XML 59 R46.htm IDEA: XBRL DOCUMENT v3.25.2
Commitments and Contingencies - Additional Information (Detail)
 12 Months Ended
Sep. 04, 2024
ft²
Apr. 19, 2024
USD ($)
ft²
Aug. 12, 2022
Dec. 31, 2024
USD ($)
Milestone
Dec. 31, 2023
USD ($)
Milestone
Dec. 31, 2022
USD ($)
ft²
Dec. 31, 2021
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Nov. 21, 2024
USD ($)
Other Commitments [Line Items]                    
Rental expense       $ 400,000 $ 400,000          
ROU assets       926,000 365,000          
Lease liabilities       $ 954,000            
Remaining term of office lease       3 years            
Debt outstanding       $ 0            
Indemnification obligations amount       0            
Contingent liabilities       $ 0 $ 0          
ALS Therapy Development Foundation, Inc. License Agreement [Member]                    
Other Commitments [Line Items]                    
Fee due for milestones achieved               $ 1,000,000 $ 1,000,000  
Common stock issued in lieu of making a cash payment               $ 1,000,000 $ 1,000,000  
Number of Milestones Achieved | Milestone       0 0          
Remaining milestone payments for first licensed product       $ 6,000,000            
Annual License Maintenance Fee       100,000 $ 100,000 $ 100,000 $ 100,000      
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 500 Million Aggregate Sales [Member]                    
Other Commitments [Line Items]                    
Reaching of aggregate net sales       500,000,000            
Amount of one-time milestone payment       15,000,000            
ALS Therapy Development Foundation, Inc. License Agreement [Member] | Achievement of 1 Billion Aggregate Sales [Member]                    
Other Commitments [Line Items]                    
Reaching of aggregate net sales       1,000,000,000            
Amount of one-time milestone payment       30,000,000            
eGenesis, Inc. Collaboration Agreement [Member]                    
Other Commitments [Line Items]                    
Manufacturing expenses offset       100,000            
Maximum [Member] | ALS Therapy Development Foundation, Inc. License Agreement [Member]                    
Other Commitments [Line Items]                    
Development and regulatory milestone payments       $ 2,500,000            
Irvine, California [Member]                    
Other Commitments [Line Items]                    
Operating lease, term of contract   38 months                
Area of office space | ft²   5,817       5,197        
Lease expiration date   Jun. 30, 2027 Dec. 31, 2024              
ROU assets   $ 500,000                
Burlington, Massachusetts [Member]                    
Other Commitments [Line Items]                    
Operating lease, term of contract 36 months                  
Area of office space | ft² 6,138                  
Lease expiration date Nov. 21, 2027                  
ROU assets                   $ 500,000
Lease liabilities                   $ 500,000