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Stock-Based Compensation - Summary of All Option Activity Under 2014 Plan, 2020 Plan and Inducement Grants (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Shares Issuable Under Options      
Outstanding, beginning balance 15,381,853 5,218,033  
Granted 622,000 11,026,451  
Exercised (50,000)    
Forfeited / Canceled (316,465) (862,631)  
Outstanding, ending balance 15,637,388 15,381,853 5,218,033
Options vested and expected to vest 15,637,388    
Options exercisable 8,667,177    
Weighted Average Exercise Price      
Outstanding, beginning balance $ 4.21 $ 8.69  
Granted 2.22 2.1  
Exercised 2.3    
Forfeited / Canceled 7.29 8.07  
Outstanding, ending balance 4.02 $ 4.21 $ 8.69
Options vested and expected to vest 4.02    
Options exercisable $ 5.37    
Weighted Average Remaining Contractual Term (In years)      
Outstanding, balance 7 years 6 months 8 years 10 months 24 days 8 years 1 month 6 days
Options vested and expected to vest 7 years 6 months    
Options exercisable 6 years 9 months 18 days    
Aggregate Intrinsic Value      
Aggregate intrinsic value, Outstanding $ 20,628 $ 235  
Options vested and expected to vest 20,628    
Options exercisable $ 7,898