<SEC-DOCUMENT>0001069530-23-000041.txt : 20230912
<SEC-HEADER>0001069530-23-000041.hdr.sgml : 20230912
<ACCEPTANCE-DATETIME>20230810163901
<PRIVATE-TO-PUBLIC>
ACCESSION NUMBER:		0001069530-23-000041
CONFORMED SUBMISSION TYPE:	CORRESP
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20230810

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CASSAVA SCIENCES INC
		CENTRAL INDEX KEY:			0001069530
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				911911336
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		CORRESP

	BUSINESS ADDRESS:	
		STREET 1:		6801 N CAPITAL OF TEXAS HIGHWAY
		STREET 2:		BUILDING 1; SUITE 300
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78731
		BUSINESS PHONE:		512-501-2444

	MAIL ADDRESS:	
		STREET 1:		6801 N CAPITAL OF TEXAS HIGHWAY
		STREET 2:		BUILDING 1; SUITE 300
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78731

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PAIN THERAPEUTICS INC
		DATE OF NAME CHANGE:	20000309
</SEC-HEADER>
<DOCUMENT>
<TYPE>CORRESP
<SEQUENCE>1
<FILENAME>filename1.htm
<TEXT>
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			Cassava - SEC Response Letter (10-k) draft
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">August </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">10</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">, 2023</font>
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			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:11pt;text-decoration:underline;">VIA EDGAR</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">Division of Corporation Finance</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">Office of Life Sciences</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">United States Securities and Exchange Commission</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">100 F Street, NE</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">Washington, D.C. 20549</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">Attention:</font><a name="_Hlk142573772"></a><font style="display: inline;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">&nbsp;&nbsp;&nbsp;&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">Ta</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">r</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">a Harkins</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">Dan Gordon</font>
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			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:11pt;">Re:</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">&nbsp;&nbsp;&nbsp;&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:11pt;">Cassava Sciences, Inc.</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:11pt;">Form 10-K for the Fiscal Year Ended December 31, 2022</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:11pt;">Filed February 28, 2023</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:11pt;">File No. 000-29959</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">Ladies and Gentlemen: </font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">Cassava Sciences, Inc. (the &#x201C;Company</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">,</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">&#x201D;</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;"> &#x201C;we&#x201D; or &#x201C;our&#x201D;</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">) &nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">is in receipt of the comment of the sta</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">ff (the &#x201C;Staff&#x201D;) of the U.S. Securities and Exchange Commission (the &#x201C;Commission&#x201D;) </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">set forth in the Commission&#x2019;s</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;"> letter dated July </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">28</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">, 2023 (the &#x201C;Comment Letter&#x201D;) with respect to the Company&#x2019;s Form 10-K for the fiscal year ended December 31, 2022 filed </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">with the Commission </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">on February 28, 2023 (the &#x201C;</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">FY 2022 </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">Form 10-K&#x201D;). </font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">For the convenience of the Staff, we have incorporated the text of the Staff&#x2019;s </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">comment</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;"> in the Comment Letter into this response letter in italicized type, </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">which is </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">followed by the Company&#x2019;s response. </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">Page </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">number </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">references are to the </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">FY2022 </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">Form 10-K. </font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;text-decoration:underline;">Components of Operating Results, page 78</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">1. </font><font style="display: inline;font-family:Times New Roman;font-style:italic;font-size:11pt;">We note the discussion on page 77 that you currently have two biopharmaceutical assets under development, simufilam and SavaDx, and that you are in stage 3 of clinical trials for some of these products. Please revise future filings to disclose the costs incurred during each period presented for each of your key research and development products/projects. If you do not track your research and development costs by project, disclose that fact and explain why you do not maintain and evaluate research and development costs by project. Provide other quantitative or qualitative disclosure that provides more transparency as to the type of research and development expenses incurred (i.e., by nature or type of expense) which should reconcile to total research and development expenses on the Consolidated Statements of Operations.</font>
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			<font style="display: inline;font-family:Times New Roman;font-weight:bold;font-size:11pt;">Response</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">: We respectfully acknowledge the Staff&#x2019;s comment</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">and </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">offer the following response.</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;"> Our </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">research and </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">development costs for SavaDx are not material to the Company </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">because these expenses</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;"> represent less than 1% of total research and developments costs for all periods presented. We will disclose </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">that SavaDx research and development expenses represent less than 1% of total research and developments costs</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;"> in future filings. We do </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">not believe</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;"> a </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">further </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">numerical disaggregation </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">between</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;"> simufilam and SavaDx </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">research and development </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">costs would be useful to a user of the financial statements </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">and would be duplicative of the &#x201C;</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">less than </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">1%&#x201D; contextual disclosure.</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;"> Thus, we do not plan to include a numerical </font>
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		<p><font size="1"> </font></p><hr size="3" style="color:#999999" width="100%" align="center"></hr><p style="page-break-after:always">&nbsp;</p>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">We will also provide additional quantitative and qualitative disclosure of our research and development expenses by nature and type of expense in future filings. This disclosure will </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">be </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">reconcile</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">d</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;"> to total research and development expenses in the Consolidated Statements of Operations.</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">If you have any questions or comments concerning this submission, please do not hesitate to contact me at </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">(51</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">2</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">)</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">&nbsp;</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">501-2450</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;"> or via email at </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">eschoen@cassavasciences.com</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">.</font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">Sincerely, </font>
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			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:justify;text-justify:inter-ideograph;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Arial;font-size: 11pt">
			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">&#xFEFF;</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:justify;text-justify:inter-ideograph;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Arial;font-size: 11pt">
			<font style="text-indent:0pt;margin-left:0pt; padding-right:121pt;"><font style="display: inline;font-family:Times New Roman;font-size:11pt;text-decoration:underline;">/s/ Eric </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;text-decoration:underline;">J. </font><font style="display: inline;font-family:Times New Roman;font-size:11pt;text-decoration:underline;">Schoen</font></font><font style="text-indent:0pt;margin-left:0pt; padding-right:4pt;text-align:left"><font style="display: inline;font-family:Times New Roman;font-size:11pt;text-decoration:underline;"></font></font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:justify;text-justify:inter-ideograph;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Arial;font-size: 11pt">
			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">Eric Schoen</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:justify;text-justify:inter-ideograph;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Arial;font-size: 11pt">
			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">Chief Fin</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">an</font><font style="display: inline;font-family:Times New Roman;font-size:11pt;">cial Officer</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:justify;text-justify:inter-ideograph;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Arial;font-size: 11pt">
			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">Cassava Sciences, Inc.</font>
		</p>
		<p style="margin:0pt;line-height:100%;text-align:justify;text-justify:inter-ideograph;border-top:1pt none #D9D9D9 ;border-bottom:1pt none #D9D9D9 ;font-family:Arial;font-size: 11pt">
			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">&#xFEFF;</font>
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		<p style="margin:0pt;line-height:100%;text-align:justify;text-justify:inter-ideograph;border-top:1pt none #D9D9D9 ;font-family:Arial;font-size: 11pt">
			<font style="display: inline;font-family:Times New Roman;font-size:11pt;">cc: Brett Cooper, Esq., Orrick, Herrington &amp; Sutcliffe LLP</font>
		</p>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
