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Summary of Significant Accounting Policies - Additional Information (Detail)
$ in Thousands
 3 Months Ended 9 Months Ended
Jul. 04, 2025
Sep. 30, 2025
USD ($)
Jun. 30, 2025
USD ($)
Mar. 31, 2025
USD ($)
Sep. 30, 2024
USD ($)
Jun. 30, 2024
USD ($)
Mar. 31, 2024
USD ($)
Sep. 30, 2025
USD ($)
Segment
Sep. 30, 2024
USD ($)
Dec. 31, 2024
USD ($)
Summary Of Significant Accounting Policies [Line Items]                    
Cash, cash equivalents and restricted cash, maturity period               three months or less    
Net loss   $ (17,459) $ (11,216) $ (6,495) $ 76,971 $ (44,907) $ (23,631) $ (35,170) $ 8,433  
Cash and cash equivalents and short-term investments   93,400           93,400    
Working capital   82,000           82,000    
Accumulated deficit   $ (390,756)           $ (390,756)   $ (355,586)
Going concern conditions or events description               The Company expects that, based on its current operating plans, the Company’s existing cash, cash equivalents and marketable securities will be sufficient to fund its currently planned operations for at least the next 12 months from the filing date of these unaudited condensed consolidated financial statements. The Company anticipates it will require additional financing to fund its future operations. Even if the Company believes it has sufficient funds for its current or future operating plans, the Company may seek to raise additional capital if market conditions are favorable or in light of other strategic considerations.    
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]               srt:ChiefExecutiveOfficerMember    
Segment Reporting, Factors Used to Identify Entity's Reportable Segments               The CODM manages and allocates resources to the operations of the Company on a total company basis. Managing and allocating resources on a consolidated basis enables the CODM to assess the overall level of resources available and how to best deploy these resources across functions, therapeutic areas and research and development projects that are in line with the Company’s long-term company-wide strategic goals.    
Number of operating segments | Segment               1    
Number of reportable segments | Segment               1    
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description               the CODM uses consolidated financial information for purposes of evaluating performance, forecasting future period financial results, allocating resources and setting incentive targets. Operating expenses are used to monitor budget versus actual results.    
Percentage of bonus depreciation and domestic research cost 100.00%                  
Anelixis Therapeutics, LLC and Otic Pharma, Ltd.                    
Summary Of Significant Accounting Policies [Line Items]                    
Ownership interest percentage               100.00%    
Otic Pharma, Inc. [Member]                    
Summary Of Significant Accounting Policies [Line Items]                    
Ownership interest percentage               100.00%