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Statements Of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Cash flows used in operating activities:      
Net loss $ (14,850) $ (14,145) $ (12,386)
Adjustments to reconcile net loss to net cash used in operating activities:      
Non-cash stock-based compensation 4,334 3,457 3,761
Depreciation and amortization 58 45 15
Non-cash net interest income (8) (4) (2)
Changes in operating assets and liabilities:      
Other current assets 86 (87) 26
Other non-current assets 12   (12)
Accounts payable (711) 841 (272)
Accrued development expense (867) 869 (616)
Accrued compensation and benefits (288) (29) (60)
Other current liabilities     (3)
Net cash used in operating activities (12,234) (9,053) (9,549)
Cash flows provided by (used in) investing activities:      
Purchases of property and equipment (75) (195) (80)
Purchases of marketable securities (4,141) (3,847) (2,598)
Maturities of marketable securities 2,050 3,850 3,850
Net cash provided by (used in) investing activities (2,166) (192) 1,172
Cash flows provided by (used in) financing activities:      
Proceeds from issuance of common stock, net     379
Statutory taxes for net exercise of Performance Awards (214)    
Deferred financing costs (70) (46)  
Net cash provided by (used in) financing activities (284) (46) 379
Net decrease in cash and cash equivalents (14,684) (9,291) (7,998)
Cash and cash equivalents at beginning of the period 31,299 40,590 48,588
Cash and cash equivalents at end of the period $ 16,615 $ 31,299 $ 40,590