0          
Equity distribution agreement maximum value of common shares issuable         $ 75,000              
Public float minimum balance to be maintained           $ 75,000            
Jefferies LLC [Member] | ATM Program [Member] | Common Stock [Member]                        
Class Of Stock [Line Items]                        
Common stock number of shares issued         0              
Jefferies LLC [Member] | Maximum [Member] | ATM Program [Member]                        
Class Of Stock [Line Items]                        
Equity distribution agreement maximum value of common shares issuable           $ 12,300            
BVF Exchanging Stockholders [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | Series X1 Exchange Agreement [Member]                        
Class Of Stock [Line Items]                        
Conversion of stock, shares issued     9,899.99                  
BVF Exchanging Stockholders [Member] | Common Stock [Member] | Series X1 Exchange Agreement [Member]                        
Class Of Stock [Line Items]                        
Conversion of stock, shares converted     550,000                  
Cormorant Global Healthcare Master Fund LP [Member] | Series X Non-voting Convertible Preferred Stock [Member] | Conversion Agreement [Member]                        
Class Of Stock [Line Items]                        
Conversion of stock, shares converted 1,782                      
Cormorant Global Healthcare Master Fund LP [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | Conversion Agreement [Member]                        
Class Of Stock [Line Items]                        
Conversion of stock, shares converted 7,883.586                      
Cormorant Global Healthcare Master Fund LP [Member] | Common Stock [Member] | Series X Non-voting Convertible Preferred Stock [Member] | Conversion Agreement [Member]                        
Class Of Stock [Line Items]                        
Conversion of stock, shares issued 99,000                      
Cormorant Global Healthcare Master Fund LP [Member] | Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | Conversion Agreement [Member]                        
Class Of Stock [Line Items]                        
Conversion of stock, shares issued 437,977