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Note 9 - Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2024
Notes Tables |
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] |
|  | Year ended December 31, |
|  | 2024 |  |  | 2023 |  |  | 2022 |
Tax at federal statutory rate |  |  | 21 | % |  |  | 21 | % |  |  | 21 | %
State tax, net of federal benefit |  |  | — |  |  |  | — |  |  |  | — |
Share-based compensation |  |  | (5.7 | ) |  |  | 0.2 |  |  |  | (0.5 | )
Research and development credits |  |  | 15.4 |  |  |  | 5.1 |  |  |  | 4.9 |
Section 162(m) limitation |  |  | (0.2 | ) |  |  | — |  |  |  | (0.2 | )
Uncertain tax positions |  |  | (6.1 | ) |  |  | (2.0 | ) |  |  | (2.0 | )
Tax attribute expiration |  |  | (4.1 | ) |  |  | — |  |  |  | — |
Change in fair value of warrant liabilities |  |  | 93.3 |  |  |  | — |  |  |  | — |
SEC settlement payment |  |  | (34.5 | ) |  |  | — |  |  |  | — |
Other |  |  | 0.3 |  |  |  | (0.3 | ) |  |  | 0.2 |
Change in valuation allowance |  |  | (79.4 | ) |  |  | (24.0 | ) |  |  | (23.4 | )
Effective income tax rate |  |  | — | % |  |  | — | % |  |  | — | %
Schedule of Deferred Tax Assets and Liabilities [Table Text Block] |
|  | December 31, |
|  | 2024 |  |  | 2023 |
Deferred tax assets: |  |  |  |  |  |  |  |
Net operating loss carryforwards |  | $ | 43,148 |  |  | $ | 33,322 |
Share-based compensation |  |  | 4,814 |  |  |  | 2,561 |
Research and development credit carryforwards |  |  | 13,789 |  |  |  | 12,557 |
Capitalized research and development expenses |  |  | 33,598 |  |  |  | 27,538 |
Other |  |  | 1,340 |  |  |  | 1,371 |
Total deferred tax assets |  |  | 96,689 |  |  |  | 77,349 |
Valuation allowance |  |  | (96,689 | ) |  |  | (77,349 | )
Net deferred tax assets |  |  | — |  |  |  | — |
Deferred tax liabilities: |  |  |  |  |  |  |  |
Operating lease right-of-use assets |  |  | — |  |  |  | — |
Total deferred tax liabilities |  |  | — |  |  |  | — |
Net deferred tax asset (liability) |  | $ | — |  |  | $ | — |
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] |
|  | Year ended December 31, |
|  | 2024 |  |  | 2023 |  |  | 2022 |
Beginning balance |  | $ | 8,413 |  |  | $ | 6,496 |  |  | $ | 5,001 |
Expired research and development tax credits |  | $ | (665 | ) |  | $ | (50 | ) |  | $ | — |
Additions based on tax positions related to the current year |  |  | 1,494 |  |  |  | 1,967 |  |  |  | 1,495 |
Ending balance |  | $ | 9,242 |  |  | $ | 8,413 |  |  | $ | 6,496 |

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