<SEC-DOCUMENT>0000921895-24-001131.txt : 20240513
<SEC-HEADER>0000921895-24-001131.hdr.sgml : 20240513
<ACCEPTANCE-DATETIME>20240513170415
ACCESSION NUMBER:		0000921895-24-001131
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20240509
FILED AS OF DATE:		20240513
DATE AS OF CHANGE:		20240513

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BIOTECHNOLOGY VALUE FUND L P
		CENTRAL INDEX KEY:			0000918923
		STANDARD INDUSTRIAL CLASSIFICATION:	INVESTMENT ADVICE [6282]
		ORGANIZATION NAME:           	02 Finance
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36620
		FILM NUMBER:		24940172

	BUSINESS ADDRESS:	
		STREET 1:		44 MONTGOMERY STREET
		STREET 2:		40TH FL
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104
		BUSINESS PHONE:		3125066500

	MAIL ADDRESS:	
		STREET 1:		44 MONTGOMERY STREET
		STREET 2:		40TH FL
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BVF PARTNERS L P/IL
		CENTRAL INDEX KEY:			0001055947
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36620
		FILM NUMBER:		24940173

	BUSINESS ADDRESS:	
		STREET 1:		44 MONTGOMERY ST.
		STREET 2:		40TH FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104
		BUSINESS PHONE:		3125066500

	MAIL ADDRESS:	
		STREET 1:		44 MONTGOMERY ST.
		STREET 2:		40TH FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BVF INC/IL
		CENTRAL INDEX KEY:			0001056807
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36620
		FILM NUMBER:		24940165

	BUSINESS ADDRESS:	
		STREET 1:		44 MONTGOMERY STREET
		STREET 2:		40TH FL
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104
		BUSINESS PHONE:		3125066500

	MAIL ADDRESS:	
		STREET 1:		44 MONTGOMERY STREET
		STREET 2:		40TH FL
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BIOTECHNOLOGY VALUE FUND II LP
		CENTRAL INDEX KEY:			0001102444
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36620
		FILM NUMBER:		24940170

	BUSINESS ADDRESS:	
		STREET 1:		44 MONTGOMERY STREET
		STREET 2:		40TH FL
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104
		BUSINESS PHONE:		3125066500

	MAIL ADDRESS:	
		STREET 1:		44 MONTGOMERY STREET
		STREET 2:		40TH FL
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BVF II GP LLC
		CENTRAL INDEX KEY:			0001803806
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36620
		FILM NUMBER:		24940169

	BUSINESS ADDRESS:	
		STREET 1:		44 MONTGOMERY ST., 40TH FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104
		BUSINESS PHONE:		415-525-8830

	MAIL ADDRESS:	
		STREET 1:		44 MONTGOMERY ST., 40TH FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BVF GP HOLDINGS LLC
		CENTRAL INDEX KEY:			0001803809
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36620
		FILM NUMBER:		24940166

	BUSINESS ADDRESS:	
		STREET 1:		44 MONTGOMERY ST., 40TH FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104
		BUSINESS PHONE:		415-525-8830

	MAIL ADDRESS:	
		STREET 1:		44 MONTGOMERY ST., 40TH FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Biotechnology Value Trading Fund OS LP
		CENTRAL INDEX KEY:			0001660683
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			E9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36620
		FILM NUMBER:		24940168

	BUSINESS ADDRESS:	
		STREET 1:		P.O. BOX 309 UGLAND HOUSE
		CITY:			GRAND CAYMAN
		STATE:			E9
		ZIP:			KY1-1104
		BUSINESS PHONE:		(415) 525-8890

	MAIL ADDRESS:	
		STREET 1:		P.O. BOX 309 UGLAND HOUSE
		CITY:			GRAND CAYMAN
		STATE:			E9
		ZIP:			KY1-1104

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BVF Partners OS Ltd.
		CENTRAL INDEX KEY:			0001660684
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			E9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36620
		FILM NUMBER:		24940167

	BUSINESS ADDRESS:	
		STREET 1:		P.O. BOX 309 UGLAND HOUSE
		CITY:			GRAND CAYMAN
		STATE:			E9
		ZIP:			KY1-1104
		BUSINESS PHONE:		(415) 525-8890

	MAIL ADDRESS:	
		STREET 1:		P.O. BOX 309 UGLAND HOUSE
		CITY:			GRAND CAYMAN
		STATE:			E9
		ZIP:			KY1-1104

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BVF I GP LLC
		CENTRAL INDEX KEY:			0001803805
		ORGANIZATION NAME:           	
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36620
		FILM NUMBER:		24940171

	BUSINESS ADDRESS:	
		STREET 1:		44 MONTGOMERY ST., 40TH FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104
		BUSINESS PHONE:		415-525-8830

	MAIL ADDRESS:	
		STREET 1:		44 MONTGOMERY ST., 40TH FLOOR
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			LAMPERT MARK N
		CENTRAL INDEX KEY:			0001233840
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36620
		FILM NUMBER:		24940164

	MAIL ADDRESS:	
		STREET 1:		1 SANSOME ST
		STREET 2:		30TH FL
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94104

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Eledon Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001404281
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		19800 MACARTHUR BLVD.
		STREET 2:		SUITE 250
		CITY:			IRVINE
		STATE:			CA
		ZIP:			92612
		BUSINESS PHONE:		949-238-8090

	MAIL ADDRESS:	
		STREET 1:		19800 MACARTHUR BLVD.
		STREET 2:		SUITE 250
		CITY:			IRVINE
		STATE:			CA
		ZIP:			92612

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Novus Therapeutics, Inc.
		DATE OF NAME CHANGE:	20170511

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Tokai Pharmaceuticals Inc
		DATE OF NAME CHANGE:	20070622
</SEC-HEADER>
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        <issuerName>Eledon Pharmaceuticals, Inc.</issuerName>
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            <rptOwnerName>BVF PARTNERS L P/IL</rptOwnerName>
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            <rptOwnerStreet2>40TH FL</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
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            <rptOwnerName>BIOTECHNOLOGY VALUE FUND L P</rptOwnerName>
        </reportingOwnerId>
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            <rptOwnerStreet2>40TH FL</rptOwnerStreet2>
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            <rptOwnerState>CA</rptOwnerState>
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            <otherText>See Explanation of Responses</otherText>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001803805</rptOwnerCik>
            <rptOwnerName>BVF I GP LLC</rptOwnerName>
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            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
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            <otherText>See Explanation of Responses</otherText>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001102444</rptOwnerCik>
            <rptOwnerName>BIOTECHNOLOGY VALUE FUND II LP</rptOwnerName>
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            <rptOwnerStreet2>40TH FL</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
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            <otherText>See Explanation of Responses</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001803806</rptOwnerCik>
            <rptOwnerName>BVF II GP LLC</rptOwnerName>
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        <reportingOwnerAddress>
            <rptOwnerStreet1>44 MONTGOMERY ST.</rptOwnerStreet1>
            <rptOwnerStreet2>40TH FL</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <officerTitle></officerTitle>
            <otherText>See Explanation of Responses</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001660683</rptOwnerCik>
            <rptOwnerName>Biotechnology Value Trading Fund OS LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>P.O. BOX 309 UGLAND HOUSE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>GRAND CAYMAN</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-1104</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
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            <isOfficer>0</isOfficer>
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            <otherText>See Explanation of Responses</otherText>
        </reportingOwnerRelationship>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001660684</rptOwnerCik>
            <rptOwnerName>BVF Partners OS Ltd.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>P.O. BOX 309 UGLAND HOUSE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>GRAND CAYMAN</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-1104</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
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            <otherText>See Explanation of Responses</otherText>
        </reportingOwnerRelationship>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001803809</rptOwnerCik>
            <rptOwnerName>BVF GP HOLDINGS LLC</rptOwnerName>
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            <rptOwnerStreet2>40TH FL</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
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            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
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            <rptOwnerState>CA</rptOwnerState>
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    <nonDerivativeTable>
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            <transactionDate>
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            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
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                <equitySwapInvolved>0</equitySwapInvolved>
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            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock, $0.001 par value</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>165950</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>165950</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F7"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Warrants to Purchase Common Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.00</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F14"/>
                <footnoteId id="F16"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F14"/>
                <footnoteId id="F16"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock, $0.001 par value</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>3084090</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3084090</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F5"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Warrants to Purchase Common Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.00</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F14"/>
                <footnoteId id="F16"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F14"/>
                <footnoteId id="F16"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock, $0.001 par value</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>2446209</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2446209</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F6"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Warrants to Purchase Common Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.00</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F14"/>
                <footnoteId id="F16"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F14"/>
                <footnoteId id="F16"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock, $0.001 par value</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>252291</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>252291</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F7"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">This Form 4 is filed jointly by Biotechnology Value Fund, L.P. (&quot;BVF&quot;), Biotechnology Value Fund II, L.P. (&quot;BVF2&quot;), Biotechnology Value Trading Fund OS LP (&quot;Trading Fund OS&quot;), BVF Partners OS Ltd. (&quot;Partners OS&quot;), BVF I GP LLC (&quot;BVF GP&quot;), BVF II GP LLC (&quot;BVF2 GP&quot;), BVF GP Holdings LLC (&quot;BVF GPH&quot;), BVF Partners L.P. (&quot;Partners&quot;), BVF Inc. and Mark N. Lampert (collectively, the &quot;Reporting Persons&quot;).  Each of the Reporting Persons is a member of a group for purposes of Section 13(d) of the Securities Exchange Act of 1934 (the &quot;Exchange Act&quot;) that collectively beneficially owns over 10% of the Issuer's outstanding shares of Common Stock (the &quot;Common Stock&quot;). Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein except to the extent of his or its pecuniary interest therein.</footnote>
        <footnote id="F2">Pursuant to a securities purchase agreement between the Issuer and certain institutional and accredited investors, including certain of the Reporting Persons (the &quot;2024 Purchasers&quot;), the Issuer agreed to issue and sell to the 2024 Purchasers in a private placement (the &quot;2024 Private Placement&quot;) shares of Common Stock at a price of $2.37 per share, and pre-funded warrants (the &quot;2024 Pre-Funded Warrants&quot;) at a price of $2.369 per underlying share, which are exercisable into shares of Common Stock at an exercise price of $0.001 per share.</footnote>
        <footnote id="F3">Shares of Common Stock purchased in the 2024 Private Placement.</footnote>
        <footnote id="F4">2024 Pre-Funded Warrants purchased in the 2024 Private Placement. The 2024 Pre-Funded Warrants are exercisable immediately and shall expire when exercised in full. The 2024 Pre-Funded Warrants cannot be exercised by the Reporting Persons if, after giving effect thereto, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the outstanding shares of Common Stock, subject to certain exceptions.</footnote>
        <footnote id="F5">Securities owned directly by BVF. As the general partner of BVF, BVF GP may be deemed to beneficially own the securities owned directly by BVF. As the sole member of BVF GP, BVF GPH may be deemed to beneficially own the securities owned directly by BVF. As the investment manager of BVF, Partners may be deemed to beneficially own the securities owned directly by BVF. As the general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF.</footnote>
        <footnote id="F6">Securities owned directly by BVF2. As the general partner of BVF2, BVF2 GP may be deemed to beneficially own the securities owned directly by BVF2. As the sole member of BVF2 GP, BVF GPH may be deemed to beneficially own the securities owned directly by BVF2. As the investment manager of BVF2, Partners may be deemed to beneficially own the securities owned directly by BVF2. As the general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF2. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF2.</footnote>
        <footnote id="F7">Securities owned directly by Trading Fund OS. As the general partner of Trading Fund OS, Partners OS may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment manager of Trading Fund OS and the sole member of Partners OS, Partners may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by Trading Fund OS. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by Trading Fund OS.</footnote>
        <footnote id="F8">The Series X Convertible Preferred Stock may not be exercised if, after such exercise, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d), more than 9.99% of the shares of Common Stock outstanding immediately after giving effect to such exercise. Each share of Series X Convertible Preferred Stock is convertible into 55.55 shares of Common Stock. The Series X Convertible Preferred Stock does not have an expiration date and is subject to certain adjustments pursuant to the Series X Exchange Agreement filed as Exhibit 10.1 to Form 8-K filed by the Issuer with the Securities and Exchange Commission on January 7, 2021.</footnote>
        <footnote id="F9">The Series X1 Convertible Preferred Stock may not be exercised if, after such exercise, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d), more than 9.99% of the shares of Common Stock outstanding immediately after giving effect to such exercise. Each share of Series X1 Convertible Preferred Stock is convertible into 55.55 shares of Common Stock. The Series X1 Convertible Preferred Stock does not have an expiration date and is subject to certain adjustments pursuant to the Series X1 Exchange Agreement filed as Exhibit 10.1 to Form 8-K filed by the Issuer with the Securities and Exchange Commission on January 13, 2022.</footnote>
        <footnote id="F10">Reflects a one-for-eighteen reverse stock split of the Issuer's issued and outstanding Common Stock, effective as of October 5, 2020 (the &quot;Stock Split&quot;).</footnote>
        <footnote id="F11">Pursuant to a warrant exercise agreement between the Issuer and the Reporting Persons, the Issuer issued to the Reporting Persons warrants to purchase shares of Common Stock at an exercise price of $0.72 per share, with an exercise period of five and a half years (July 14, 2025). The warrants are subject to adjustment in the event of stock splits, recapitalizations and other similar events affecting the Common Stock. The warrants cannot be exercised by the Reporting Persons if, after giving effect thereto, the Reporting Persons would beneficially own, as determined in accordance with the Exchange Act, more than 9.99% of Common Stock, subject to certain exceptions. In connection with the Stock Split, the exercise price was adjusted to $12.96.</footnote>
        <footnote id="F12">Pursuant to a purchase agreement between the Issuer and the Reporting Persons, the Issuer issued to the Reporting Persons warrants to purchase shares of the Series X1 Convertible Preferred Stock at an exercise price of $497.93 per share, with an exercise period of five years (September 14, 2025). Each warrant to purchase shares of the Series X1 Convertible Preferred Stock is convertible into 1 share of Series X1 Convertible Preferred Stock, which is convertible into 1,000 shares of Common Stock. The warrants are subject to adjustment in the event of stock splits, recapitalizations and other similar events affecting the Common Stock. The warrants cannot be exercised by the Reporting Persons if, after giving effect thereto, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of Common Stock, subject to certain exceptions. In connection with the Stock Split, the exercise price was adjusted to $8,962.74.</footnote>
        <footnote id="F13">Pursuant to a warrant exchange agreement between the Issuer and the Reporting Persons, the Issuer issued to the Reporting Persons warrants to purchase shares of Common Stock at an exercise price equal to $0.001 per share, with an exercise period of ten years (December 31, 2030). Each warrant to purchase shares of the Common Stock is convertible into 1 share of Common Stock. The warrants cannot be exercised by the Reporting Persons if, after giving effect thereto, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of Common Stock, subject to certain exceptions.</footnote>
        <footnote id="F14">Pursuant to a securities purchase agreement between the Issuer and certain institutional and accredited investors, including certain of the Reporting Persons (the &quot;2023 Purchasers&quot;), the Issuer agreed to issue and sell to the 2023 Purchasers in a private placement (the &quot;2023 Private Placement&quot;), in an initial closing, shares of the Issuer's Common Stock or pre-funded warrants in lieu thereof (the &quot;2023 Pre-Funded Warrants&quot;), and common stock warrants exercisable into shares of Common Stock (or 2023 Pre-Funded Warrants in lieu thereof) (the &quot;Common Warrants&quot;) at a per share purchase price equal to $2.31 (less $0.001 for each 2023 Pre-Funded Warrant, as applicable).</footnote>
        <footnote id="F15">2023 Pre-Funded Warrants purchased in the 2023 Private Placement. The 2023 Pre-Funded Warrants are exercisable immediately and shall expire when exercised in full. The 2023 Pre-Funded Warrants cannot be exercised by the Reporting Persons if, after giving effect thereto, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the outstanding shares of Common Stock, subject to certain exceptions.</footnote>
        <footnote id="F16">Common Warrants purchased in the 2023 Private Placement. The Common Warrants are exercisable immediately and have a term of exercise equal to five years. The Common Warrants cannot be exercised by the Reporting Persons if, after giving effect thereto, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the outstanding shares of Common Stock, subject to certain exceptions.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>BVF Partners L.P., By: BVF Inc., its general partner, By: /s/ Mark N. Lampert, President</signatureName>
        <signatureDate>2024-05-13</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Biotechnology Value Fund, L.P., By: BVF I GP LLC, its general partner, By: /s/ Mark N. Lampert, Chief Executive Officer</signatureName>
        <signatureDate>2024-05-13</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>BVF I GP LLC, By: /s/ Mark N. Lampert, Chief Executive Officer</signatureName>
        <signatureDate>2024-05-13</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Biotechnology Value Fund II, L.P., By: BVF II GP LLC, its general partner, By: /s/ Mark N. Lampert, Chief Executive Officer</signatureName>
        <signatureDate>2024-05-13</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>BVF II GP LLC, By: /s/ Mark N. Lampert, Chief Executive Officer</signatureName>
        <signatureDate>2024-05-13</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>BVF Partners OS Ltd., By: BVF Partners L.P., its sole member, By: BVF Inc., its general partner, By: /s/ Mark N. Lampert, President</signatureName>
        <signatureDate>2024-05-13</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Biotechnology Value Trading Fund OS LP, By: BVF Partners L.P., its investment manager, BVF Inc., its general partner, By: /s/ Mark N. Lampert, President</signatureName>
        <signatureDate>2024-05-13</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>BVF GP Holdings LLC, By: /s/ Mark N. Lampert, Chief Executive Officer</signatureName>
        <signatureDate>2024-05-13</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>BVF Inc., By: /s/ Mark N. Lampert, President</signatureName>
        <signatureDate>2024-05-13</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Mark N. Lampert</signatureName>
        <signatureDate>2024-05-13</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
