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Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands |  | 3 Months Ended | 9 Months Ended |
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Oct. 29, 2024 | Sep. 30, 2024 | Jun. 30, 2024 | Mar. 31, 2024 | Sep. 30, 2023 | Jun. 30, 2023 | Mar. 31, 2023 | Sep. 30, 2024 | Sep. 30, 2023 | Dec. 31, 2023
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Cash, cash equivalents and restricted cash, maturity period |  |  |  |  |  |  |  | three months or less |  |
Net income (loss) |  | $ 76,971 | $ (44,907) | $ (23,631) | $ (9,906) | $ (65,760) | $ (10,772) | $ 8,433 | $ (86,438) |
Net income (losses) excluding gain of change in fair value of warrant |  | (19,500) |  |  |  |  |  | (43,400) |  |
Cash and cash equivalents and short-term investments |  | 78,200 |  |  |  |  |  | 78,200 |  |
Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds |  | 96,439 |  |  | 443 |  |  | 51,829 | (55,738) |
Working capital |  | 69,000 |  |  |  |  |  | 69,000 |  |
Accumulated deficit |  | $ (310,969) |  |  | $ (289,303) |  |  | $ (310,969) | $ (289,303) | $ (319,402)
Common stock, shares issued |  | 41,183,102 |  |  |  |  |  | 41,183,102 |  | 24,213,130
Common stock, par value |  | $ 0.001 |  |  |  |  |  | $ 0.001 |  | $ 0.001
Accounting Standards Update 2023-09 [Member] |  |  |  |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Change in accounting principle, accounting standards update, adopted |  | true |  |  |  |  |  | true |  |
Accounting Standards Update 2023-07 [Member] |  |  |  |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Change in accounting principle, accounting standards update, adopted |  | true |  |  |  |  |  | true |  |
Anelixis Therapeutics, LLC and Otic Pharma, Ltd. |  |  |  |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Ownership interest percentage |  |  |  |  |  |  |  | 100.00% |  |
Leerink Partners LLC [Member] | Subsequent event | Underwriting agreement [Member] |  |  |  |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Proceeds From Issuance Offering | $ 85,000 |  |  |  |  |  |  |  |  |
Net proceeds after deducting offering costs | $ 79,500 |  |  |  |  |  |  |  |  |
Warrants [Member] | Leerink Partners LLC [Member] | Subsequent event | Underwriting agreement [Member] |  |  |  |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Warrant exercise price | $ 3.649 |  |  |  |  |  |  |  |  |
Common Stock [Member] | Leerink Partners LLC [Member] | Subsequent event | Underwriting agreement [Member] |  |  |  |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Common stock, shares issued | 18,356,173 |  |  |  |  |  |  |  |  |
Common stock, par value | $ 0.001 |  |  |  |  |  |  |  |  |
Offering price common stock | 3.65 |  |  |  |  |  |  |  |  |
Warrant exercise price | $ 0.001 |  |  |  |  |  |  |  |  |
Common stock warrants exercisable | 4,931,507 |  |  |  |  |  |  |  |  |
Otic Pharma, Inc. [Member] |  |  |  |  |  |  |  |  |  |
Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |
Ownership interest percentage |  |  |  |  |  |  |  | 100.00% |  |

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