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Stockholders' Equity - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 12 Months Ended
Oct. 30, 2024
Oct. 29, 2024
Oct. 01, 2024
Sep. 30, 2024
Sep. 20, 2024
Jul. 08, 2024
May 06, 2024
May 16, 2023
Apr. 28, 2023
Jan. 11, 2022
Dec. 31, 2024
Dec. 31, 2023
Jul. 11, 2024
May 09, 2024
May 07, 2024
Jan. 30, 2024
Nov. 06, 2023
Nov. 02, 2023
Jul. 14, 2023
Jul. 10, 2023
Sep. 14, 2020
Class Of Stock [Line Items]                                          
Common stock, shares issued                     59,789,275 24,213,130                  
Common stock, par value                     $ 0.001 $ 0.001                  
Preferred stock, shares authorized                     5,000,000 5,000,000                  
Preferred stock, par value                     $ 0.001 $ 0.001                  
Net proceeds after deducting offering costs                     $ 133,307 $ 33,017                  
Armistice Capital Master Fund Ltd [Member] | Securities Purchase Agreement [Member]                                          
Class Of Stock [Line Items]                                          
Common stock, shares issued                         240,000 583,000   600,000 653,000   501,197    
Warrant exercise price per share                         $ 0.001   $ 0.001 $ 0.001   $ 0.001   $ 0.001  
Number of pre-funded warrants exercised for common stock                         240,000   583,000 600,000   653,000   501,197  
Series X1 Preferred Stock [Member]                                          
Class Of Stock [Line Items]                                          
Shares of common stock issued upon conversion of each share of preferred stock                     2,789,301                    
Warrants available for exercise                     50,207.419                    
Series X Non-Voting Convertible Preferred Stock [Member]                                          
Class Of Stock [Line Items]                                          
Preferred stock, shares authorized                     10,000 10,000                  
Preferred stock, par value                     $ 0.001 $ 0.001                  
Preferred stock, shares issued                     4,422 4,422                  
Preferred stock, shares outstanding                     4,422 4,422                  
Series X1 Non-voting Convertible Preferred Stock [Member]                                          
Class Of Stock [Line Items]                                          
Preferred stock, shares authorized                     515,000 515,000                  
Preferred stock, par value                     $ 0.001 $ 0.001                  
Preferred stock, shares issued                     110,086 110,086                  
Preferred stock, shares outstanding                     110,086 110,086                  
Leerink Partners LLC [Member] | Underwriting Agreement[Member]                                          
Class Of Stock [Line Items]                                          
Proceeds from issuance offering $ 85,000                                        
Net proceeds after deducting offering costs $ 79,500                                        
Common Stock [Member]                                          
Class Of Stock [Line Items]                                          
Warrants available for exercise                     33,052,744                    
Common Stock [Member] | Series X Non-Voting Convertible Preferred Stock [Member]                                          
Class Of Stock [Line Items]                                          
Shares of common stock issued upon conversion of each share of preferred stock                     55.5556                    
Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member]                                          
Class Of Stock [Line Items]                                          
Shares of common stock issued upon conversion of each share of preferred stock                     55.5556                    
Common Stock [Member] | Leerink Partners LLC [Member] | Underwriting Agreement[Member]                                          
Class Of Stock [Line Items]                                          
Conversion of stock, shares issued   18,356,173                                      
Common stock warrants exercisable   4,931,507                                      
Warrant exercise price per share   $ 0.001                                      
Stock price per share   3.65                                      
Warrants [Member] | Leerink Partners LLC [Member] | Underwriting Agreement[Member]                                          
Class Of Stock [Line Items]                                          
Warrant exercise price per share   $ 3.649                                      
Pre-Funded Warrants [Member] | Accredited Investor [Member]                                          
Class Of Stock [Line Items]                                          
Class of Warrant Subject to Specified Beneficial Ownership Limitations Percentage                 9.99%                        
Common Stock Warrants [Member]                                          
Class Of Stock [Line Items]                                          
Warrants available for exercise                     33,052,744 21,564,302                  
Common Stock Warrants [Member] | Accredited Investor [Member]                                          
Class Of Stock [Line Items]                                          
Class of Warrant Subject to Specified Beneficial Ownership Limitations Percentage                 9.99%                        
Private Placement Warrants [Member] | Accredited Investor [Member]                                          
Class Of Stock [Line Items]                                          
Warrant exercise price per share                 $ 3                        
Private Placement Warrants [Member] | Securities Purchase Agreement [Member] | Accredited Investor [Member]                                          
Class Of Stock [Line Items]                                          
Conversion of stock, shares issued             13,110,484                            
Net proceeds after deducting offering costs             $ 48,100                            
Stock price per share             $ 2.37                            
Gross proceeds             $ 50,000                            
Private Placement Warrants [Member] | Securities Purchase Agreement Initial Closing [Member]                                          
Class Of Stock [Line Items]                                          
Common warrants issued                 $ 35,000                        
Net proceeds after deducting offering costs                 $ 33,000                        
Private Placement Warrants [Member] | Securities Purchase Agreement Initial Closing [Member] | Accredited Investor [Member]                                          
Class Of Stock [Line Items]                                          
Common stock, shares issued                 15,151,518                        
Common stock, par value                 $ 0.001                        
Common stock warrants exercisable                 15,151,518                        
Private Placement Warrants [Member] | Securities Purchase Agreement Second Closing [Member]                                          
Class Of Stock [Line Items]                                          
Common stock, shares issued           909,088                              
Proceeds from issuance of common stock           $ 2,100                              
Net proceeds after deducting offering costs           $ 2,000                              
Private Placement Warrants [Member] | Securities Purchase Agreement Second Closing [Member] | Accredited Investor [Member]                                          
Class Of Stock [Line Items]                                          
Common stock, shares issued                 20,202,024                        
Private Placement Warrants [Member] | Securities Purchase Agreement Third Closing [Member]                                          
Class Of Stock [Line Items]                                          
Common stock, shares issued     1,727,400 1,727,400                                  
Proceeds from issuance of common stock     $ 4,000 $ 4,000                                  
Net proceeds after deducting offering costs     $ 3,800 $ 3,800                                  
Private Placement Warrants [Member] | Securities Purchase Agreement Third Closing [Member] | Accredited Investor [Member]                                          
Class Of Stock [Line Items]                                          
Common stock, shares issued                 25,252,530                        
Private Placement Warrants [Member] | Common Stock [Member] | Securities Purchase Agreement Initial Closing [Member]                                          
Class Of Stock [Line Items]                                          
Common stock, shares issued                 8,730,168                        
Private Placement Warrants [Member] | Pre-Funded Warrants [Member] | Accredited Investor [Member]                                          
Class Of Stock [Line Items]                                          
Warrant exercise price per share                 $ 0.001                        
Private Placement Warrants [Member] | Pre-Funded Warrants [Member] | Securities Purchase Agreement [Member] | Accredited Investor [Member]                                          
Class Of Stock [Line Items]                                          
Common stock warrants exercisable             7,989,516                            
Warrant exercise price per share             $ 0.001                            
Stock price per share             $ 2.369                            
Private Placement Warrants [Member] | Pre-Funded Warrants [Member] | Securities Purchase Agreement Initial Closing [Member]                                          
Class Of Stock [Line Items]                                          
Common stock, shares issued                 6,421,350                        
Preferred Stock Warrants [Member]                                          
Class Of Stock [Line Items]                                          
Warrant exercise price per share                                         $ 8.96
Warrants available for exercise                     50,207.419 50,207.419                  
Expiration Date                                         Sep. 14, 2025
Maximum [Member] | Common Stock [Member] | Series X Non-Voting Convertible Preferred Stock [Member]                                          
Class Of Stock [Line Items]                                          
Conversion of preferred stock, conversion blocker, percent                     9.99%                    
Maximum [Member] | Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member]                                          
Class Of Stock [Line Items]                                          
Conversion of preferred stock, conversion blocker, percent                     9.99%                    
Maximum [Member] | Pre-Funded Warrants [Member] | Accredited Investor [Member]                                          
Class Of Stock [Line Items]                                          
Class of Warrant Subject to Specified Beneficial Ownership Limitations Percentage             9.99%                            
Class of Warrant Subject to Specified Beneficial Ownership Limitations Permitted Percentage             19.99%   19.99%                        
Maximum [Member] | Pre-Funded Warrants [Member] | Leerink Partners LLC [Member] | Underwriting Agreement[Member]                                          
Class Of Stock [Line Items]                                          
Class of Warrant Subject to Specified Beneficial Ownership Limitations Percentage   9.99%                                      
Maximum [Member] | Common Stock Warrants [Member] | Accredited Investor [Member]                                          
Class Of Stock [Line Items]                                          
Class of Warrant Subject to Specified Beneficial Ownership Limitations Permitted Percentage                 19.99%                        
Minimum [Member] | Common Stock [Member] | Series X Non-Voting Convertible Preferred Stock [Member]                                          
Class Of Stock [Line Items]                                          
Conversion of preferred stock, conversion blocker, percent                     9.90%                    
Minimum [Member] | Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member]                                          
Class Of Stock [Line Items]                                          
Conversion of preferred stock, conversion blocker, percent                     9.90%                    
Minimum [Member] | Pre-Funded Warrants [Member] | Accredited Investor [Member]                                          
Class Of Stock [Line Items]                                          
Class of Warrant Subject to Specified Beneficial Ownership Limitations Percentage             4.99%                            
Minimum [Member] | Pre-Funded Warrants [Member] | Leerink Partners LLC [Member] | Underwriting Agreement[Member]                                          
Class Of Stock [Line Items]                                          
Class of Warrant Subject to Specified Beneficial Ownership Limitations Percentage   4.99%                                      
BVF Exchanging Stockholders [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | Series X1 Exchange Agreement [Member]                                          
Class Of Stock [Line Items]                                          
Conversion of stock, shares issued                   9,899.99                      
BVF Exchanging Stockholders [Member] | Common Stock [Member] | Series X1 Exchange Agreement [Member]                                          
Class Of Stock [Line Items]                                          
Conversion of stock, shares converted                   550,000                      
Cormorant Global Healthcare Master Fund LP [Member] | Series X Non-Voting Convertible Preferred Stock [Member] | Conversion Agreement [Member]                                          
Class Of Stock [Line Items]                                          
Conversion of stock, shares converted               1,782                          
Cormorant Global Healthcare Master Fund LP [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | Conversion Agreement [Member]                                          
Class Of Stock [Line Items]                                          
Conversion of stock, shares converted               7,883.586                          
Cormorant Global Healthcare Master Fund LP [Member] | Common Stock [Member] | Series X Non-Voting Convertible Preferred Stock [Member] | Conversion Agreement [Member]                                          
Class Of Stock [Line Items]                                          
Conversion of stock, shares issued               99,000                          
Cormorant Global Healthcare Master Fund LP [Member] | Common Stock [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | Conversion Agreement [Member]                                          
Class Of Stock [Line Items]                                          
Conversion of stock, shares issued               437,977                          
Guggenheim Securities LLC [Member] | Maximum [Member] | Equity Distribution Agreement [Member]                                          
Class Of Stock [Line Items]                                          
Proceeds from issuance of common stock         $ 75,000