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Note 9 - Income Taxes (Details Textual) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent | 21.00% | 21.00% | 21.00% |
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount | $ 19,400 | $ 23,300 |  |
Unrecognized Tax Benefits | 9,242 | $ 8,413 | $ 6,496 | $ 5,001
Income Tax Expense (Benefit) | 0 |  |  |
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued | $ 0 |  |  |
Open Tax Year | 2020 2021 2022 2023 2024 |  |  |
Domestic Tax Jurisdiction [Member] |  |  |  |
Operating Loss Carryforwards | $ 205,500 |  |  |
Domestic Tax Jurisdiction [Member] | Research Tax Credit Carryforward [Member] |  |  |  |
Tax Credit Carryforward, Amount | 23,000 |  |  |
Domestic Tax Jurisdiction [Member] | Carryforward Subject to Expiration [Member] |  |  |  |
Operating Loss Carryforwards | 74,100 |  |  |
Domestic Tax Jurisdiction [Member] | Indefinite Life Carryforwards [Member] |  |  |  |
Operating Loss Carryforwards | $ 131,400 |  |  |

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- Definition Percentage of domestic federal statutory tax rate applicable to pretax income (loss). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 12 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-12 Reference 2: http://www.xbrl.org/2003/role/exampleRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 55 -Paragraph 231 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482663/740-10-55-231 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 6.I.1.Q1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479360/740-10-S99-1 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Topic 235 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08(h)(2)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480678/235-10-S99-1 + Details
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