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Note 7 - Stockholders' Equity and Stock-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2024
Notes Tables |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  |  |  |  |  | Weighted Average |  |  | Weighted Average |  |  |  |  |
|  | Number of |  |  | Weighted Average |  |  | Remaining Contractual |  |  | Aggregate Intrinsic Value |
|  | Options |  |  | Exercise Price |  |  | Term in Years |  |  | in Millions |
Outstanding as of December 31, 2023 |  |  | 3,039,029 |  |  | $ | 15.13 |  |  |  | 6.21 |  |  | $ | 30.28 |
Options granted |  |  | 2,083,000 |  |  |  | 26.65 |  |  |  |  |  |  |  |  |
Options exercised |  |  | (240,147 | ) |  |  | 5.25 |  |  |  |  |  |  |  |  |
Options forfeited/canceled |  |  | (418,854 | ) |  |  | 24.64 |  |  |  |  |  |  |  |  |
Outstanding as of December 31, 2024 |  |  | 4,463,028 |  |  |  | 20.15 |  |  |  | 7.61 |  |  | $ | 0.30 |
Vested and expected to vest at December 31, 2024 |  |  | 3,965,665 |  |  |  | 19.93 |  |  |  | 7.44 |  |  | $ | 0.30 |
Exercisable at December 31, 2024 |  |  | 1,794,501 |  |  | $ | 12.86 |  |  |  | 4.95 |  |  | $ | 0.30 |
Share-Based Payment Arrangement, Option, Exercise Price Range [Table Text Block] |
|  |  |  |  |  |  |  | Options outstanding |  |  | Options exercisable |
|  |  |  |  |  |  |  |  |  |  |  | Weighted |  |  |  |  |  |  |  |  |  |  |  |  |
|  |  |  |  |  |  |  |  |  |  |  | average |  |  | Weighted |  |  |  |  |  |  | Weighted |
|  |  |  |  |  |  |  | Number of |  |  | remaining |  |  | average |  |  | Number of |  |  | average |
Range of exercise prices |  |  | outstanding |  |  | contractual |  |  | exercise |  |  | vested |  |  | exercise |
From |  |  | To |  |  | options |  |  | life (in years) |  |  | price |  |  | options |  |  | price |
$ | 0.95 |  |  | $ | 4.10 |  |  |  | 900,303 |  |  |  | 3.5 |  |  | $ | 2.80 |  |  |  | 900,303 |  |  | $ | 2.80 |
$ | 5.46 |  |  | $ | 17.54 |  |  |  | 1,049,656 |  |  |  | 7.1 |  |  | $ | 16.21 |  |  |  | 560,765 |  |  | $ | 15.06 |
$ | 18.78 |  |  | $ | 26.57 |  |  |  | 539,277 |  |  |  | 8.7 |  |  | $ | 21.90 |  |  |  | 197,198 |  |  | $ | 21.81 |
$ | 26.91 |  |  | $ | 26.91 |  |  |  | 1,080,000 |  |  |  | 9.7 |  |  | $ | 26.91 |  |  |  | 364 |  |  | $ | 26.91 |
$ | 27.42 |  |  | $ | 77.00 |  |  |  | 893,792 |  |  |  | 9.2 |  |  | $ | 33.02 |  |  |  | 135,871 |  |  | $ | 57.40 |
|  |  |  |  |  |  |  |  | 4,463,028 |  |  |  | 7.6 |  |  | $ | 20.15 |  |  |  | 1,794,501 |  |  | $ | 12.86 |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | 2024 |  |  | 2023 |  |  | 2022 |
Volatility |  |  | 151% to 170% |  |  |  | 152% to 155% |  |  |  | 151% to 154% |
Risk-free interest rates |  |  | 3.53% to 4.47% |  |  |  | 3.82% to 4.37% |  |  |  | 1.98% to 3.69% |
Expected life of option (in years) |  |  | 7 |  |  |  | 7 |  |  |  | 7 |
Dividend yield |  | zero |  |  | zero |  |  | zero |
Forfeiture rate |  | 4.3 | % |  | zero |  |  | zero |
Weighted average fair value of stock options granted |  | $ | 25.85 |  |  | $ | 18.21 |  |  | $ | 35.16 |
Share-Based Payment Arrangement, Activity [Table Text Block] |
|  | Number of Performance Awards |
Outstanding as of December 31, 2023 |  |  | 7,142 |
Granted |  |  | — |
Vested |  |  | — |
Forfeited/canceled |  |  | — |
Outstanding as of December 31, 2024 |  |  | 7,142 |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Years ended December 31, |
|  | 2024 |  |  | 2023 |  |  | 2022 |
Research and development |  | $ | 6,492 |  |  | $ | 2,050 |  |  | $ | 1,631 |
General and administrative |  |  | 9,799 |  |  |  | 2,536 |  |  |  | 435 |
Total stock-based compensation expense |  | $ | 16,291 |  |  | $ | 4,586 |  |  | $ | 2,066 |

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- Definition Tabular disclosure of activity for award under share-based payment arrangement. Includes, but is not limited to, outstanding award at beginning and end of year, granted, exercised, forfeited, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(2) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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