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Note 9 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2024

Notes Tables

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

		Year ended December 31,
		2024				2023				2022
Tax at federal statutory rate			21	%			21	%			21	%
State tax, net of federal benefit			—				—				—
Share-based compensation			(5.7	)			0.2				(0.5	)
Research and development credits			15.4				5.1				4.9
Section 162(m) limitation			(0.2	)			—				(0.2	)
Uncertain tax positions			(6.1	)			(2.0	)			(2.0	)
Tax attribute expiration			(4.1	)			—				—
Change in fair value of warrant liabilities			93.3				—				—
SEC settlement payment			(34.5	)			—				—
Other			0.3				(0.3	)			0.2
Change in valuation allowance			(79.4	)			(24.0	)			(23.4	)
Effective income tax rate			—	%			—	%			—	%

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

		December 31,
		2024				2023
Deferred tax assets:
Net operating loss carryforwards		$	43,148			$	33,322
Share-based compensation			4,814				2,561
Research and development credit carryforwards			13,789				12,557
Capitalized research and development expenses			33,598				27,538
Other			1,340				1,371
Total deferred tax assets			96,689				77,349
Valuation allowance			(96,689	)			(77,349	)
Net deferred tax assets			—				—
Deferred tax liabilities:
Operating lease right-of-use assets			—				—
Total deferred tax liabilities			—				—
Net deferred tax asset (liability)		$	—			$	—

Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]

		Year ended December 31,
		2024				2023				2022
Beginning balance		$	8,413			$	6,496			$	5,001
Expired research and development tax credits		$	(665	)		$	(50	)		$	—
Additions based on tax positions related to the current year			1,494				1,967				1,495
Ending balance		$	9,242			$	8,413			$	6,496

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- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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